Association of Albumin‐To‐Creatinine Ratio With Diabetic Retinopathy Among US Adults (NHANES 2009–2016)
Endocrinology Diabetes & Metabolism,
Год журнала:
2025,
Номер
8(1)
Опубликована: Янв. 1, 2025
This
study
investigates
the
relationship
between
albumin-to-creatinine
ratio
and
diabetic
retinopathy
(DR)
in
US
adults
using
NHANES
data
from
2009
to
2016.
assesses
predictive
efficacy
of
urinary
serum
(UACR/SACR
Ratio)
against
traditional
biomarkers
such
as
(SACR)
(UACR)
for
evaluating
DR
risk.
Additionally,
explores
potential
these
biomarkers,
both
individually
combination
with
HbA1c,
early
detection
risk
stratification
DR.
cross-sectional
analysed
2594
National
Health
Nutrition
Examination
Survey
(NHANES
2009-2016).
Multivariate
logistic
regression
models,
adjusted
demographic
(sex,
age,
race
education)
clinical
factors
(WBC,
PLT,
RDW,
HBP
CHD),
examined
associations
Biomarkers
were
continuously
quartiles
assess
dose-response
relationships.
Receiver
operating
characteristic
(ROC)
curve
analysis
evaluated
accuracy
individual
combined
models.
Elevated
SACR
levels
inversely
related
risk,
while
UACR
showed
a
positive
correlation.
The
UACR/SACR
demonstrated
superior
capability
compared
alone.
most
accurate
model
SACR,
UACR,
HbA1c
(AUC
=
0.614),
highlighting
development
complexity.
Subgroup
analyses
revealed
stronger
participants
aged
<
60
years
those
hypertension
(both
p
0.05),
more
pronounced
effects
observed
males
Mexican
Americans,
lifestyle
no
significant
modifying
effect.
Ratio
emerged
potentially
predictor,
particularly
younger
patients
hypertension,
suggesting
its
utility
enhancing
stratification.
Comprehensive
evaluation
renal
function
glycaemic
control
considering
age-
comorbidity-specific
patterns,
could
improve
prediction
management.
Future
longitudinal
studies
should
validate
findings,
identified
high-risk
subgroups,
investigate
underlying
mechanisms,
advancing
personalised
management
strategies.
Язык: Английский
Causal Impacts of Psychiatric Disorders on Cognition and the Mediating Effect of Oxidative Stress: A Mendelian Randomization Study
Antioxidants,
Год журнала:
2025,
Номер
14(2), С. 162 - 162
Опубликована: Янв. 29, 2025
Many
psychiatric
disorders
are
associated
with
major
cognitive
deficits.
However,
it
is
uncertain
whether
these
deficits
develop
as
a
result
of
and
what
shared
risk
factors
might
mediate
this
relationship.
Here,
we
utilized
the
Mendelian
randomization
(MR)
analysis
to
investigate
complex
causal
relationship
between
nine
three
phenotypes,
while
also
examining
potential
mediating
role
oxidative
stress
biological
underpinning.
Schizophrenia
(SZ),
depressive
disorder
(MDD),
attention
deficit
hyperactivity
(ADHD)
showed
decreasing
effect
on
performance,
intelligence,
education,
bipolar
(BPD)
increased
educational
attainment.
MR-Clust
results
exhibit
genetic
basis
SZ
other
in
relation
function.
Furthermore,
when
was
considered
factor,
associations
dimensions
cognition,
well
MDD
intelligence
ADHD
exhibited
larger
sizes
than
overall.
Mediation
MR
supported
effects
cognition
via
traits,
including
carotene,
vitamin
E,
bilirubin,
uric
acid.
Finally,
summary-based
identified
29
genes
both
performance
disorders.
Our
findings
highlight
importance
considering
understanding
potentially
treating
impairments
conditions.
Язык: Английский