Antioxidant and Anti-Inflammatory Effects of Bioactive Compounds in Atherosclerosis

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1379 - 1379

Опубликована: Фев. 6, 2025

Atherosclerosis, a chronic inflammatory disease characterized by the accumulation of lipids and immune cells within arterial walls, remains leading cause cardiovascular morbidity mortality worldwide. Oxidative stress inflammation are central to its pathogenesis, driving endothelial dysfunction, foam cell formation, plaque instability. Emerging evidence highlights potential bioactive compounds with antioxidant anti-inflammatory properties mitigate these processes promote vascular health. This review explores mechanisms through which compounds-such as polyphenols, carotenoids, flavonoids, omega-3 fatty acids, coenzyme Q10, other natural compounds-modulate oxidative in atherosclerosis. It examines their effects on key molecular pathways, including inhibition reactive oxygen species (ROS) production, suppression nuclear factor-κB (NF-κB), modulation cytokines. By integrating current knowledge, this underscores therapeutic dietary supplemental complementary strategies for managing atherosclerosis, paving way future research clinical applications.

Язык: Английский

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Protective Effects of Flavonoids-rich and Saponins-rich Extracts from Tiger Nuts and Date Fruits on Prostate Histoarchitechture in Aluminum-exposed Wistar Rats

Journal of Complementary and Alternative Medical Research, Год журнала: 2025, Номер 26(1), С. 1 - 11

Опубликована: Янв. 3, 2025

Aim: To evaluate the histological effects of flavonoid and saponin fractions from Cyperus esculentus (tiger nuts) Phoenix dactylifera (date fruits) on prostate gland Wistar rats exposed to aluminum chloride, focusing their potential protective properties against aluminum-induced toxicity. Study Design: A randomized experimental study involving twenty-five male divided into five groups. Groups were treated with normal saline (control), different combinations extracts for 28 days. Place Duration: Conducted at animal breeding facility College Medical Sciences, University Calabar, over a month. Methods: Male acclimatized seven days, then assigned treatment Flavonoids saponins extracted dactylifera. The groups received oral administration chloride once daily Prostate tissues collected post-treatment processed hematoxylin eosin (H&E) evaluation. Results: Histological analysis showed that control group had healthy architecture, while chloride-treated presented significant dysplastic changes typical benign prostatic hyperplasia (BPH). Treatment resulted in moderate improvements. combination both exhibited enhanced effects, stabilizing architecture preventing severe stromal hyperplasia. Conclusion: Flavonoid demonstrate chloride-induced histopathological rats, suggesting dietary interventions mitigate environmental toxin impacts health. Further investigation mechanisms broader applications is warranted.

Язык: Английский

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Sustainable biosynthesis of silver nanoparticles from Gmelina arborea: Photocatalytic, in vitro biological implications, and in silico analysis for microbial metalloproteins

Journal of Molecular Liquids, Год журнала: 2025, Номер 422, С. 126966 - 126966

Опубликована: Янв. 21, 2025

Язык: Английский

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Unveiling the nutritional and bioactive potential of bamboo (Bambusa tulda Roxb.) tea: A phytochemical and spectroscopic study

Advances in Bamboo Science, Год журнала: 2025, Номер unknown, С. 100132 - 100132

Опубликована: Фев. 1, 2025

Язык: Английский

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MCnebula analysis combined with alpha-glucosidase inhibitory screening reveals potential chemical contributors to efficacy enhancement of natural products after processing

Food Research International, Год журнала: 2025, Номер 205, С. 115985 - 115985

Опубликована: Фев. 11, 2025

Язык: Английский

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Recovery of high-value components from Bauhinia variegata leaves using ultrasound-microwave-assisted extraction technique

Biomass and Bioenergy, Год журнала: 2025, Номер 195, С. 107709 - 107709

Опубликована: Фев. 13, 2025

Язык: Английский

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Phytochemical Insights into Flavonoids in Cancer: Mechanisms, Therapeutic Potential, and the Case of Quercetin

Heliyon, Год журнала: 2025, Номер 11(4), С. e42682 - e42682

Опубликована: Фев. 1, 2025

Язык: Английский

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Screening of aqueous plant extracts for immunomodulatory effects on immune cells and cytokine production: in vitro and in vivo analyses

Heliyon, Год журнала: 2025, Номер 11(4), С. e42692 - e42692

Опубликована: Фев. 1, 2025

This study investigates the immunomodulatory effects of various aqueous plant extracts on immune cells and cytokine production. In vitro, several extracts, including holy basil (Ocimum sanctum), patawali (Tinospora crispa), Indian borage (Plectranthus amboinicus L.), significantly increased CD3+ T-cell populations, while soap pod (Acacia concinna), garlic (Allium sativum neem (Azadirachta indica) also boosted CD45RA+ B-cells. vivo, had subtle spleen morphology Peyer's Patches, with milk bush (Euphorbia tirucalli L.) enhancing responses, stimulated Additionally, we observed that Neem suppressed B-cell populations. Furthermore, analysis showed reduced IL-2, pod, basil, TNF-alpha levels. Soap elevated IL-10 IL-17A, indicating both anti-inflammatory pro-inflammatory signaling, induced an increase in IL-4. conclusion, Thai medicinal plants show strong potential as immunostimulants immunosuppressants. They can enhance lymphocyte proliferation, particularly T-cells, modulate Their play a key role regulating Th1, Th2, Th17 Thus, these could serve natural agents alternative medicines for boosting or modulating function.

Язык: Английский

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A Comprehensive Review of the Chemical Constituents and Functional Properties of Adzuki Beans (Vigna angulariz)

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

The adzuki bean (Vigna angulariz), a member of the Vigna genus within Leguminosae family, is native to China and extensively cultivated across East Asia. Renowned for its rich nutritional profile, abundant in carbohydrates, proteins, bioactive compounds such as polysaccharides, polyphenols, flavonoids, saponins, peptides. These components confer wide range health-promoting properties, including potent antioxidant, anti-inflammatory, antidiabetic, antiobesity, antibacterial, neuroprotective effects. Notably, beans exhibit unique functional high resistant starch content ability modulate gut microbiota by promoting beneficial bacteria like Akkermansia, which enhance insulin sensitivity lipid metabolism. attributes make particularly effective managing chronic diseases diabetes, obesity, cardiovascular disorders. Additionally, show promise addressing conditions muscle atrophy, osteoporosis, cancer. Processing methods fermentation heat treatment further their potential, underscoring suitability developing foods nutraceuticals. This review highlights chemical composition, activities, mechanisms beans, providing valuable insights application food pharmaceutical industries prevent manage diseases.

Язык: Английский

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Sodium-glucose co-transporter inhibitors for APOL1 kidney disease: A call for studies

International Urology and Nephrology, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Язык: Английский

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