Emerging role of spasmolytic polypeptide-expressing metaplasia in gastric cancer DOI Open Access
Qiange Ye, Yanmei Zhu, Yuxiang Ma

и другие.

Journal of Gastrointestinal Oncology, Год журнала: 2024, Номер 15(6), С. 2673 - 2683

Опубликована: Дек. 1, 2024

Gastric cancer (GC) ranks among the top five most diagnosed cancers globally, with particularly high incidence and mortality rates observed in Asian regions. Despite certain advancements achieved through early screening treatment strategies many countries, GC continues to pose a significant public health challenge. Approximately 20% of patients infected Helicobacter pylori develop precancerous lesions, which metaplasia is critical. Except for intestinal (IM), characterized by goblet cells appearing stomach glands, one type mucous cell metaplasia, spasmolytic polypeptide-expressing (SPEM), has attracted much attention. SPEM represents specific epithelial alteration within gastric mucosa, expressing trefoil factor 2 (TFF2) basal resembling deep antral gland cells. It primarily arises from transdifferentiation mature chief cells, neck (MNCs), or isthmus stem commonly regarded as precursor lesion development inflammation subsequent carcinogenesis. The formation intricately associated chronic inflammation, infection, various other environmental genetic factors. Recently, profound exploration biological molecular mechanisms underlying SPEM, deeper understanding its role initiation progression emerged. This review summarizes role, mechanisms, clinical significance onset GC.

Язык: Английский

Crosstalk Between Antioxidants and Adipogenesis: Mechanistic Pathways and Their Roles in Metabolic Health DOI Creative Commons
M.W. Fu,

Kyung‐Sik Yoon,

Joohun Ha

и другие.

Antioxidants, Год журнала: 2025, Номер 14(2), С. 203 - 203

Опубликована: Фев. 10, 2025

The interplay between oxidative stress and adipogenesis is a critical factor in the development of obesity its associated metabolic disorders. Excessive reactive oxygen species (ROS) disrupt key transcription factors such as peroxisome proliferator-activated receptor gamma (PPARγ) CCAAT/enhancer-binding protein alpha (C/EBPα), impairing lipid metabolism, promoting adipocyte dysfunction, exacerbating inflammation insulin resistance. Antioxidants, classified endogenous (e.g., glutathione, superoxide dismutase, catalase) exogenous polyphenols, flavonoids, vitamins C E), are pivotal mitigating these effects by restoring redox balance preserving functionality. Endogenous antioxidants neutralize ROS safeguard cellular structures; however, under heightened stress, defenses often insufficient, necessitating dietary supplementation. Exogenous derived from plant-based sources, polyphenols vitamins, act through direct scavenging, upregulation antioxidant enzymes, modulation signaling pathways like nuclear kappa B (NF-κB) PPARγ, reducing peroxidation, inflammation, dysfunction. Furthermore, they influence epigenetic regulation transcriptional networks to restore differentiation limit accumulation. Antioxidant-rich diets, including Mediterranean diet, strongly with improved health, reduced rates, enhanced sensitivity. Advances personalized therapies, guided biomarkers supported novel delivery systems, present promising avenues for optimizing therapeutic interventions. This review, "Crosstalk Between Antioxidants Adipogenesis: Mechanistic Pathways Their Role Metabolic Health", highlights mechanistic which regulate enhance health.

Язык: Английский

Процитировано

1
Inhibition of Thioredoxin-Reductase by Auranofin as a Pro-Oxidant Anticancer Strategy for Glioblastoma: In Vitro and In Vivo Studies DOI Open Access
Nelly S. Chmelyuk,

Maria Kordyukova,

Maria Sorokina

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2084 - 2084

Опубликована: Фев. 27, 2025

Reactive oxygen species (ROS) play a key role in cancer progression and antitumor therapy. Glioblastoma is highly heterogeneous tumor with different cell populations exhibiting various redox statuses. Elevated ROS levels cells promote growth simultaneously make them more sensitive to anticancer drugs, but further elevation leads death apoptosis. Meanwhile, subsets of cells, such glioblastoma stem (GSC) or the microenvironment (TME), demonstrate adaptive mechanisms excessive production by developing effective antioxidant systems as glutathione- thioredoxin-dependent. GSCs higher chemoresistance lower than other glioma while TME create pro-oxidative environment have immunosuppressive effects. Both subpopulations become an attractive target for therapies. Increased expression thioredoxin reductase (TrxR) often associated poor patient survival. Various TrxR inhibitors been investigated potential therapies, including nitrosoureas, flavonoids metallic complexes. Gold derivatives are irreversible TrxR. Among them, auranofin (AF), selective inhibitor, has proven its effectiveness drug treatment rheumatoid arthritis efficacy agent demonstrated preclinical studies vitro vivo. However, clinical application AF could be challenging due low solubility insufficient delivery glioblastoma. Different strategies hydrophobic drugs used increase concentration brain. Combining therapeutic approaches that affect status new strategy treating brain diseases.

Язык: Английский

Процитировано

0
Disrupting reconsolidation by systemic inhibition of Thioredoxin-1 attenuates cocaine and morphine relapse DOI
Hao Wu, Z. Song, Qijun Chen

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 186, С. 118037 - 118037

Опубликована: Апрель 8, 2025

Язык: Английский

Процитировано

0
Molecular identification of a thioredoxin peroxidase in Babesia gibsoni with potential against oxidative stress DOI Creative Commons
Jiaying Guo, Fangjie Li,

Lingna Wang

и другие.

Parasitology Research, Год журнала: 2025, Номер 124(3)

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Probiotic and fermentation properties of Leuconostoc mesenteroides strain I1/53 from sugarcane juice by a multi-omics approach DOI Creative Commons
Huihui Su, Yishan Guo, Hao Cheng

и другие.

LWT, Год журнала: 2024, Номер 211, С. 116897 - 116897

Опубликована: Окт. 19, 2024

Язык: Английский

Процитировано

3
Paraptosis—A Distinct Pathway to Cell Death DOI Open Access

C Kunst,

Deniz Tümen,

Martha Ernst

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(21), С. 11478 - 11478

Опубликована: Окт. 25, 2024

Cell death is a critical biological process necessary for development, tissue maintenance, and defense against diseases. To date, more than 20 forms of cell have been identified, each defined by unique molecular pathways. Understanding these different essential investigating the pathogenesis diseases such as cancer, neurodegenerative disorders, autoimmune conditions developing appropriate therapies. Paraptosis distinct form regulated characterized cytoplasmic vacuolation dilatation cellular organelles like mitochondria endoplasmic reticulum (ER). It several signaling pathways, instance, those associated with ER stress, calcium overload, oxidative specific cascades insulin-like growth factor I receptor (IGF-IR) its downstream pathways comprising mitogen-activated protein kinases (MAPKs) Jun N-terminal kinase (JNK). has observed in diverse contexts, including development stress responses neuronal, retinal, endothelial, muscle cells. The induction paraptosis increasingly important anticancer therapy, it targets non-apoptotic tumor cells, which can be utilized to induce death. This approach enhances treatment efficacy addresses drug resistance, particularly cases where cancer cells are resistant apoptosis. Combining paraptosis-inducing agents traditional therapies holds promise enhancing overcoming suggesting valuable strategy therapy.

Язык: Английский

Процитировано

1
Emerging role of spasmolytic polypeptide-expressing metaplasia in gastric cancer DOI Open Access
Qiange Ye, Yanmei Zhu, Yuxiang Ma

и другие.

Journal of Gastrointestinal Oncology, Год журнала: 2024, Номер 15(6), С. 2673 - 2683

Опубликована: Дек. 1, 2024

Gastric cancer (GC) ranks among the top five most diagnosed cancers globally, with particularly high incidence and mortality rates observed in Asian regions. Despite certain advancements achieved through early screening treatment strategies many countries, GC continues to pose a significant public health challenge. Approximately 20% of patients infected Helicobacter pylori develop precancerous lesions, which metaplasia is critical. Except for intestinal (IM), characterized by goblet cells appearing stomach glands, one type mucous cell metaplasia, spasmolytic polypeptide-expressing (SPEM), has attracted much attention. SPEM represents specific epithelial alteration within gastric mucosa, expressing trefoil factor 2 (TFF2) basal resembling deep antral gland cells. It primarily arises from transdifferentiation mature chief cells, neck (MNCs), or isthmus stem commonly regarded as precursor lesion development inflammation subsequent carcinogenesis. The formation intricately associated chronic inflammation, infection, various other environmental genetic factors. Recently, profound exploration biological molecular mechanisms underlying SPEM, deeper understanding its role initiation progression emerged. This review summarizes role, mechanisms, clinical significance onset GC.

Язык: Английский

Процитировано

0