BMC Cardiovascular Disorders, Год журнала: 2025, Номер 25(1)
Опубликована: Апрель 10, 2025
We evaluated the effects of trimetazidine (TMZ) on oxidative-antioxidative balance and angiogenesis in an vivo experimental model. This study aims to evaluate through histological analysis assess its impact biochemical measurements. In this study, Ross 308 breed chicken eggs (n = 40) were used, embryos divided into four distinct groups. On eighth day incubation, vascular density was examined. Following assessment development, 4-5 mL albumin collected via syringe measure oxidative stress markers. Each group consisted 10 embryos, with a total 40 used study. The groups organized as follows: Control Group (CG), Bevacizumab (BC), Trimetazidine 10⁻⁴ Group, 10⁻⁵ Group. When capacity (TOC) levels compared among groups, bevacizumab exhibited significantly higher values than control (p < 0.05). index (OSI) measurements, also showed contrast, when antioxidant (TAC) compared, both demonstrated Regarding scoring, significant anti-angiogenic effect group. However, no statistically difference observed between > activity Chorioallantoic Membrane (CAM) model at M concentrations. positive or negative detected. believe that real-time observation our provided value research.
Язык: Английский