Neuroprotective Effects of Myrtle Berry By-Product Extracts on 6-OHDA-Induced Cytotoxicity in PC12 Cells
Antioxidants,
Год журнала:
2025,
Номер
14(1), С. 88 - 88
Опубликована: Янв. 13, 2025
The
rising
global
focus
on
healthy
lifestyles
and
environmental
sustainability
has
prompted
interest
in
repurposing
plant-based
by-products
for
health
benefits.
With
increasing
life
expectancy,
the
incidence
of
neurodegenerative
diseases—characterized
by
complex,
multifactorial
mechanisms
such
as
abnormal
protein
aggregation,
mitochondrial
dysfunction,
oxidative
stress,
inflammation—continues
to
grow.
Medicinal
plants,
with
their
diverse
bioactive
compounds,
offer
promising
therapeutic
avenues
conditions.
Myrtus
communis
L.,
a
Mediterranean
plant
primarily
used
liquor
production,
generates
significant
waste
rich
antioxidant
anti-inflammatory
properties.
This
study
explores
neuroprotective
potential
berry
cellular
model
neurodegeneration.
Using
PC12
cells
exposed
6-hydroxydopamine
(6-OHDA),
we
assessed
cell
viability
via
MTT
assay
measured
reactive
oxygen
species
(ROS)
production
using
DCFDA
fluorescence.
Additionally,
analyzed
expression
genes
linked
stress
neuronal
function,
including
AChE,
PON2,
Grin1,
Gabrd,
c-fos,
RT-PCR.
Our
findings
reveal
that
extract
significantly
protects
against
6-OHDA-induced
cytotoxicity,
reduces
ROS
levels,
modulates
key
stress-related
genes,
underscoring
its
agent.
These
results
highlight
promise
extracts
mitigating
processes,
paving
way
future
interventions.
Язык: Английский
Altered serum glutathione disulfide levels in acute relapsed schizophrenia are associated with clinical symptoms and response to electroconvulsive therapy
BMC Psychiatry,
Год журнала:
2025,
Номер
25(1)
Опубликована: Март 14, 2025
The
pathophysiological
mechanisms
of
schizophrenia
are
complex
and
not
fully
elucidated.
This
study
aimed
to
investigate
changes
total
glutathione
(T-GSH),
disulfide
(GSSG),
reduced
(GSH),
the
GSH/GSSG
ratio
before
after
electroconvulsive
therapy
(ECT)
for
patients
with
acute
relapse
associations
clinical
symptoms.
cohort
included
110
55
healthy
controls.
All
received
8–10
sessions
ECT.
Clinical
symptoms
were
assessed
using
Positive
Negative
Syndrome
Scale
(PANSS).
As
compared
controls,
had
decreased
baseline
GSSG
levels
(t
=
-2.115,
p
0.036)
elevated
ratios
2.141,
0.034).
Baseline
negatively
correlated
both
PANSS
scores
(beta
-0.369,
t
-4.108,
<
0.001)
positive
symptom
-0.332,
-3.730,
0.001),
while
positively
improvements
in
(r
0.392,
0.293,
0.005)
ECT
treatment.
In
treatment
responders,
significantly
increased
-2.817,
0.006)
4.474,
as
ECT,
T-GSH
(B
0.734,
OR
2.083,
95%CI:1.287–3.372,
0.003),
-2.720,
0.066,
95%CI:0.011–0.390,
-1.013,
0.363,
95%CI:0.142–0.930,
0.035)
predictive
improvement.
Patients
exhibit
significant
redox
imbalance,
may
serve
a
potential
biomarker
evaluate
predict
outcomes.
Язык: Английский
Cerebral Small Vessel Disease: Therapeutic Approaches Targeting Neuroinflammation, Oxidative Stress, and Endothelial Dysfunction
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(4), С. 232 - 232
Опубликована: Март 27, 2025
Cerebral
small
vessel
disease
(cSVD)
is
a
common
cause
of
stroke
and
dementia.
Ageing,
hypertension,
hyperglycaemia,
smoking
make
up
the
biggest
risk
factors
for
cSVD.
They
individually
or
collectively
increase
levels
reactive
oxygen
species,
pro-inflammatory
cytokines
matrix
metalloproteinases,
decrease
bioavailability
nitric
oxide,
and,
in
process,
compromise
structural
integrity
function
vascular
endothelium,
blood–brain
barrier,
brain
parenchyma.
These
then
appear
as
white
matter
hyperintensities,
enlarged
perivascular
spaces,
cerebral
microbleeds,
atrophy
imaging.
As
there
currently
no
curative
therapy
cSVD,
prevention
delay
cSVD
remains
particular
importance
to
preserve
quality
life
long
possible.
Bearing
that
mind,
this
review
explores
whether
drugs
used
other
neurovascular
conditions
may
prevent
neuroinflammation
oxidative
damage
effectively
maintain
endothelial
barrier
integrity.
It
also
examines
potential
benefits
be
extended
The
list
includes
anti-anginal
drugs,
acetylcholine
esterase
inhibitors,
β-hydroxy
β-methylglutaryl-CoA
reductase
lithium
phosphodiesterase
oral
antihyperglycaemic
tetracycline
antibiotics.
This
discusses
mechanisms
action
these
agents
critically
evaluates
preclinical,
translational,
clinical
research
pertaining
Язык: Английский
Lion’s Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential—A Narrative Review
Nutrients,
Год журнала:
2025,
Номер
17(8), С. 1307 - 1307
Опубликована: Апрель 9, 2025
Hericium
erinaceus,
commonly
known
as
lion’s
mane
mushroom,
has
gained
increasing
scientific
interest
due
to
its
rich
composition
of
bioactive
compounds
and
diverse
health-promoting
properties.
This
narrative
review
provides
a
comprehensive
overview
the
nutritional
therapeutic
potential
H.
with
particular
focus
on
anti-inflammatory,
antioxidant,
antimicrobial
activities.
A
structured
literature
search
was
performed
using
databases
such
PubMed,
Scopus,
Science
Direct,
Web
Science,
Google
Scholar.
Studies
published
in
last
two
decades
focusing
erinaceus’
were
included.
The
chemical
erinaceus
includes
polysaccharides,
terpenoids
(hericenones
erinacines),
phenolic
compounds,
which
exhibit
potent
antioxidant
effects
by
scavenging
reactive
oxygen
species
(ROS)
inducing
endogenous
enzymes.
Additionally,
shows
promising
activity
against
bacterial
fungal
pathogens,
applications
combating
antibiotic-resistant
infections.
mushroom’s
capacity
stimulate
nerve
growth
factor
(NGF)
synthesis
highlighted
preventing
managing
neurodegenerative
diseases,
Alzheimer’s
Parkinson’s.
Advances
biotechnological
methods,
including
optimized
cultivation
techniques
novel
extraction
may
further
enhance
bioavailability
pharmacological
erinaceus.
Despite
findings,
clinical
validation
remains
limited.
Future
research
should
prioritize
large-scale
trials,
standardization
elucidation
pharmacokinetics
facilitate
integration
into
evidence-based
medicine.
functional
food,
nutraceutical,
adjunct
agent
highlights
need
for
interdisciplinary
collaboration
between
researchers,
clinicians,
regulatory
bodies.
Язык: Английский
Roles of Oxidative Stress and Autophagy in Alcohol-Mediated Brain Damage
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 302 - 302
Опубликована: Фев. 28, 2025
Excessive
alcohol
consumption
significantly
impacts
human
health,
particularly
the
brain,
due
to
its
susceptibility
oxidative
stress,
which
contributes
neurodegenerative
conditions.
Alcohol
metabolism
in
brain
occurs
primarily
via
catalase,
followed
by
CYP2E1
pathways.
Excess
metabolized
generates
reactive
oxygen/nitrogen
species
(ROS/RNS),
leading
cell
injury
altering
many
different
Elevated
stress
impairs
autophagic
processes,
increasing
post-translational
modifications
and
further
exacerbating
mitochondrial
dysfunction
ER
death.
The
literature
highlights
that
alcohol-induced
disrupts
autophagy
mitophagy,
contributing
neuronal
damage.
Key
mechanisms
include
dysfunction,
epigenetics,
accumulation
of
oxidatively
modified
proteins,
lead
neuroinflammation
impaired
cellular
quality
control.
These
processes
are
exacerbated
chronic
exposure,
resulting
suppression
protective
pathways
like
NRF2-mediated
antioxidant
responses
increased
changes
brain.
Alcohol-mediated
neurotoxicity
involves
complex
interactions
between
metabolism,
regulation,
influenced
various
factors
such
as
drinking
patterns,
nutritional
status,
genetic/environmental
factors,
highlighting
need
for
molecular
studies
unravel
these
develop
targeted
interventions.
Язык: Английский
Aging, vascular dysfunction, and the blood–brain barrier: unveiling the pathophysiology of stroke in older adults
Biogerontology,
Год журнала:
2025,
Номер
26(2)
Опубликована: Март 5, 2025
Язык: Английский
Antioxidant Mechanisms of the Protective Action of Selenase in Experimental Chronic Generalized Periodontitis
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(3), С. 186 - 186
Опубликована: Март 12, 2025
Inflammatory
periodontal
diseases,
despite
all
the
efforts
of
modern
dentistry,
remain
an
important
predictor
tooth
loss
worldwide.
Oxidative
stress
plays
a
crucial
role
in
pathogenesis
periodontitis,
making
use
antioxidants
attractive
option
for
its
treatment.
Our
attention
was
drawn
to
selenium
compound
Selenase
as
antioxidant
therapeutic
agent.
In
this
study,
we
modeled
calcium-deficient
prooxidant
chronic
generalized
periodontitis
(CGP)
model
white
non-linear
rats.
Then,
after
14
days,
(50
μg/kg)
and
Mexidol
(250
mg/kg)
were
administered
intragastrically.
Blood
samples
from
animals
analyzed
using
ELISA
biochemical
methods
determine
Cu-Zn
SOD,
nitrotyrosine,
GPX-4,
iNOS,
NOx,
GSH,
GSSG
levels.
The
CGP
led
typical
clinical
signs
including
hyperemia,
edema,
gingival
pocket
formation,
bleeding,
mobility,
well
increase
molecular–biochemical
markers
nitrosative
reduction
endogenous
blood.
resulted
decrease
manifestations
CGP,
reduced
NOx
levels,
SOD
GPX-4
compared
control
group
(p
<
0.05).
had
less
pronounced
effect
on
these
Язык: Английский
Nicotinamide derivatives protect the blood-brain barrier against oxidative stress
Biomedicine & Pharmacotherapy,
Год журнала:
2025,
Номер
186, С. 118018 - 118018
Опубликована: Апрель 3, 2025
Язык: Английский
Investigative assessment of the neuro-modulatory potentials of cannabichromene in TrkB/BDNF-mediated neurosignaling pathway
Comparative Clinical Pathology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 5, 2025
Язык: Английский
Role of Antioxidants in Modulating the Microbiota–Gut–Brain Axis and Their Impact on Neurodegenerative Diseases
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(8), С. 3658 - 3658
Опубликована: Апрель 12, 2025
This
narrative
review
presents
the
role
of
antioxidants
in
regulating
gut
microbiota
and
impact
on
gut–brain
axis,
with
a
particular
focus
neurodegenerative
diseases,
such
as
Alzheimer’s
(AD)
Parkinson’s
disease
(PD).
These
diseases
are
characterised
by
cognitive
decline,
motor
dysfunction,
neuroinflammation,
all
which
significantly
exacerbated
oxidative
stress.
elucidates
contribution
damage
to
progression
explores
potential
mitigate
these
pathological
processes
through
modulation
associated
pathways.
Based
recent
studies
retrieved
from
reputable
databases,
including
PubMed,
Web
Science,
Scopus,
this
article
outlines
mechanisms
influence
health
exert
neuroprotective
effects.
Specifically,
it
discusses
how
antioxidants,
polyphenols,
vitamins,
flavonoids,
contribute
reduction
reactive
oxygen
species
(ROS)
production
thereby
promoting
neuronal
survival
minimising
brain.
In
addition,
modulating
key
molecular
pathways
involved
stress
NF-κB,
Nrf2,
MAPK,
PI3K/AKT
pathways,
regulate
ROS
generation,
inflammatory
cytokine
expression,
antioxidant
responses
essential
for
maintaining
cellular
homeostasis
both
central
nervous
system.
complex
relationship
between
gut-derived
metabolites,
stress,
highlighting
dysbiosis—an
imbalance
microbiota—can
exacerbate
accelerating
AD
PD.
The
also
examines
short-chain
fatty
acids
(SCFAs)
produced
beneficial
bacteria
attenuate
neuroinflammation
damage.
Furthermore,
therapeutic
microbiota-targeted
interventions,
delivery
probiotics
prebiotics,
innovative
strategies
restore
microbial
support
brain
health.
By
synthesising
current
knowledge
interplay
underlying
neurodegeneration,
highlights
promise
antioxidant-based
interventions
mitigating
progression.
It
need
further
research
into
antioxidant-rich
dietary
microbiota-focused
therapies
promising
avenues
prevention
treatment
diseases.
Язык: Английский