Antioxidant and Anti-Inflammatory Effects of Bioactive Compounds in Atherosclerosis

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1379 - 1379

Опубликована: Фев. 6, 2025

Atherosclerosis, a chronic inflammatory disease characterized by the accumulation of lipids and immune cells within arterial walls, remains leading cause cardiovascular morbidity mortality worldwide. Oxidative stress inflammation are central to its pathogenesis, driving endothelial dysfunction, foam cell formation, plaque instability. Emerging evidence highlights potential bioactive compounds with antioxidant anti-inflammatory properties mitigate these processes promote vascular health. This review explores mechanisms through which compounds-such as polyphenols, carotenoids, flavonoids, omega-3 fatty acids, coenzyme Q10, other natural compounds-modulate oxidative in atherosclerosis. It examines their effects on key molecular pathways, including inhibition reactive oxygen species (ROS) production, suppression nuclear factor-κB (NF-κB), modulation cytokines. By integrating current knowledge, this underscores therapeutic dietary supplemental complementary strategies for managing atherosclerosis, paving way future research clinical applications.

Язык: Английский

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Current Advances in the Therapeutic Potential of Scutellarin: Novel Applications, Mechanisms, and Future Challenges.

Phytomedicine Plus, Год журнала: 2025, Номер unknown, С. 100754 - 100754

Опубликована: Янв. 1, 2025

Язык: Английский

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L-Arginine and Nitric Oxide in Vascular Regulation—Experimental Findings in the Context of Blood Donation

Nutrients, Год журнала: 2025, Номер 17(4), С. 665 - 665

Опубликована: Фев. 13, 2025

This narrative review provides an analysis of the role nitric oxide (NO) and its precursors, particularly L-arginine, in vascular regulation health, with emphasis on findings from our experimental research animal models. NO serves as a critical mediator function, contributing to vasodilation, blood flow, prevention thrombosis. As primary precursor NO, L-arginine is essential for maintaining endothelial integrity, modulating mitochondrial reducing oxidative damage. synthesises data contextualises these within physiological challenges faced by donors, such repeated donation associated stress. It examines effects supplementation respiration, lipid peroxidation, microsomal oxidation different conditions, including differences age, gender, dietary interventions. The mechanisms which enhances production, improves elasticity, alleviates dysfunction caused reduced bioavailability are also investigated. By integrating insights existing literature, this perspective potential address specific needs donors. highlights importance personalised nutritional approaches enhancing donor recovery resilience. In addition, assesses wider implications mitigating stress preserving function. interplay between bioavailability, factors, adaptation donors highlighted, along identification current knowledge gaps recommendations future research. presenting both original evidence synthesis article therapeutic promoting health context donation.

Язык: Английский

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Synergistic Role of Vitamins and Bioactive Compounds in Sea Buckthorn

IntechOpen eBooks, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Sea buckthorn (SB) offers remarkable health benefits through the synergistic actions of its bioactive compounds. High levels vitamin C, carotenoids and flavonoids enhance neurogenesis, reduce neuroinflammation support collagen synthesis. This synergy extends to gut health, fostering beneficial bacteria reducing oxidative stress. SB’s balanced profile essential fatty acids further amplifies bioavailability effectiveness fat-soluble vitamins. Omega-7, for example, works in concert with E promote skin regeneration damage, while omega-3 omega-6 modulate inflammatory responses antioxidant functions vitamins A E. Rich antioxidants like polyphenols lycopene, SB combats damage supports cardiovascular solidifying status as a functional superfood.

Язык: Английский

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Dietary and lifestyle modifications for effective management of hypertension: A comprehensive review

Journal of Agriculture and Food Research, Год журнала: 2025, Номер unknown, С. 101750 - 101750

Опубликована: Фев. 1, 2025

Язык: Английский

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