Metabolites,
Год журнала:
2021,
Номер
11(9), С. 610 - 610
Опубликована: Сен. 8, 2021
Barley
sprouts
are
known
to
have
several
effective
physiological
activities.
In
this
study,
the
anti-obesity
effect
of
a
barley
sprout
hot
water
extract
(BSE)
was
confirmed.
Saponarin
quantitatively
analyzed
in
BSE
using
HPLC,
and
inhibitory
on
3T3-L1
pre-adipocyte
differentiation
into
adipocytes
confirmed
by
Oil
Red
O
staining,
TG
assay,
Western
blotting.
addition,
adipocyte
growth
through
glucose
uptake
lipolysis
adipocytes.
C57/BL/6N
mice
were
induced
obesity
with
high-fat
diet,
administered
confirm
an
animal
model.
Weight
gain,
morphological
changes
adipose
tissue,
food
efficiency
ratio,
blood
biochemical
observed,
improvement
fatty
liver
As
result,
vitro,
it
that
also
vivo
could
be
helpful
treatment
obesity-related
diseases.
New
strategies
to
block
the
immune
evasion
activity
of
programmed
death
ligand-1
(PD-L1)
are
urgently
needed.When
exploring
PD-L1-targeted
effects
mechanistically
diverse
metabolism-targeting
drugs,
exposure
dietary
polyphenol
resveratrol
(RSV)
revealed
its
differential
capacity
generate
a
distinct
PD-L1
electrophoretic
migration
pattern.Using
biochemical
assays,
computer-aided
docking/molecular
dynamics
simulations,
and
fluorescence
microscopy,
we
found
that
RSV
can
operate
as
direct
inhibitor
glyco-PD-L1-processing
enzymes
(α-glucosidase/α-mannosidase)
modulate
N-linked
glycan
decoration
PD-L1,
thereby
promoting
endoplasmic
reticulum
retention
mannose-rich,
abnormally
glycosylated
form
PD-L1.RSV
was
also
predicted
interact
with
inner
surface
involved
in
interaction
PD-1,
almost
perfectly
occupying
target
space
small
compound
BMS-202
binds
induces
dimerization
PD-L1.The
ability
directly
interferes
stability
trafficking,
ultimately
impeding
targeting
cancer
cell
plasma
membrane.Impedance-based
real-time
analysis
(xCELLigence)
showed
cytotoxic
T-lymphocyte
notably
exacerbated
when
cells
were
previously
exposed
RSV.This
unforeseen
immunomodulating
mechanism
might
illuminate
new
approaches
restore
T-cell
function
by
PD-1/PD-L1
immunologic
checkpoint
natural
polyphenols.
Nutrients,
Год журнала:
2023,
Номер
15(20), С. 4486 - 4486
Опубликована: Окт. 23, 2023
Resveratrol
is
a
stilbenoid
from
red
grapes
that
possesses
strong
antioxidant
activity.
has
been
shown
to
have
anticancer
activity,
making
it
promising
drug
for
the
treatment
and
prevention
of
numerous
cancers.
Several
in
vitro
vivo
investigations
validated
resveratrol’s
capabilities,
demonstrating
its
ability
block
all
steps
carcinogenesis
(such
as
initiation,
promotion,
progression).
Additionally,
resveratrol
found
auxiliary
pharmacological
effects
such
anti-inflammatory,
cardioprotective,
neuroprotective
Despite
properties,
several
obstacles,
poor
solubility
bioavailability,
well
adverse
effects,
continue
be
key
obstacles
development.
This
review
critically
evaluates
clinical
trials
date
aims
develop
framework
into
clinically
viable
drug.
Current Topics in Medicinal Chemistry,
Год журнала:
2023,
Номер
23(8), С. 589 - 617
Опубликована: Янв. 9, 2023
Abstract:
A
sedentary
lifestyle
has
evoked
a
high
risk
of
cardiovascular
(CV)
disease,
diabetes,
and
obesity,
all
them
with
morbimortality
rates
common
denominator,
hypertension.
Numerous
pharmacological
drugs
have
been
used
for
the
treatment
However,
side
effects
associated
use
existing
therapies
triggered
demand
plant-based
medications.
In
this
connection,
aim
review
was
to
provide
an
in-depth
analysis
plant-derived
bioactives
effective
management
Phyto-constituents
from
leaves,
bark,
stem,
roots,
seeds,
fruits
medicinal
plants
grown
in
our
differ-ent
regions
globe
highly
searched.
Among
them,
polyphenols
(e.g.,
flavonoids
as
quercetin,
anthocyanins
cyanidin,
tannins
ellagic
acid,
stilbenes
resveratrol,
lignans
honokiol
others
hydroxytyrosol
or
curcumin),
organosulfur
compounds
(e.g.
s-allyl
cysteine
allicin),
fatty
acids
α-lipoic
DHA
oleic
acid),
alkaloids
berberine
tetran-drine)
some
terpenes
intensively
investigated
hypertension,
ability
being
stated
controlling
blood
pressure
related
health
problems
both
vivo
vitro
studies.
Some
activities
presented
by
these
bioactive
are
reducing
oxidative
stress,
renin-angiotensin
system
control,
SIRT1
activation,
regulating
platelet
aggregation
COX
activity,
anti-atherogenic
effects,
anti-inflammatory
properties,
vasorelaxa-tion
other
results
that
translate
into
prevention
control
The
knowledge
is
important
developing
countries
where
traditional
medicine
majority,
but
it
can
also
give
rise
new
approaches
hypertension
therapy.
Food Science & Nutrition,
Год журнала:
2024,
Номер
12(4), С. 2240 - 2258
Опубликована: Янв. 28, 2024
Abstract
Resveratrol,
a
natural
polyphenol
in
various
plants,
has
gained
significant
attention
for
its
potential
health‐promoting
properties.
It
been
demonstrated,
after
reviewing
clinical
and
vitro
studies,
that
resveratrol
possesses
potent
antioxidant
potential.
Resveratrol
demonstrates
cellular
component
protection
by
directly
neutralizing
free
radicals
(FRs)
enhancing
the
expression
of
enzymes,
thereby
mitigating
oxidative
damage
to
proteins,
lipids,
nucleic
acids.
Clinical
trials
have
shown
promising
results,
indicating
supplementation
can
enhance
defenses
reduce
markers
populations.
In
addition
effects,
exhibits
anti‐inflammatory
modulate
key
inflammatory
pathways,
such
as
nuclear
factor‐kappa
B
(NF‐κB)
mitogen‐activated
protein
kinases
(MAPKs),
suppressing
production
pro‐inflammatory
cytokines
chemokines.
Furthermore,
resveratrol's
multimodal
effects
extend
beyond
discovered
exert
regulatory
on
processes,
including
apoptosis,
cell
cycle
progression,
angiogenesis,
immunological
responses.
The
primary
aim
this
review
paper
is
provide
thorough
overview
current
knowledge
resveratrol,
chemical
composition,
bioaccessibility,
effectiveness,
utilization
nanotechnology
bioavailability.
From
future
perspectives,
revising
administration
methods
certain
contexts
understanding
underlying
systems
responsible
will
require
further
inquiry.
For
highest
health
advanced
trial‐based
research
necessary
combinational
nano‐delivery
resveratrol.
Sustainable Food Technology,
Год журнала:
2023,
Номер
1(2), С. 228 - 262
Опубликована: Янв. 1, 2023
The
increase
in
non-biodegradable
waste
has
prompted
research
on
the
development
of
new
biodegradable
compounds
that
can
act
as
substitutes
for
prevalent
synthetic
materials
used
packaging.
