Estimation of health risks associated with dietary cadmium exposure

Archives of Toxicology, Год журнала: 2023, Номер 97(2), С. 329 - 358

Опубликована: Янв. 2, 2023

Язык: Английский

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Cadmium Exposure: Mechanisms and Pathways of Toxicity and Implications for Human Health

Toxics, Год журнала: 2024, Номер 12(6), С. 388 - 388

Опубликована: Май 26, 2024

Cadmium (Cd), a prevalent environmental contaminant, exerts widespread toxic effects on human health through various biochemical and molecular mechanisms. This review encapsulates the primary pathways which Cd inflicts damage, including oxidative stress induction, disruption of Ca2+ signaling, interference with cellular signaling pathways, epigenetic modifications. By detailing absorption, distribution, metabolism, excretion (ADME) Cd, alongside its interactions components such as mitochondria DNA, this paper highlights extensive damage caused by Cd2+ at tissue levels. The role in inducing stress—a pivotal mechanism behind toxicity—is discussed emphasis how it disrupts balance between oxidants antioxidants, leading to apoptosis. Additionally, covers Cd’s impact like Mitogen-Activated Protein Kinase (MAPK), Nuclear Factor kappa-light-chain-enhancer activated B cells (NF-κB), Tumor 53 (p53) illustrating these contributes pathological conditions carcinogenesis. DNA methylation histone modifications, are also explored explain long-term gene expression disease manifestation. comprehensive analysis not only elucidates mechanisms toxicity but underscores critical need for enhanced strategies mitigate public implications.

Язык: Английский

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Neuroinflammation and neurodegeneration in Huntington’s disease: genetic hallmarks, role of metals and organophosphates

Neurogenetics, Год журнала: 2025, Номер 26(1)

Опубликована: Янв. 17, 2025

Язык: Английский

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Probiotics and gut microbiome − Prospects and challenges in remediating heavy metal toxicity

Journal of Hazardous Materials, Год журнала: 2021, Номер 420, С. 126676 - 126676

Опубликована: Июль 17, 2021

Язык: Английский

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Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain

Frontiers in Cell and Developmental Biology, Год журнала: 2020, Номер 8

Опубликована: Ноя. 30, 2020

Cadmium (Cd) is a well-known heavy metal and environmental toxicant pollutant worldwide, being largely present in every kind of item such as plastic (toys), battery, paints, ceramics, contaminated water, air, soil, food, fertilizers, cigarette smoke. Nowadays, it represents an important research area for the scientific community mainly its effects on public health. Due to half-life ranging between 15 30 years, Cd owns ability accumulate organs tissues, exerting deleterious effects. Thus, even at low doses, prolonged exposure may cause multiorgan toxicity. Mitochondria are key intracellular targets Cd-induced cytotoxicity, but underlying mechanisms not fully elucidated. The review aimed clarify mitochondria and, particularly, mitochondrial electron transport chain.

Язык: Английский

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Environmental exposure of the general population to cadmium as a risk factor of the damage to the nervous system: A critical review of current data

Journal of Applied Toxicology, Год журнала: 2022, Номер 43(1), С. 66 - 88

Опубликована: Март 19, 2022

Abstract Nowadays, more and attention has been focused on the risk of neurotoxic action cadmium (Cd) under environmental exposure. Due to growing incidence nervous system diseases, including neurodegenerative changes, suggested involvement Cd in their aetiopathogenesis, this review aimed discuss critically element neurotoxicity. Attempts have made recognize at which concentrations blood urine may increase damage compare it injury other organs systems. The performed overview available literature shows that an unfavourable impact human's concentration >0.8 μg Cd/L >0.6 blood. Because such are currently noted general population industrialized countries, can be concluded exposure xenobiotic create a involved aetiopathogenesis as Alzheimer's disease Parkinson's disease, well worsening cognitive behavioural functions. potential mechanism neurotoxicity consists inducing oxidative stress, disrupting activity enzymes essential proper functioning destroying homoeostasis bioelements brain. Thus, further studies necessary accurately both due action.

Язык: Английский

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Beneficial effects of Chrysin on Cadmium‐induced nephrotoxicity in rats: Modulating the levels of Nrf2/HO‐1, RAGE/NLRP3, and Caspase-3/Bax/Bcl-2 signaling pathways

Gene, Год журнала: 2023, Номер 875, С. 147502 - 147502

Опубликована: Май 22, 2023

Язык: Английский

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Microglial Activation in Metal Neurotoxicity: Impact in Neurodegenerative Diseases

BioMed Research International, Год журнала: 2023, Номер 2023(1)

Опубликована: Янв. 1, 2023

Neurodegenerative processes encompass a large variety of diseases with different pathological patterns and clinical features, such as Alzheimer’s Parkinson’s diseases. Exposure to metals has been hypothesized increase oxidative stress in brain cells leading cell death neurodegeneration. Neurotoxicity demonstrated by several vitro vivo experimental studies, most probably, each metal its specific pathway trigger death. As result, exposure essential metals, manganese, iron, copper, zinc, cobalt, nonessential including lead, aluminum, cadmium, perturbs homeostasis at the cellular organism levels In this contribution, comprehensive review molecular mechanisms which affect microglia physiology signaling properties is presented. Furthermore, studies that validate disruption activation pathways an mechanism toxicity can contribute neurodegenerative disease are also presented discussed.

Язык: Английский

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Human Health Effects of Chronic Cadmium Exposure

Опубликована: Янв. 1, 2024

Cadmium (Cd) is a hazardous unnecessary transition metal that harmful to people and animals. naturally prevalent in the environment frequently obtained from agriculture industrial processes. Humans are typically exposed Cd through filthy food water, inhalation, cigarette smoking. stored plants animals has lengthy half-life of 25–30 years. Observational l evidence suggests occupational environmental exposure may be connected malignancies breast, lung, prostate, nasopharynx, pancreas, kidney, as well an increased risk osteoporosis. Because their capacity generate metallothioneins (MT), which Cd-inducible proteins protect cells, liver kidneys particularly sensitive effects Cd. Cadmium-induced oxidative stress likely contribute variety kidney illnesses, mitochondrial damage possible mechanism, these organelles play important role generation reactive oxygen species (ROS) intracellular targets for The determination dietary consumption critical step estimating body burden associated health consequences. Chronic known have substantial influence on kidneys, most vulnerable toxicity. Urinary (UC), proportional relationship between accumulation excretion via urine, reliable indicator exposure. This chapter outlines numerous pathways exposure, impact human health, use several biomarkers measure

Язык: Английский

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Non-essential heavy metal effects in cardiovascular diseases: an overview of systematic reviews

Frontiers in Cardiovascular Medicine, Год журнала: 2024, Номер 11

Опубликована: Янв. 23, 2024

Introduction Cardiovascular diseases (CVDs) are the most important cause of premature death and disability worldwide. Environmental degradation cardiovascular two keys to health challenges, characterized by a constant evolution in an industrialized world that exploits natural resources regardless consequences for health. The etiological risk factors CVDs widely known include dyslipidemia, obesity, diabetes, chronic cigarette consumption. However, one component is often underestimated exposure heavy metals. biological perspective explains different metals play roles. They therefore classified into essential metals, which present organisms where they perform vital functions, especially various physiological processes, or non-essential with no role but, nonetheless, remain environment absorbed. Although both types metal ions many times chemically similar can bind same ligands, attention given today nonessential several eukaryotic species starting raise strong concerns due exponential increase their concentrations. aim this systematic review was assess possible correlations between increased incidence disease, reporting results studies published last 5 years through March 2023. Methods includes reviews retrieved from PubMed, Medline, Embase, Web Science databases, accordance PRISMA (Preferred Reporting Items Systematic Reviews Meta-Analyses) statement following PICO (Population Intervention Comparison Outcome Population) framework. Results Eight reviews, including total 153 studies, were identified. Seven these enlighted association exposure. Discussion It evident represent factor onset. further needed better understand effects caused

Язык: Английский

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