Ozonized gels vs chlorhexidine in non‐surgical periodontal treatment: A randomized clinical trial

Oral Diseases, Год журнала: 2023, Номер 30(6), С. 3993 - 4000

Опубликована: Дек. 4, 2023

To evaluate the efficacy of newly introduced ozonated gels compared with conventional chlorhexidine gel in home management periodontal patients.

Язык: Английский

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From Pathogenesis to Intervention: The Importance of the Microbiome in Oral Mucositis

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(9), С. 8274 - 8274

Опубликована: Май 5, 2023

Oral mucositis (OM) is a common and impactful toxicity of standard cancer therapy, affecting up to 80% patients. Its aetiology centres on the initial destruction epithelial cells increase in inflammatory signals. These changes oral mucosa create hostile environment for resident microbes, with infections co-occurring OM, especially at sites ulceration. Increasing evidence suggests that microbiome occur beyond opportunistic infection, growing appreciation potential role OM development severity. This review collects latest articles indexed PubMed electronic database which analyse bacterial shift through 16S rRNA gene sequencing methodology patients under treatment mucositis. The aims are assess whether gut causally contribute or if they simply consequence mucosal injury. Further, we explore emerging patient’s microbial fingerprint prediction. maintenance bacteria via target therapy constant improvement should be considered treatment.

Язык: Английский

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Calcium Antagonist-Induced Gingival Overgrowth: A Case Report and Literature Review

Diagnostics, Год журнала: 2025, Номер 15(3), С. 320 - 320

Опубликована: Янв. 30, 2025

Background: Drug-induced gingival enlargement is a commonly documented adverse effect in patients administered with calcium antagonist medications. Nifedipine the medicine most frequently linked to instances of enlargement; nevertheless, amlodipine, likewise antagonist, can elicit this effect. This case report aims detail amlodipine-induced hyperplasia, emphasizing significance multidisciplinary approach and outlining its therapy across various surgical phases. Methods: A 48-year-old hypertensive patient using amlodipine presents aberrant tissue growth upper arch. Intraoral examination reveals localized inflammation papillae areas arch gingiva, leading partial covering dental crowns. The experienced painful sensations episodes spontaneous bleeding enlarged tissue. Following an initial professional hygiene treatment, which included root planning quadrants, consultation referring cardiologist, it was determined discontinue initiate replacement olmesartan medoxomil. Fifteen days following cessation excision thickened interdental tissues anterior region conducted obtain biopsies for histological confirmation observed pathological condition. Results: Histopathological validated diagnosis drug-induced enlargement, characterized by chorion fibrosis significant lymphoplasmacytic infiltration. Specifically, parakeratotic acanthotic characteristics were seen epithelium. Adjacent inflammatory regions, noted, along presence cytoid bodies, are typically diseases driven processes. These consistent enlargement. Conclusions: involving treating physician, dentist, hygienist, incorporating drug targeted oral sessions, crucial management resolution channel blocker-induced

Язык: Английский

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In Vivo Biofilm Formation on Novel PEEK, Titanium, and Zirconia Implant Abutment Materials

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(2), С. 1779 - 1779

Опубликована: Янв. 16, 2023

The formation of biofilms on the surface dental implants and abutment materials may lead to peri-implantitis subsequent implant failure. Recently, innovative such as polyether-ether-ketone (PEEK) its modifications have been used materials. However, there is limited knowledge microbial adhesion PEEK aim this in vivo study was investigate biofilm conventional (titanium zirconia) Split specimens titanium, zirconia, PEEK, modified (PEEK-BioHPP) were manufactured, mounted individual removable acrylic upper jaw splints, worn by 20 healthy volunteers for 24 h. roughness determined using widefield confocal microscopy. Biofilm accumulation investigated fluorescence microscopy quantified imaging software. <0.2 µm showed no significant differences between Zirconia lowest formation, followed PEEK-BioHPP. Differences (p < 0.001) materials, except polyether-ether-ketones. Generally, significantly higher 0.05) posterior region oral cavity than anterior region. results present show a material-dependent susceptibility formation. risk developing be reduced specific choice material.

Язык: Английский

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Periodontal disease in down syndrome: Predisposing factors and potential non‐surgical therapeutic approaches

Journal of Clinical Laboratory Analysis, Год журнала: 2024, Номер 38(1-2)

Опубликована: Янв. 1, 2024

Abstract Background Periodontal diseases (PDs) have been documented to be significantly more prevalent and severe in patients with Down syndrome (DS). Different immunological microbiological factors contributed predisposing these progressive recurrent PDs. Aim The aim of this review was investigate the altered responses oral microbiota disorders as well focus on adjunctive non‐surgical methods for treatment PDs its applicability DS. Material Methods A literature conducted addressing following topics: (1) responses, (2) orofacial related DS patients, (3) changing, (4) efficacy Results Due early onset children DS, need prompt effective is essential. Discussion Conclusion So, investigating underlying may open a new window better understand pathology people thus, find strategies such group. Although treatments photodynamic therapy probiotic consumption represented acceptable outcomes different examined without data about application convenience no local anesthesia limited.

Язык: Английский

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Full-Arch Rehabilitation Using Trans-Mucosal Tissue-Level Implants with and without Implant-Abutment Units: A Case Report

Dentistry Journal, Год журнала: 2022, Номер 10(7), С. 116 - 116

Опубликована: Июль 1, 2022

Recently, tissue-level implants with a convergent collar have been introduced. While different studies investigated the outcomes of this implant design in rehabilitation single teeth, its use full-arch has yet to be investigated. The present case report describes clinical immediate loading using implants, and without implant-abutment units, 2 years follow-up. A female patient mandibular terminal dentition high level bone resorption (distal areas few millimeters residual vertical dimension both distal anterior narrow crestal horizontal dimension) was seen at C.I.R Dental School, Turin, Italy. seeking rehabilitated fixed prosthodontics, she found eligible for an rehabilitation. Four were inserted same appointment. two straight connected directly prosthesis (no abutments); tilted order avoid alveolar nerve 30° angulated abutments. Two post-implant placement, all successfully integrated, resulting survival rate 100%. peri-implant soft tissues stable sites. No differences highlighted between those Within limitations report, rehabilitations units showed optimal after Further research is encouraged confirm whether may valid alternative traditional type rehabilitation, or units.

Язык: Английский

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Influence of Smoking on Periodontal and Implant Therapy: A Narrative Review

International Journal of Environmental Research and Public Health, Год журнала: 2023, Номер 20(7), С. 5368 - 5368

Опубликована: Апрель 3, 2023

Background: smoking is considered the most modifiable risk factor for periodontal disease. Objective: aim of this narrative review to emphasize effect on and implant therapy. Methods: The authors reviewed literature reporting clinical outcomes surgical nonsurgical treatment. impact therapy sinus lifting procedures were also reviewed. Results: Periodontal are adversely affected by smoking. Smokers respond less favorably flap as compared nonsmokers. Clinical smokers 50–75% worse than Studies reveal that experience a significantly lower reduction in pocket depth nonsmokers well bone growth after treating infra-bony defects with guided tissue regeneration. relative failure higher patients who smoke 20 cigarettes or more per day Additionally, has been shown increase postoperative wound dehiscence infection rates following floor elevation. Longitudinal studies cessation have loss probing depths periodontitis those smoke. Conclusion: Smoking can reduce improve attachment There insufficient evidence regarding peri-implantitis, implants long-term.

Язык: Английский

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Standardization of the protocol for oral cavity examination and collecting of the biological samples for microbiome research using the next-generation sequencing (NGS): own experience with the COVID-19 patients

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Фев. 14, 2024

Abstract To date, publications have shown that compositions of oral microbiota differ depending on their habitats (e.g. tongue, tonsils, pharynx). The absence set standards for the choice areas and conditions material collection makes microbiome one most difficult environments a comparative analysis with other researchers, which is meaningful limitation during an assessment potential effects microorganisms as biomarkers in courses various human diseases. Therefore, standardisation basic dental examination next generation sequencing (NGS) worth attempting. exam clinical materials: saliva, swab from tongue ridge, hard palate, palatine tonsils oropharynx, supragingival plaque subgingival plaque. Protocol involved patients (n = 60), assigned to 3 groups: I—COVID-19 convalescents who received antibiotics, n 17, II—COVID-19 convalescents, 23 III—healthy individuals, 20. collected biological samples were used conduct NGS (16S rRNA). patient preparation collecting materials well schedule examination, proposed. Based research conducted, we indicated indicators best differentiate group COVID-19 (groups I II) healthy people (group III). These include DMFT, D BOP indices. use alpha beta diversity provided overall insight into microbial communities between specific niches groups. different studied III) was noted relation order activities while securing particularly important avoid technical errors contamination may result erroneous conclusions analyses results sensitive tests such NGS. It has been indices: number, PI are prognostic parameters assess health. niche susceptible changes composition procedures developed by our team can be applied ready-to-use forms studies conducted researchers.

Язык: Английский

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Dual-functionalized titanium by ultrafast laser texturing to enhance human gingival fibroblasts adhesion and minimize Porphyromonas gingivalis colonization

Applied Surface Science, Год журнала: 2022, Номер 606, С. 154784 - 154784

Опубликована: Сен. 7, 2022

Язык: Английский

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Impact of Smoking on Salivary Lipid Profile and Oxidative Stress in Young Adults: A Comparative Analysis between Traditional Cigarettes, E-Cigarettes, and Heat-Not-Burn Products

Medical Science Monitor, Год журнала: 2023, Номер 30

Опубликована: Ноя. 20, 2023

Background:Smoking nicotine is considered to be one of the most harmful addictions, leading development a number health complications, including many pathologies in oral cavity.The aim this study was examine effect smoking traditional cigarettes, e-cigarettes, and heat-not-burn products on profiles salivary lipids lipid peroxidation unstimulated stimulated saliva healthy young adults with habit up 3 years. Material/Methods:We enrolled groups 25 patients each control group matched for age, gender, status.In collected from participants group, concentrations sphingolipids: sphingosine, sphinganine, sphingosine-1-phosphate, ceramides, -malondialdehyde (MDA) 4-hydroxynonenal (HNE) -were measured.The normality distribution assessed using Shapiro-Wilk test.For comparison results, one-way analysis variance (ANOVA) followed by post hoc Tukey test used. Results:We demonstrated that type causes decrease concentration lipids, there an increased MDA 4-HNE. Conclusions:Smoking initial period addiction leads increase through oxidative stress, disturbance balance cavity (eg, due damage cell membranes).

Язык: Английский

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