Targeting overexpressed surface proteins: A new strategy to manage the recalcitrant triple-negative breast cancer

European Journal of Pharmacology, Год журнала: 2024, Номер 981, С. 176914 - 176914

Опубликована: Авг. 22, 2024

Язык: Английский

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In Vitro Antiproliferative Activity of Echinulin Derivatives from Endolichenic Fungus Aspergillus sp. against Colorectal Cancer

Molecules, Год журнала: 2024, Номер 29(17), С. 4117 - 4117

Опубликована: Авг. 30, 2024

The endolichenic fungus Aspergillus sp. was isolated from the lichen Xanthoparmelia conspersa harvested in France. grown on a solid culture medium to ensure large-scale production of with sufficient mass secondary metabolites. molecular network analysis extracts and subfractions enabled annotation 22 molecules, guiding purification process. EtOAc extract displayed an antiproliferative activity 3.2 ± 0.4 µg/mL at 48 h against human colorectal cancer cells (HT-29) no toxicity 30 triple-negative breast (TNBC) (MDA-MB-231) embryonic kidney (HEK293) non-cancerous cells. Among five prenylated compounds isolated, which four are echinulin derivatives, 1 2 showed most important activity, IC50 values 1.73 µM 8.8 µM, respectively, HT-29

Язык: Английский

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Silver N-Heterocyclic Carbene (NHC) Complexes as Antimicrobial and/or Anticancer Agents

Pharmaceuticals, Год журнала: 2024, Номер 18(1), С. 9 - 9

Опубликована: Дек. 25, 2024

The strict connections/interactions between microbial infections and cancer are nowadays widely accepted. Hence, the dual (or multiple) targeting of is an essential issue to be addressed. In this context, metal complexes have gained considerable importance effectiveness in medicinal chemistry. Particularly, N-heterocyclic carbene (NHC) with transition metals emerged as very promising compounds. Among myriad NHC–metal complexes, those bearing silver will subject review. Numerous Ag(I)-NHC revealed high antibacterial and/or anticancer properties, even higher than reference drugs. Herein, we summarize most recent studies while also discussing proposed mechanism action offering interesting remark about research field. Literature databases (PubMed/MEDLINE, Scopus, Google Scholar) were used sources search literature, referring last five years.

Язык: Английский

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Biomarkers derived from CmP signal network in triple negative breast cancers

Translational Breast Cancer Research, Год журнала: 2023, Номер 4, С. 21 - 21

Опубликована: Июль 1, 2023

Breast cancer is the most commonly diagnosed and second leading cause of cancerrelated death in women, accounting for approximately 30% all new cases.The prognosis breast heavily depends on stage diagnosis, with early detection resulting higher survival rates.Various risk factors, including family history, alcohol consumption hormone exposure, contribute to development.Triple-negative (TNBC), characterized by absence certain receptors, particularly aggressive heterogeneous.Cerebral cavernous malformations (CCMs), abnormal dilations small blood vessels brain, contributed mutated genes like CCM1, CCM2, CCM3 through perturbed formation CCM signaling complex (CSC).The CSC-non-classic membrane progesterone receptors (mPRs)-progesterone (PRG) (CmP)/CSC-mPRs-PRG-classic nuclear (nPRs) (CmPn) network, which integrates CSC mPRs nPRs, plays a role tumorigenesis.Understanding these pathways can provide insights into potential treatments.This paper focuses emerging field CmPn/CmP signal networks, involve PRG, its (nPRs mPRs), CSC.These networks play tumorigenesis, TNBCs.Aims deliver thorough examination CmP/CmPn concerning TNBCs, this provides comprehensive overview pathways, explores their applications highlights significance context TNBCs.

Язык: Английский

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