Chemical Profiling and In Vitro Evaluation of Bioactive Properties of Evernia prunastri Extract: Implications for Therapeutic Applications DOI Creative Commons
Dejan Stojković, Jelena Živković, Stefani Bolevich

и другие.

Plants, Год журнала: 2025, Номер 14(4), С. 583 - 583

Опубликована: Фев. 14, 2025

Evernia prunastri (L.) Ach. (Parmeliaceae), an edible lichen commonly known as oakmoss, was traditionally used by Egyptians to make bread. In this study, the ethyl-acetate (EtOAc) extract of E. investigated for its potential therapeutic applications in diabetes mellitus, Alzheimer's and Parkinson's diseases, oxidative stress, bacterial infections. The exhibited significant vitro enzyme inhibition activities, including anti-amylase anti-glucosidase activities linked anti-cholinesterase anti-tyrosinase associated with diseases. antioxidant activity evaluated through multiple assays, free radical scavenging (DPPH ABTS), reducing power (CUPRAC FRAP), metal chelation, phosphomolybdenum methods, demonstrating strong stress relief potential. antibacterial properties were also confirmed testing, showing efficacy against a range strains. Total phenolic flavonoid contents quantified, while chemical profile EtOAc determined LC-HRMS/MS analysis. composition predominantly characterized depsides (evernic acid atranorin), acids (orsellinic acid), dibenzofurans, revealing diverse array bioactive secondary metabolites. demonstrated broad spectrum biological inhibition, effects, properties. This study highlights functional food, providing rich source compounds numerous health-promoting it suggests relevance chronic diseases such diabetes, Alzheimer's,

Язык: Английский

An expanded database of high-resolution MS/MS spectra for lichen-derived natural products DOI Creative Commons
Joe Bracegirdle,

John A. Elix,

Udayangani Mawalagedera

и другие.

Scientific Data, Год журнала: 2025, Номер 12(1)

Опубликована: Фев. 12, 2025

Abstract The history of lichen compound identification has long relied on techniques such as spot tests and TLC, which have been surpassed in sensitivity accuracy by modern metabolomic high-resolution MS/MS. In 2019, Olivier-Jimenez et al . released the Lichen DataBase (LDB), a library containing Q-TOF MS/MS spectra 251 metabolites MetaboLights GNPS platforms, that widely used for lichen-derived unknowns. To increase coverage, we generated Orbitrap further 534 compounds from metabolite Jack Elix, housed at CANB herbarium (Canberra, Australia). This included 399 unique are not LDB, bringing total number combined to 650. Technical validation was achieved investigating three Australian extracts using Library Search Molecular Networking tools platform. update provides much larger database identification, envisage will allow refining chemotaxonomy framework contribute discovery.

Язык: Английский

Процитировано

0
Chemical Profiling and In Vitro Evaluation of Bioactive Properties of Evernia prunastri Extract: Implications for Therapeutic Applications DOI Creative Commons
Dejan Stojković, Jelena Živković, Stefani Bolevich

и другие.

Plants, Год журнала: 2025, Номер 14(4), С. 583 - 583

Опубликована: Фев. 14, 2025

Evernia prunastri (L.) Ach. (Parmeliaceae), an edible lichen commonly known as oakmoss, was traditionally used by Egyptians to make bread. In this study, the ethyl-acetate (EtOAc) extract of E. investigated for its potential therapeutic applications in diabetes mellitus, Alzheimer's and Parkinson's diseases, oxidative stress, bacterial infections. The exhibited significant vitro enzyme inhibition activities, including anti-amylase anti-glucosidase activities linked anti-cholinesterase anti-tyrosinase associated with diseases. antioxidant activity evaluated through multiple assays, free radical scavenging (DPPH ABTS), reducing power (CUPRAC FRAP), metal chelation, phosphomolybdenum methods, demonstrating strong stress relief potential. antibacterial properties were also confirmed testing, showing efficacy against a range strains. Total phenolic flavonoid contents quantified, while chemical profile EtOAc determined LC-HRMS/MS analysis. composition predominantly characterized depsides (evernic acid atranorin), acids (orsellinic acid), dibenzofurans, revealing diverse array bioactive secondary metabolites. demonstrated broad spectrum biological inhibition, effects, properties. This study highlights functional food, providing rich source compounds numerous health-promoting it suggests relevance chronic diseases such diabetes, Alzheimer's,

Язык: Английский

Процитировано

0