Leech bionic Hirudin fusion protein prodrug loaded microneedles for long-term inhibition of thrombosis

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113759 - 113759

Опубликована: Апрель 1, 2025

Язык: Английский

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Effect of Nanohydroxyapatite on Silk Fibroin-Chitosan Interactions. Molecular Dynamics Study

Опубликована: Апрель 3, 2024

Fibroin-chitosan composites, especially those containing nanohydroxyapatite, show potential for bone tissue regeneration. The physicochemical properties of these biocomposites depend on the compatibility between their components. In this study, intermolecular interactions fibroin and chitosan were analyzed using a molecular dynamics approach. Two types systems investigated: one acetic acid other calcium (Ca²⁺) hydrogen phosphate (HPO₄²⁻) ions mimicking hydroxyapatite conditions. After obtaining optimal equilibrium structures, distributions several including bonds, ionic contacts, hydrophobic contacts along with structural energetical features examined. calculated binding energy values fibroin-chitosan complexes confirm remarkable stability. high affinity can be explained by formation dense network considered biopolymers. These found to primarily bonds involving ALA, ARG, ASN, ASP, GLN, GLU, GLY, LEU, PRO, SER, THR, TYR, VAL residues. As it was established, complexation maintains β-sheet conformation peptide. β-Sheet fragments in are involved significant amount chitosan.

Язык: Английский

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Novel drug delivery systems for hirudin-based product development and clinical applications

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 287, С. 138533 - 138533

Опубликована: Дек. 8, 2024

Язык: Английский

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Effect of Nanohydroxyapatite on Silk Fibroin–Chitosan Interactions—Molecular Dynamics Study

Applied Sciences, Год журнала: 2024, Номер 14(10), С. 4131 - 4131

Опубликована: Май 13, 2024

Fibroin–chitosan composites, especially those containing nanohydroxyapatite, show potential for bone tissue regeneration. The physicochemical properties of these biocomposites depend on the compatibility between their components. In this study, intermolecular interactions fibroin and chitosan were analyzed using a molecular dynamics approach. Two types systems investigated: one acetic acid other calcium (Ca2+) hydrogen phosphate (HPO₄2−) ions mimicking hydroxyapatite conditions. After obtaining optimal equilibrium structures, distributions several interactions, including bonds, ionic contacts, hydrophobic along with structural energetical features, examined. calculated binding energy values fibroin–chitosan complexes confirm remarkable stability. high affinity can be explained by formation dense network considered biopolymers. These found to primarily bonds contacts involving ALA, ARG, ASN, ASP, GLN, GLU, GLY, LEU, PRO, SER, THR, TYR, VAL residues. As established, complexation maintains β-sheet conformation peptide. β-Sheet fragments in are involved significant number chitosan.

Язык: Английский

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Deposition of Cellulose Acetate Coatings on Titanium Substrates by Electrospraying for Biomedical Applications

Опубликована: Янв. 1, 2024

Functional coatings with incorporated antibacterial agents have gained interest in the field of implants, as they reduce complications associated infections and promote osseointegration. Biocompatible cellulose acetate were fabricated potential drug carriers on titanium substrates using electrospraying. For this purpose, six different concentrations used to fabricate coatings. Depending concentration solution, coating thicknesses obtained. The elasticity was tested a standardized series bending test. It has also been shown that sandblasting samples increases their surface roughness leads significant improvement adhesion coating. measured atomic force microscopy. To determine substrate, subjected tests. chemical composition near-surface layers studied X-ray photoelectron spectroscopy. Additionally, molecular structure investigated Fourier Transformed Infrared Raman spectroscopies. Examination by diffraction revealed each sample group are completely amorphous. Coatings prepared 10 12 wt.% best suited for use surfaces due mechanical properties uniformity.

Язык: Английский

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The influence of Fe2+ on the self-assembly of a bipyridine containing homopolymer: From bowl-shaped nanoparticles to vesicles

European Polymer Journal, Год журнала: 2024, Номер unknown, С. 113502 - 113502

Опубликована: Окт. 1, 2024

Язык: Английский

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Deposition of cellulose acetate coatings on titanium substrates by electrospraying for biomedical applications

Surface and Coatings Technology, Год журнала: 2024, Номер unknown, С. 131472 - 131472

Опубликована: Окт. 1, 2024

Язык: Английский

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