Unveiling potential functional applications of grape pomace extracts based on their phenolic profiling, bioactivities, and circular bioeconomy
Biomass Conversion and Biorefinery,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Abstract
Grape
pomace
(GP),
a
by-residue
from
the
wine
industry,
contains
bioactive
molecules
such
as
phenolic
compounds,
and
anthocyanins,
among
others,
with
potential
health
benefits.
In
current
study,
these
were
extracted
GP
of
different
Vitis
vinifera
L.
varieties
(Tinta
Negra,
Complexa,
Malvasia
Roxa,
Malvasia,
Sercial,
Verdelho,
Boal,
Terrantez)
using
micro
quick,
easy,
cheap,
effective,
rugged,
safe
(µQuEChERS)
procedure.
The
extracts
investigated
ultra-high
performance
liquid
chromatography
(UHPLC-PDA)
to
establish
fingerprint,
by
in
vitro
assays
assess
antibacterial,
anti-inflammatory,
antioxidant
activities.
Nine
compounds
identified
quantified
extracts,
gallic
acid
(ranging
10.4
12.9
g/100
g),
catechin
(2.97
5.08
quercetin
(2.17
2.85
trans
-resveratrol
(0.28
1.82
g)
being
most
prominent.
Complexa
variety
exhibited
highest
levels
total
anthocyanin
content
(TAC,
6.67
mgCGE/100
(TPC,
4727
mgGAE/100
activity
(DPPH,
9472
mgTE/100
while
Tinta
Negra
had
(TCC,
947
mgCATE/100
g).
A
strong
correlation
(
p
<
0.001)
was
observed
between
TPC-TAC,
TPC-DPPH,
DPPH-TAC,
TAC-TCC.
Moreover,
o-coumaric
are
significantly
correlated
TPC,
TAC,
TCC,
DPPH
assays.
at
concentration
100
µg/mL,
showed
promising
inhibition
albumin
protein
denaturation
compared
aspirin
(reference
standard).
findings
that
more
useful
inhibiting
Staphylococcus
aureus
Escherichia
coli
.
It
is
important
emphasise
demonstrated
antioxidant,
antibacterial
properties,
positioning
it
an
agro-waste
for
use
development
innovative
functional
foods,
dietary
supplements,
cosmetics,
aligning
circular
bioeconomy
model
its
valorisation.
Язык: Английский
Harnessing plant metabolic pathways for innovative diabetes management: unlocking the therapeutic potential of medicinal plants
Plant Signaling & Behavior,
Год журнала:
2025,
Номер
20(1)
Опубликована: Апрель 7, 2025
The
exploration
of
plant
signaling
pathways
is
transforming
the
way
diabetes
managed,
providing
new,
multi-target
strategies
for
controlling
this
complex
metabolic
disorder.
Medicinal
plants
are
rich
in
bioactive
compounds
like
phytohormones,
flavonoids
and
polyphenols,
which
regulate
key
including
oxidative
stress,
inflammation,
insulin
resistance,
gut
microbiota
modulation.
Research
emerging
on
therapeutic
potential
Momordica
charantia,
Cinnamomum
verum
Trigonella
foenum-graecum,
enhance
secretion,
sensitivity
glucose
homeostasis.
These
derived
compounds,
resveratrol
based
mimetics,
not
only
address
dysfunction
but
also
offer
holistic
treatment
long
term
complications
such
as
neuropathy
retinopathy.
development
precision
medicine
advances
tailoring
therapies
to
individual
responses,
increasing
efficacy
decreasing
reliance
synthetic
drugs
with
adverse
side
effects.
Despite
challenges
standardization,
regulatory
barriers,
limited
clinical
trials,
incorporating
medicinal
into
national
management
guidelines
represents
a
cost
effective
accessible
option,
particularly
resource
settings.
In
review,
we
highlight
importance
collaborative
work
across
disciplines
use
technologies
artificial
intelligence
speed
research
optimize
patient
specific
applications.
power
harnessed
develop
sustainable,
inclusive,
strategies.
Язык: Английский
Nephroprotective and anti-inflammatory effects of resveratrol topical ointment in albino rats following full-thickness cutaneous burn wound
Journal of Clinical and Translational Research,
Год журнала:
2024,
Номер
10(4), С. 00019 - 00019
Опубликована: Авг. 29, 2024
Background:
Recent
studies
on
resveratrol
(RSV)
have
generated
great
interest,
owing
to
its
pleiotropic,
health-promoting
properties
that
been
documented
not
only
in
animals
but
also
humans
exhibit
anti-neoplastic
and
alleviate
oxidative
stress
inflammation,
anti-diabetic,
protective
role
cardiac
diseases,
anti-ulcerative
properties,
among
others.
Aims:
This
study
is
aimed
at
evaluating
the
effects
of
topical
RSV
ointment
hematology,
serum
biochemistry,
vascular
endothelial
growth
factor
(VEGF),
following
full-thickness
cutaneous
burn
wound
(BW).
Methods:
Four
groups
15
rats
were
arranged
A
(negative
control),
B
(positive
drug
control;
BW
+
1%
silver
sulphadiazine
[SSD]
cream),
C
(experimental
group;
5%
application),
D
with
no
application
ointment).
The
dorsum
was
shaved
using
a
clipper,
23.5
mm
inflicted
B–D.
Rats
from
treated
twice
daily
for
21
days.
Five
each
group
anesthetized
days
5,
8,
21,
blood
samples
collected
post-wounding
(PW).
Results:
statistically
significant
reduction
neutrophil
monocyte
counts
RSV-treated
recorded
(P
<
0.05).
Increased
aspartate
aminotransferase
(AST),
alanine
(ALT),
alkaline
phosphatase
(ALP)
activities
day
5
due
acute
hepatic
injury
associated
burns
normalized
8
21.
Serum
levels
urea
creatinine
lower
than
SSD-treated
post-treatment
(PT).
had
VEGF
concentration
comparison
other
groups.
Conclusion:
demonstrated
suppresses
peripheral
circulation,
thus
acting
as
an
anti-inflammatory
compound.
Similarly,
exhibited
nephroprotective
effect
by
suppressing
levels.
reportedly
suppressed
activity
VEGF,
making
it
good
antineoplastic
agent.
Relevance
Patients:
formulation
can
be
used
enhance
healing
human
patients
through
effect.
ameliorate
kidney
dysfunction
patients.
Язык: Английский
Network Pharmacology, Molecular Docking, and Molecular Dynamics Study to Explore the Effect of Resveratrol on Type 2 Diabetes
Journal of Cellular Biochemistry,
Год журнала:
2024,
Номер
126(1)
Опубликована: Сен. 20, 2024
ABSTRACT
This
network
pharmacology
study
represents
a
significant
step
in
understanding
the
potential
of
Resveratrol
as
an
antidiabetic
agent
and
its
molecular
targets.
Targets
for
Type
2
diabetes
were
obtained
from
MalaCards
DisGeNET
databases,
while
targets
sourced
STP
CTD
databases.
Subsequently,
we
performed
matching
to
identify
common
disease‐compound
The
identified
genes
analyzed
using
ShinGO‐0.76.3
database
functional
enrichment
analysis
KEGG
pathway
mapping.
A
protein−protein
interaction
was
then
constructed
Cytoscape
software,
hub
identified.
These
subjected
docking
dynamic
simulations
AutoDock
Vina
Gromacs
software.
According
analysis,
influences
insulin
receptors,
endoplasmic
reticulum
functions,
oxidoreductase
activity
is
involved
estrogen
HIF‐1
pathways.
Ten
identified,
including
ESR1
,
PTGS2
SRC
NOS3
MMP9
IGF1R
CYP19A1
MTOR
MMP2,
PIK3CA
.
proteins
associated
with
these
exhibited
high
dynamics
showed
stable
ESR1,
MMP9,
PIK3CA,
PTGS2.
In
conclusion,
our
work
enhances
Resveratrol,
which
future
studies
should
experimentally
corroborate.
Язык: Английский
Resveratrol and Curcumin: Extending the Frontier of Phytomedicine
IntechOpen eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 16, 2024
The
health
of
the
oral
cavity
is
a
starting
point
for
overall
health,
and
systemic
inflammation
can
arise
when
compromised,
leading
to
an
increased
risk
developing
cardiovascular,
metabolic,
autoimmune,
neurodegenerative
disease
or
cancer.
Fortunately,
nature
has
provided
us
with
bioactive
molecules
like
polyphenols,
such
as
curcumin
resveratrol,
which
have
demonstrated
capacity
immunomodulation,
regeneration,
repair.
One
challenges
biomedical
scientific
community
that
delayed
actualization
full
potential
phytochemicals
resveratrol
potent
therapeutic
agents
fact
they
display
low
bioavailability,
instability,
rapid
clearance,
making
them
unsuitable
medicines
by
modern
pharmacological
standards.
Thankfully,
application
nanotechnological
design
viable
solution
poor
profile
their
clinical
translation
feasible
emergence
in
near
future.
Язык: Английский
Unraveling the effect of high pressure homogenization treatment combined with polyphenols on the improvement of emulsion stability of rice bran oil bodies
Food Hydrocolloids,
Год журнала:
2024,
Номер
unknown, С. 110871 - 110871
Опубликована: Ноя. 1, 2024
Язык: Английский
Biochemical Impact of Nickel‐Induced Metabolic Impairment and the Protective Effects of Resveratrol and Ascorbic Acid
Journal of Food Biochemistry,
Год журнала:
2024,
Номер
2024(1)
Опубликована: Янв. 1, 2024
Nickel
exposure
is
known
to
induce
oxidative
stress
and
inflammation
disrupt
critical
metabolic
pathways,
leading
hepatic
dysfunction
impaired
glucose
regulation.
This
study
aimed
evaluate
the
biochemical
effects
of
nickel‐induced
impairments
in
an
animal
model,
using
a
variety
techniques,
including
ELISA
instrumental
analysis,
with
specific
focus
on
expression
key
genes
involved
insulin
regulation
homeostasis.
The
experiment
included
four
groups:
Control,
Nickel‐exposed,
Nickel‐exposed
standard
treatment
(ascorbic
acid,
AA),
resveratrol
(RSV).
Serum
nickel
levels,
measured
via
ICP‐MS,
showed
significant
increase
exposed
group,
mean
value
125.74
±
6.20
ppb.
analysis
various
biomarkers
demonstrated
that
resulted
hyperglycemia,
elevated
HOMA‐IR,
HbA1c,
DPP‐4,
increased
level
inflammatory
cytokines,
altered
lipid
profiles,
liver
kidney
function.
triggered
inflammation,
disrupted
carbohydrate
metabolism,
induced
stress,
related
endoplasmic
reticulum
(ER)
metabolism.
These
changes
culminated
mitochondrial
dysfunction,
resistance,
as
evidenced
by
reduced
GLUT‐2
GCK—genes
for
uptake
secretion.
Elevated
serum
levels
amino
acids,
such
glutamate
valine,
further
indicated
disruptions
acid
metabolism
stress.
Therapeutic
interventions
AA
RSV
protective
effects:
Both
compounds
mitigated
restored
normal
GCK
GLUT‐2,
improving
sensitivity.
Additionally,
alleviated
suppressing
overexpression
UCP2,
protein
linked
energy
were
also
normalized,
highlighting
their
role
reestablishing
balance.
In
conclusion,
this
highlights
therapeutic
potential
mitigating
disturbances.
findings
emphasize
importance
addressing
disorders
position
promising
candidate
restoring
Further
research
warranted
elucidate
precise
molecular
mechanisms
underlying
effects.
Язык: Английский