Bioengineering, Год журнала: 2025, Номер 12(1), С. 76 - 76
Опубликована: Янв. 15, 2025
Bioprinting, an innovative combination of biotechnology and additive manufacturing, has emerged as a transformative technology in healthcare, enabling the fabrication functional tissues, organs, patient-specific implants. The implementation aforementioned, however, introduces unique intellectual property (IP) challenges that extend beyond conventional biotechnology. study explores three critical areas concern: IP protection for bioprinting hardware bioinks, ownership ethical management digital files derived from biological data, implications commercializing bioprinted tissues organs. Employing multidisciplinary approach, paper analyzes existing frameworks, highlights their limitations when applied to bioprinting, examines dilemmas, such human commodification innovations. Findings suggest current laws inadequately address complexities particularly managing intersection proprietary technologies considerations. underscores need adaptive legal frameworks balance innovation with equitable access sustainability. Recommendations include development tailored policies enhanced international collaboration harmonize protections across jurisdictions. This work aims provide comprehensive foundation stakeholders navigate rapidly evolving landscape IP.
Язык: Английский
Процитировано
4Innovative 3D printing technologies and advanced materials revolutionizing orthopedic surgery: current applications and future directions
Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13
Опубликована: Фев. 11, 2025
Three-dimensional (3D) printing has rapidly become a transformative force in orthopedic surgery, enabling the creation of highly customized and precise medical implants surgical tools. This review aims to provide more systematic comprehensive perspective on emerging 3D technologies—ranging from extrusion-based methods bioink powder bed fusion—and broadening array materials, including bioactive agents cell-laden inks. We highlight how these technologies materials are employed fabricate patient-specific implants, guides, prosthetics, advanced tissue engineering scaffolds, significantly enhancing outcomes patient recovery. Despite notable progress, field faces challenges such as optimizing mechanical properties, ensuring structural integrity, addressing regulatory complexities across different regions, considering environmental impacts cost barriers, especially low-resource settings. Looking ahead, innovations smart functionally graded (FGMs), along with advancements bioprinting, hold promise for overcoming obstacles expanding capabilities orthopedics. underscores pivotal role interdisciplinary collaboration ongoing research harnessing full potential additive manufacturing, ultimately paving way effective, personalized, durable solutions that improve quality life.
Язык: Английский
Процитировано
2Bioink Formulations for 3D Printing of Tissue Scaffolds: A Review of Materials and Printability
The minerals, metals & materials series, Год журнала: 2024, Номер unknown, С. 484 - 499
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
6Three-dimensional printed models can reduce costs and surgical time for complex proximal humeral fractures: preoperative planning, patient satisfaction, and improved resident skills
Journal of Orthopaedics and Traumatology, Год журнала: 2024, Номер 25(1)
Опубликована: Фев. 28, 2024
Abstract Background Proximal humeral fractures (PHFs) are still controversial with regards to treatment and difficult classify. The study’s objective is show that preoperative planning performed while handling a three-dimensional (3D) printed anatomical model of the fracture can ensure better understanding trauma for both surgeons patients. Materials methods Twenty patients (group A, cases) complex PHF were evaluated preoperatively by reproducing life-size, full-touch 3D models. Intraoperative blood loss, radiographic controls, duration surgery, clinical outcomes in group A compared 20 B, controls) who underwent standard evaluation. Additionally, senior residents, as well patients, answered questionnaire evaluate innovative patient compliance. Cost analysis was evaluated. Results radiography controls length operation significantly shorter A. There no differences or loss. Patients claim suffered proposed treatment. Surgeons assert definitive models has had good impact. development this tool been received residents. surgery reduced 15%, resulting savings about EUR 400 each intervention. Conclusions Fewer intraoperative checks, surgeries, compliance reduce radiation exposure healthcare staff, enhance surgical reducing expenses, lower risk medicolegal claims. Level evidence I, prospective randomized case–control study.
Язык: Английский
Процитировано
6BIOIMPRESSÃO 3D DE TECIDOS E ÓRGÃOS: FUTURO DA RECONSTRUÇÃO CIRÚRGICA
Revista Contemporânea, Год журнала: 2025, Номер 5(2), С. e7503 - e7503
Опубликована: Фев. 18, 2025
A medicina moderna está passando por uma transformação significativa com o advento da bioimpressão tridimensional (3D), tecnologia inovadora que integra biologia, engenharia e ciência dos materiais para desenvolver tecidos órgãos funcionais. Essa inovação apresenta um potencial revolucionário a reconstrução cirúrgica regenerativa, oferecendo soluções personalizadas superam as limitações tratamentos convencionais, como escassez de doadores, rejeição imunológica falta compatibilidade funcional. Este estudo tem objetivo realizar revisão narrativa literatura sobre 3D órgãos, explorando suas aplicações na cirúrgica, seus avanços recentes desafios futuros. metodologia adotada consiste síntese das descobertas científicas mais analisar impacto dessa prática clínica. Os resultados indicam bioimpressos, pele, cartilagem ossos, já estão sendo utilizados em contextos experimentais clínicos, demonstrando eficácia redução complicações, melhora recuperação pacientes otimização recursos saúde. Além disso, pesquisas andamento complexos, coração fígado, apontam possíveis transplantação órgãos. No entanto, tecnológicos regulatórios significativos ainda persistem, incluindo vascularização, biomateriais padronização protocolos impressão. O ressalta importância colaboração interdisciplinar, considerações éticas do desenvolvimento políticas regulatórias garantir implementação segura equitativa Por fim, redefinir melhorar os desfechos clínicos contribuir abordagem sustentável personalizada medicina.
Процитировано
0Regenerative Medicine in Plastic Surgery: The Role of Stem Cells and Bioprinting
Regenesis repair rehabilitation., Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0The rise of 3D bioprinting: from organs to personalized medicine
Patient-Oriented Medicine and Pharmacy, Год журнала: 2025, Номер unknown
Опубликована: Март 7, 2025
Bioprinting has emerged as a groundbreaking technology in the realms of organ transplantation and regenerative medicine, addressing critical challenges such shortages tissue repair. This review explores technological advancements innovations bioprinting, highlighting state-of-the-art techniques, bioinks, applications engineering. Key milestones printing functional tissues, including vascularized transplantable prototypes, are discussed alongside role bioprinting personalized where patient-oriented models revolutionizing drug testing therapeutic strategies. Furthermore, this article examines ethical considerations associated with offering insights into its future potential to transform global healthcare.
Язык: Английский
Процитировано
0Identifying and Visualizing Highly Influential and Cited Papers in 3D Bioprinting: A Bibliometric Analysis
Journal of Hospital Librarianship, Год журнала: 2025, Номер unknown, С. 1 - 18
Опубликована: Март 19, 2025
Язык: Английский
Процитировано
0Recent Trends and Future Directions in 3D Printing of Biocompatible Polymers
Journal of Manufacturing and Materials Processing, Год журнала: 2025, Номер 9(4), С. 129 - 129
Опубликована: Апрель 14, 2025
Three-dimensional (3D) bioprinting using biocompatible polymers has emerged as a revolutionary technique in tissue engineering and regenerative medicine. These biopolymers mimic the extracellular matrix (ECM) enhance cellular behavior. The current review presents recent advancements additive manufacturing processes including Stereolithography (SLA), Fused Filament Fabrication (FFF), Selective Laser Sintering (SLS), inkjet printing. It also explores fundamentals of 3D printing properties for bioprinting. By mixing biopolymers, enhancing rheological characteristics, adding bioactive components, further have been made organ transplantation, drug development, engineering. As research progresses, potential to fundamentally transform healthcare system is becoming obvious clear. However, therapeutic printed structures hindered by issues such material anisotropy, poor mechanical properties, need more biodegradable architectures. Future should concentrate on optimizing process sophisticated computational techniques, systematically examining characteristics customizing bioinks different cell types, exploring sustainable materials.
Язык: Английский
Процитировано
0Bioprinting in Organ Transplantation: From Experimental Models to Clinical Prospects
Brazilian Journal of Transplantation, Год журнала: 2025, Номер 28(1)
Опубликована: Апрель 25, 2025
Background: Bioprinting has emerged as an innovative technology in organ transplantation and regenerative medicine, aiming to address pressing challenges such the shortage of donor organs need for effective tissue repair. By leveraging advanced 3D printing techniques, bioprinting enables fabrication functional tissues with precise architectural biological properties. Methods: This review provides in-depth analysis latest advancements bioprinting, focusing on cutting-edge development bioinks, their applications engineering. It examines significant breakthroughs creation vascularized transplantable prototypes explores role personalized medicine. Results: The findings highlight transformative impact biomedical field, particularly drug testing, therapeutic modeling, patient-specific treatment strategies. Additionally, key challenges—including technological limitations, ethical concerns, regulatory considerations—are discussed provide a comprehensive understanding field’s progress potential obstacles. Conclusion: holds immense promise revolutionizing global healthcare by offering solutions shortages advancing However, continued research innovation are necessary overcome existing facilitate its clinical translation into mainstream medical practice.
Язык: Английский
Процитировано
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