Phosphoproteomic analysis reveals the mechanisms of human umbilical cord mesenchymal stem cell-derived exosomes attenuate renal aging DOI

Wenzhuo Yu,

Jia Xu, Qiao Han

и другие.

Journal of Proteomics, Год журнала: 2024, Номер 310, С. 105335 - 105335

Опубликована: Окт. 20, 2024

Язык: Английский

Advancements in extracellular vesicles biomanufacturing: a comprehensive overview of large-scale production and clinical research DOI Creative Commons
Ziqian Li, Junyu Yan, Xiang Li

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Фев. 19, 2025

Extracellular vesicles (EVs) are nano-sized, membranous structures secreted by cells into the extracellular space, have attracted considerable attention in field of biosciences for their role intercellular communication various physiological and pathological processes. Their ubiquitous presence bodily fluids cell-specific characteristics make them promising candidates as biomarkers. Additionally, ability to transport biological therapeutics across different barriers specific target underscores significant translational potential diagnostic therapeutic purposes. Significant progress has been achieved translation EVs research clinical applications, however, challenges persist large-scale production EVs, particularly areas scalable manufacturing, efficient isolation methods, drug loading techniques, advanced characterization technology. This review critically examines complex processes involved biogenesis explores recent developments production. By synthesizing knowledge from these fields, this aims provide a holistic perspective on evolving landscape its underscoring both accomplishments obstacles that lie ahead fully realizing biomedicine.

Язык: Английский

Процитировано

1

Extracellular vesicles secreted by leukemic cells as mediators of dysregulated hematopoiesis: acute myeloid leukemia as a case in point DOI

Vishakha Kasherwal,

Vaijayanti Kale, Anuradha Vaidya

и другие.

Expert Review of Hematology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

Acute myeloid leukemia (AML) cells exhibit a profound capacity for resistance to conventional chemotherapeutic agents, posing substantial challenge existing therapeutic paradigms. Interestingly, this happens in the face of luxuriant proliferation leukemic blasts peripheral blood. This paradox concurrent proliferative activity and cellular quiescence underscores complex biological phenomenon that is intricately mediated by AML-derived Extracellular vesicles (EVs). An extensive literature review search was done on Pubmed/Scopus/Web Sciences databases identify studies published between 2013 2024 elucidating demonstrating effect EVs, Microvesicles (MVs) Exosomes (Exos) regulating normal dysregulated bone marrow (BM) niche. The delves into understanding molecular mechanisms underlying dual behavior AML - quiescence, with special focus role EVs their subtypes viz. Exos MVs establishing discrete BM microenvironment subversive chemotherapy. It offers novel perspective intricate interplay microenvironment, implications interventions targeting persistence drug resistance.

Язык: Английский

Процитировано

0

The Genetic and Biological Basis of Pseudoarthrosis in Fractures: Current Understanding and Future Directions DOI Creative Commons

Amalia Kotsifaki,

Georgia Kalouda,

Sousanna Maroulaki

и другие.

Diseases, Год журнала: 2025, Номер 13(3), С. 75 - 75

Опубликована: Март 3, 2025

Pseudoarthrosis—the failure of normal fracture healing—remains a significant orthopedic challenge affecting approximately 10–15% long bone fractures, and is associated with pain, prolonged disability, repeated surgical interventions. Despite extensive research into the pathophysiological mechanisms healing, diagnostic approaches remain reliant on clinical findings radiographic evaluations, little innovation in tools to predict or diagnose non-union. The present review evaluates current understanding genetic biological basis pseudoarthrosis highlights future directions. Recent studies have highlighted potential specific molecules markers serve as predictors unsuccessful healing. Alterations mesenchymal stromal cell (MSC) function, including diminished osteogenic increased cellular senescence, are central pathogenesis. Molecular analyses reveal suppressed morphogenetic protein (BMP) signaling elevated levels its inhibitors, such Noggin Gremlin, which impair regeneration. Genetic uncovered polymorphisms BMP, matrix metalloproteinase (MMP), Wnt pathways, suggesting predisposition Additionally, differences between atrophic hypertrophic pseudoarthrosis, variations vascularity inflammatory responses, emphasize need for targeted management. Emerging biomarkers, circulating microRNAs (miRNAs), cytokine profiles, blood-derived MSCs, other (B7-1 PlGF-1), contribute early detection at-risk patients personalized therapeutic approaches. Advancing our underpinnings essential development innovative strategies.

Язык: Английский

Процитировано

0

Associations of exposure to volatile organic compounds with biological aging: a cross-sectional study DOI Creative Commons
X M Shi,

YiNi Wang,

Fei Yang

и другие.

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 22, 2025

Язык: Английский

Процитировано

0

Phosphoproteomic analysis reveals the mechanisms of human umbilical cord mesenchymal stem cell-derived exosomes attenuate renal aging DOI

Wenzhuo Yu,

Jia Xu, Qiao Han

и другие.

Journal of Proteomics, Год журнала: 2024, Номер 310, С. 105335 - 105335

Опубликована: Окт. 20, 2024

Язык: Английский

Процитировано

2