Docetaxel Micelles: A New Formulation to Diminish Hypersensitivity Reactions DOI Creative Commons

Lanlan Xiang,

Hao Wang,

Jiajie Liu

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 184 - 184

Опубликована: Фев. 2, 2025

Background/Objectives: Docetaxel is a potent anti-cancer agent capable of treating various types cancer. However, it often induces range adverse reactions when used with its standard solubilizer, Tween-80, necessitating allergy prophylaxis dexamethasone prior to administration. To mitigate the risk allergic reactions, nanomicelles garnering significant interest due their enhanced solubility and thermodynamic stability. Methods: In this research, mPEG-PLA-Lys(Fmoc) micellar carrier m = 45 n 10 was engineered encapsulate docetaxel, self-assembly into micelles investigated. Additionally, reaction studies were conducted on animals. Results: The findings indicated that formulation did not cause hemolysis, vascular, or muscle irritation in rabbits, nor elicit an response guinea pigs. Conclusions: These results suggest nanomicelle-encapsulated docetaxel can diminish associated injections, offering novel approach enhance therapeutic utility outstanding drug.

Язык: Английский

Docetaxel Micelles: A New Formulation to Diminish Hypersensitivity Reactions DOI Creative Commons

Lanlan Xiang,

Hao Wang,

Jiajie Liu

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 184 - 184

Опубликована: Фев. 2, 2025

Background/Objectives: Docetaxel is a potent anti-cancer agent capable of treating various types cancer. However, it often induces range adverse reactions when used with its standard solubilizer, Tween-80, necessitating allergy prophylaxis dexamethasone prior to administration. To mitigate the risk allergic reactions, nanomicelles garnering significant interest due their enhanced solubility and thermodynamic stability. Methods: In this research, mPEG-PLA-Lys(Fmoc) micellar carrier m = 45 n 10 was engineered encapsulate docetaxel, self-assembly into micelles investigated. Additionally, reaction studies were conducted on animals. Results: The findings indicated that formulation did not cause hemolysis, vascular, or muscle irritation in rabbits, nor elicit an response guinea pigs. Conclusions: These results suggest nanomicelle-encapsulated docetaxel can diminish associated injections, offering novel approach enhance therapeutic utility outstanding drug.

Язык: Английский

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