Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health

Cells, Год журнала: 2023, Номер 12(1), С. 184 - 184

Опубликована: Янв. 2, 2023

Immune cells and commensal microbes in the human intestine constantly communicate with react to each other a stable environment order maintain healthy immune activities. system-microbiota cross-talk relies on complex network of pathways that sustain balance between tolerance immunogenicity. Probiotic bacteria can interact stimulate intestinal microflora modulate specific functions homeostasis. Growing evidence shows probiotic present important health-promoting immunomodulatory properties. Thus, use probiotics might represent promising approach for improving system So far, few studies have been reported beneficial modulatory effect probiotics. However, many others, which are mainly focused their metabolic/nutritional properties, published. Therefore, mechanisms behind interaction host only partially described. The review aims collect summarize most recent scientific results resulting implications how improve functions. Hence, description currently known is provided.

Язык: Английский

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Targeting gut microbiota and metabolism as the major probiotic mechanism - An evidence-based review

Trends in Food Science & Technology, Год журнала: 2023, Номер 138, С. 178 - 198

Опубликована: Июнь 11, 2023

The human gut hosts complex microbial communities, which are linked to health and disease. microbiota is continuously reshaped by multiple environmental factors, especially diet. Gut dysbiosis may promote various metabolic, neurological, intestinal, cardiovascular diseases, even tumor development. Probiotics have shown promising prophylactic, mitigating, or curative effects when use as nutrient supplements adjunctive therapy. These beneficial and/or symptom alleviation often accompanied microbiome metabolome changes. Differing from other published review articles, here we summarized the latest knowledge of evidence-based health-promoting probiotics scouring literature recent animal probiotic intervention studies. To elucidate mechanisms in enhancing intestinal homeostasis, barrier function, host immunity, through modulating its metabolites. Meanwhile, also discussed challenges data analysis clinical research comparison between laboratories, provides an outlook for future perspectives applications probiotics. achieved modulation. Current discussed. Finally, provided.

Язык: Английский

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Evidences and perspectives of the use of probiotics, prebiotics, synbiotics, and postbiotics as adjuvants for prevention and treatment of COVID-19: A bibliometric analysis and systematic review

Trends in Food Science & Technology, Год журнала: 2022, Номер 120, С. 174 - 192

Опубликована: Янв. 2, 2022

Язык: Английский

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Fermented foods and gastrointestinal health: underlying mechanisms

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2023, Номер 21(4), С. 248 - 266

Опубликована: Дек. 11, 2023

Язык: Английский

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An Overview of the Public Health Challenges in Diagnosing and Controlling Human Foodborne Pathogens

Vaccines, Год журнала: 2023, Номер 11(4), С. 725 - 725

Опубликована: Март 24, 2023

Pathogens found in food are believed to be the leading cause of foodborne illnesses; and they considered a serious problem with global ramifications. During last few decades, lot attention has been paid determining microorganisms that illnesses developing new methods identify them. Foodborne pathogen identification technologies have evolved rapidly over newer focusing on immunoassays, genome-wide approaches, biosensors, mass spectrometry as primary identification. Bacteriophages (phages), probiotics prebiotics were known ability combat bacterial diseases since turn 20th century. A focus phage use was development medical therapies; however, its quickly expanded other applications biotechnology industry. similar argument can made regards safety industry, directly endanger health customers. Recently, bacteriophages, most likely due exhaustion traditional antibiotics. Reviewing variety current quick techniques is purpose this study. Using these techniques, we able pathogenic bacteria, which forms basis for future research advances. review recent studies phages, means combating significant also presented. Furthermore, discussed advantages using phages well challenges face, especially given their prevalent application safety.

Язык: Английский

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Postbiotics: From emerging concept to application

Frontiers in Sustainable Food Systems, Год журнала: 2022, Номер 6

Опубликована: Сен. 21, 2022

The microbiome innovation has resulted in an umbrella term, postbiotics, which refers to non-viable microbial cells, metabolic byproducts and their components released after lysis. Postbiotics, modulate immune response, gene expression, inhibit pathogen binding, maintain intestinal barriers, help controlling carcinogenesis infections. Postbiotics have antimicrobial, antioxidant, immunomodulatory properties with favorable physiological, immunological, neuro-hormonal, regulatory reactions. Consumption of postbiotics relieves symptoms various diseases viral infections such as SARS-CoV-2. can act alternatives for pre-probiotic specially immunosuppressed patients, children premature neonates. are used preserve enhance nutritional food, elimination biofilms skin conditioning cosmetics. numerous advantages over live bacteria no risk bacterial translocation from the gut blood, acquisition antibiotic resistance genes. process extraction, standardization, transport, storage postbiotic is more natural. Bioengineering techniques fermentation technology, high pressure etc., may be synthesis different postbiotics. Safety assessment quality assurance important they induce stomach discomfort, sepsis and/or toxic shock. still infancy compared pre- pro- biotics but future research this field contribute improved physiological functions host health. current review comprehensively summarizes new frontiers

Язык: Английский

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Current understanding of antibiotic-associated dysbiosis and approaches for its management

Therapeutic Advances in Infectious Disease, Год журнала: 2023, Номер 10

Опубликована: Янв. 1, 2023

Increased exposure to antibiotics during early childhood increases the risk of antibiotic-associated dysbiosis, which is associated with reduced diversity gut microbial species and abundance certain taxa, disruption host immunity, emergence antibiotic-resistant microbes. The microbiota immunity in life linked development immune-related metabolic disorders later life. Antibiotic administration populations predisposed such as newborns, obese children, children allergic rhinitis recurrent infections; changes composition diversity; exacerbating dysbiosis resulting negative health outcomes. Antibiotic-associated diarrhea (AAD), Clostridiodes difficile-associated (CDAD), Helicobacter pylori infection are all short-term consequences antibiotic treatment that persist from a few weeks months. Changes microbiota, even 2 years after exposure, obesity, allergies, asthma among long-term consequences. Probiotic bacteria dietary supplements can potentially prevent or reverse dysbiosis. Probiotics have been demonstrated clinical studies help AAD and, lesser extent, CDAD, well improve H eradication rates. In Indian setting, probiotics ( Saccharomyces boulardii Bacillus clausii) shown reduce duration frequency acute children. Antibiotics may exaggerate vulnerable already affected by condition. Therefore, prudent use neonates young critical detrimental effects on health.

Язык: Английский

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Next-Generation Probiotics as Novel Therapeutics for Improving Human Health: Current Trends and Future Perspectives

Microorganisms, Год журнала: 2024, Номер 12(3), С. 430 - 430

Опубликована: Фев. 20, 2024

Next-generation probiotics (NGPs) represent an innovative group of beneficial bacteria that are currently undergoing research and development. NGPs designed not only for conventional use as foods or dietary supplements but also tailored pharmaceutical applications. Research indicates show therapeutic promise in addressing various chronic ailments. Offering multiple advantages over probiotics, present opportunities personalized probiotic therapies, involvement synthetic biology gene editing, participation combination targeted delivery methods, application settings. Our review discusses the potential effect NGPs, covering diverse trajectories including their identification, characterization, delivery. Furthermore, this elucidates influence on critical aspects human health, specifically, gut immune function, broader health outcomes. Mechanistic insights encompass production bioactive compounds, competitive interactions with pathogenic bacteria, modulation cell activity, reinforcement barrier. What is noteworthy current points out prevalent NGP strains sources, providing a highlight comprehensive framework understanding applications future benefits domain advanced therapeutics.

Язык: Английский

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Effects of Probiotics on Gut Microbiota: An Overview

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 6022 - 6022

Опубликована: Май 30, 2024

The role of probiotics in regulating intestinal flora to enhance host immunity has recently received widespread attention. Altering the human gut microbiota may increase predisposition several disease phenotypes such as inflammation and metabolic disorders. converts dietary nutrients into metabolites that serve biologically active molecules modulating regulatory functions host. Probiotics, which are microorganisms, play a versatile restoring composition microbiota, helping improve prevent phenotypes. This comprehensive review provides firsthand information on their influence health, effects diet how alter function along with corresponding building healthy intestine. We also discuss implications some most important diseases. In summary, significant boosting overall immunity, increasing abundance beneficial bacteria, ameliorate symptoms multiple

Язык: Английский

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Natural Ingredients to Improve Immunity

Pharmaceuticals, Год журнала: 2023, Номер 16(4), С. 528 - 528

Опубликована: Апрель 1, 2023

The immune system protects the body from infectious agents such as bacteria, viruses, or fungi. Once encountered with pathogens antigens, innate and adaptive arms of trigger a strong response to eliminate them protect body. Thus, well-balanced immunity is pivotal for maintaining human health, an insufficient level defense leads infections tumors. In contrast, excessive functioning causes development autoimmune diseases allergies. Strong requires adequate nutrition, dietary interventions, sufficient intake certain vitamins (vitamin C, vitamin D, folic acid) minerals (magnesium, zinc, selenium). Therefore, nutritional micronutrient deficiencies lead compromised immunity. Several natural ingredients have shown potent immunomodulatory properties. immune-enhancing properties many plants fungi are due containing bioactive phytoconstituents polyphenols, terpenoids, β-glucans, vitamins, etc. Probiotics prebiotics can be used innovative tools reduce intestinal inflammation downregulate hypersensitivity reactions. Plant sources melatonin, multifunctional molecule proven anti-inflammatory properties, been discovered relatively recently. compounds augment by directly increasing cytotoxic activity killer cells, macrophages, neutrophils. Many prevent cell damage their powerful antimicrobial, antioxidant, present review attempts understand molecular mechanisms underlying some plants, fungi, animals, microorganisms, other sources.

Язык: Английский

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