Mechanism analysis of surface structure-regulated Cu2O in photocatalytic antibacterial process

Journal of Hazardous Materials, Год журнала: 2023, Номер 461, С. 132479 - 132479

Опубликована: Сен. 4, 2023

Язык: Английский

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Multi-species biofilms of environmental microbiota isolated from fruit packing facilities promoted tolerance of Listeria monocytogenes to benzalkonium chloride

Biofilm, Год журнала: 2024, Номер 7, С. 100177 - 100177

Опубликована: Янв. 21, 2024

may survive and persist in food processing environments due to formation of complex multi-species biofilms environmental microbiota that co-exists these environments. This study aimed determine the effect selected on biofilm tolerance

Язык: Английский

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Anti-Biofilm and Antibacterial Activities of Cycas media R. Br Secondary Metabolites: In Silico, In Vitro, and In Vivo Approaches

Antibiotics, Год журнала: 2022, Номер 11(8), С. 993 - 993

Опубликована: Июль 24, 2022

Enterococcus species possess many virulence factors that have an essential role in exacerbating the infections caused by them. The current study aimed to evaluate effect of secondary metabolites ginkgetin (GINK) and sotetsuflavone (SOTE), isolated from Cycas media R. Br dichloromethane fraction, on faecalis (E. faecalis) isolates for first time. antibacterial antivirulence activities compounds were investigated using docking studies vitro determination minimum inhibitory concentrations (MICs). Additionally, flow cytometry scanning electron microscope (SEM) utilized assess SOTE tested bacteria. Moreover, crystal violet assay qRT-PCR used test biofilm-forming ability E. isolates. In addition, a systemic infection model was vivo investigate activity SOTE. We found both GINK showed good affinity five proteins enrolled faecalis, with being highest, suggesting possible mechanisms ligands. exhibited higher than GINK, as values MICs lower those GINK. Thus, we performed assays However, they did not exhibit any significant variations (p > 0.05) membrane depolarization evaluated SEM, distortion deformation treated cells. Regarding its impact biofilm formation, it inhibited isolates, determined qRT-PCR. experiment revealed resulted reduction inflammation liver spleen increase survival rate. also improved liver-function tests decreased tumor necrosis factor-alpha immunostaining markers, interleukins (IL-1β IL-6), ELISA. can conclude could be promising compound should future preclinical clinical studies.

Язык: Английский

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In vitro evaluation of silver-zinc oxide-eugenol nanocomposite for enhanced antimicrobial and wound healing applications in diabetic conditions

Discover Nano, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 23, 2025

Diabetic wounds with chronic infections present a significant challenge, exacerbated by the growing issue of antimicrobial resistance, which often leads to delayed healing and increased morbidity. This study introduces novel silver-zinc oxide-eugenol (Ag+ZnO+EU) nanocomposite, specifically designed enhance activity promote wound healing. The nanocomposite was thoroughly characterized using advanced analytical techniques, confirming its nanoscale structure, stability chemical composition. Ag+ZnO+EU demonstrated potent efficacy against range associated pathogens, including standard clinical isolates Staphylococcus aureus, Pseudomonas aeruginosa Candida albicans. Minimum inhibitory concentrations for were significantly lower than those individual components, highlighting synergistic effect nanocomposite. Time-kill assays revealed rapid microbial eradication, achieving complete sterility within 240-min. Importantly, effectively eliminated persister-like cells, are typically resistant conventional treatments, suggesting potential solution persistent infections. In vitro scratch human keratinocyte cells that accelerated closure, near-complete observed 24-h, indicating enhanced cell migration tissue regeneration. Additionally, showed antidiabetic effects increasing glucose uptake up 97.21% in an assay 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxy-D-glucose, fluorescent analog, applications beyond These findings highlight as promising candidate addressing both resistance impaired diabetic contexts.

Язык: Английский

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Green synthesis of peroxidase mimetic Cobalt ferrite nanoparticles for antioxidant, anti-bacterial and drug delivery studies

Materials Today Chemistry, Год журнала: 2025, Номер 43, С. 102502 - 102502

Опубликована: Янв. 1, 2025

Язык: Английский

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Bactericidal activity of gallic acid against multi-drug resistance Escherichia coli

Microbial Pathogenesis, Год журнала: 2022, Номер 173, С. 105824 - 105824

Опубликована: Окт. 13, 2022

Язык: Английский

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Isolation, characterization, identification, genomics and analyses of bioaccumulation and biosorption potential of two arsenic-resistant bacteria obtained from natural environments

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Март 8, 2024

Abstract Arsenic (As) is a significant contaminant whose unrestrained entrance into different ecosystems has created global concern. At the cellular level, As forms unsteady intermediates with genetic materials and perturbs metabolic processes proper folding of proteins. This study was first in this region to explore, isolate, screen systematically, intensively characterize potent As-tolerant bacterial strains from natural environments near Raiganj town Uttar Dinajpur, West Bengal. In study, two Gram-negative high tolerance poisonous form As, i.e., As(III) As(V), were obtained. Both isolates identified using biochemical tests 16S rRNA gene sequencing. These bacteria oxidized toxic less As(V) depicted towards other heavy metals. Comparative profiling control As-exposed conditions through Fourier-transform infrared spectroscopy showed adjustments cope toxicity. The metal removal efficiency at pH that one isolates, KG1D, could remove efficiently irrespective changes media pH. contrast, by PF14 largely pH-dependent. cell mass both also found favourably adsorb As(III). Whole genome sequence analysis presence arsRBC genes arsenic operon conferring resistance As. Owing their oxidizing potential, bioaccumulation, metals, these be used bioremediate reclaim As-contaminated sites.

Язык: Английский

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Antibacterial and antibiofilm activities of selenium nanoparticles-antibiotic conjugates against anti-multidrug-resistant bacteria

International Journal of Pharmaceutics, Год журнала: 2024, Номер 658, С. 124214 - 124214

Опубликована: Май 8, 2024

Язык: Английский

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Unveiling the structural aspects of novel azo-dyes with promising anti-virulence activity against MRSA: a deep dive into the spectroscopy via integrated experimental and computational approaches

RSC Advances, Год журнала: 2025, Номер 15(3), С. 1665 - 1679

Опубликована: Янв. 1, 2025

A novel series of azo dyes was successfully synthesized by combining amino benzoic acid and phenol on the same molecular framework via linkage.

Язык: Английский

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Cynometra cauliflora essential oils loaded-chitosan nanoparticles: Evaluations of their antioxidant, antimicrobial and cytotoxic activities

International Journal of Biological Macromolecules, Год журнала: 2022, Номер 210, С. 742 - 751

Опубликована: Май 2, 2022

Язык: Английский

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