Identification and characterization of host miRNAs that target the mouse mammary tumour virus (MMTV) genome DOI Creative Commons
Bushra Gull, Waqar Ahmad, Jasmin Baby

и другие.

Open Biology, Год журнала: 2024, Номер 14(12)

Опубликована: Дек. 1, 2024

The intricate interplay between viruses and hosts involves microRNAs (miRNAs) to regulate gene expression by targeting cellular/viral messenger RNAs (mRNAs). Mouse mammary tumour virus (MMTV), the aetiological agent of breast cancer leukaemia/lymphomas in mice, provides an ideal model explore how viral host miRNAs interact modulate replication tumorigenesis. We previously reported dysregulation MMTV-infected glands MMTV-induced tumours, suggesting a direct interaction MMTV miRNAs. To this further, we systematically examined all potential interactions genome using advanced prediction tools. Leveraging miRNA sequencing data from MMTV-expressing cells, identified dysregulated capable MMTV. Docking analysis validated three with genome, followed confirmation RNA immunoprecipitation assays. further targets these mRNA cells. These findings should enhance our understanding replicates interacts induce important for research. Given MMTV's zoonosis association human cancer/lymphomas, if confirmed, work could lead novel miRNA-based antivirals/therapeutics prevent possible transmission associated cancers humans.

Язык: Английский

Expression of microRNAs in the Detection and Therapeutic Roles of Viral Infections: Mechanisms and Applications DOI Creative Commons
Mahla Poudineh, Omeed Darweesh, Mehdi Mokhtari

и другие.

Journal of Virus Eradication, Год журнала: 2025, Номер unknown, С. 100586 - 100586

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Critical Role of Cellular microRNAs in Virus Infection: Decades of Progress DOI Creative Commons
Yaqi Han, Guoqing Zhang,

Xinru Lv

и другие.

Animals and zoonoses., Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Role of infectious agents in Cancer pathogenesis and therapy DOI Creative Commons

Ezichi F. Ofoezie,

C Ogbonna,

Sandra C. Olisakwe

и другие.

The Microbe, Год журнала: 2025, Номер unknown, С. 100284 - 100284

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
The miRNomics of antiretroviral therapy-induced obesity DOI Creative Commons

Niska Majumdar,

Bishwa Raj Pokharel,

Anne E. Dickerson

и другие.

Functional & Integrative Genomics, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 5, 2025

Язык: Английский

Процитировано

0
miRNA-Mediated Mechanisms in the Generation of Effective and Safe Oncolytic Viruses DOI Creative Commons

Мария Сергеевна Торопко,

Sergey Chuvpilo,

Alexander Karabelsky

и другие.

Pharmaceutics, Год журнала: 2024, Номер 16(8), С. 986 - 986

Опубликована: Июль 25, 2024

MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by inhibiting the translation of target transcripts. The profiles miRNAs vary in different tissues and change with development diseases, including cancer. This feature has begun to be used for modification oncolytic viruses (OVs) order increase their selectivity efficacy. OVs represent a relatively new class anticancer drugs; they designed replicate cancer tumors destroy them. These can natural within tumor cells, or recombinant created laboratories. There some concerns regarding OVs’ toxicity, due ability partially healthy tissues. In addition, lytic immunological responses upon OV therapy not always sufficient, so various editing methods used. review discusses latest results preclinical clinical studies OVs, modifications which associated miRNA-mediated mechanism silencing.

Язык: Английский

Процитировано

3
Oncoviral Infections and Small Extracellular Vesicles DOI Creative Commons

Łukasz Ważny,

Theresa L. Whiteside, Monika Pietrowska

и другие.

Viruses, Год журнала: 2024, Номер 16(8), С. 1291 - 1291

Опубликована: Авг. 13, 2024

Small extracellular vesicles (sEV) are small membrane-bound nanovesicles with a size range below 200 nm that released by all types of cells. sEV carry diverse cargo proteins, lipids, glycans, and nucleic acids mimic the content producer mediate intercellular communication play key role in broad variety physiological pathological conditions. Recently, numerous reports have emerged examining viral infections. A significant number similarities biogenesis pathways replication cycles viruses suggest might influence course infections ways. Besides directly modulating virus propagation transporting (complete virions, RNA, DNA), can also modify host antiviral response increase susceptibility cells to infection. The network mutual interactions is particularly complex case oncogenic viruses, deserving special consideration because its significance cancer progression. This review summarizes current knowledge between focusing on abilities modulate carcinogenic properties oncoviruses.

Язык: Английский

Процитировано

2
Computational Screening to Predict MicroRNA Targets in the Flavivirus 3′ UTR Genome: An Approach for Antiviral Development DOI Open Access
Rodolfo Gamaliel Avila‐Bonilla, Juan Santiago Salas-Benito

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(18), С. 10135 - 10135

Опубликована: Сен. 21, 2024

MicroRNAs (miRNAs) are molecules that influence messenger RNA (mRNA) expression levels by binding to the 3′ untranslated region (3′ UTR) of target genes. Host miRNAs can flavivirus replication, either inducing changes in host transcriptome or directly viral genomes. The UTR genome is a conserved crucial for replication. Cells might exploit this well-preserved generating interact with it, ultimately impacting Despite significant efforts identify capable arresting potential all these still poorly characterised. In context, bioinformatic tools have been proposed as fundamental part accelerating discovery interactions between and study, we performed computational analysis reveal from human mosquito species bind flaviviruses. humans, miR-6842 miR-661 were found, while mosquitoes, miR-9-C, miR-2945-5p, miR-11924, miR-282-5p, miR-79 identified. These findings open new avenues studying antivirals against infections.

Язык: Английский

Процитировано

1
MiR-192 and miR-731 synergically inhibit RGNNV infection by targeting ULK1-mediated autophagy in sea perch (Lateolabrax japonicus) DOI
Hongbo Pan, Wanwan Zhang,

Ziling Qin

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 136748 - 136748

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

1
Avian Models for Human Carcinogenesis—Recent Findings from Molecular and Clinical Research DOI Creative Commons

Julia Niebora,

Krzysztof Data, Dominika Domagała

и другие.

Cells, Год журнала: 2024, Номер 13(21), С. 1797 - 1797

Опубликована: Окт. 30, 2024

Birds, especially the chick and hen, have been important biomedical research models for centuries due to accessibility of avian embryo early discovery viruses. Comprehension tumor virology was a milestone in basic cancer research, as that non-viral genesis, it enabled oncogenes. Furthermore, studies on viruses provided initial insights into Kaposi's sarcoma EBV-induced diseases. However, role birds human carcinogenesis extends beyond realm research. Utilization CAM, chorioallantoic membrane, an easily accessible extraembryonic tissue with rich vasculature, has tumor-induced angiogenesis metastasis efficient screening potential anti-cancer compounds. Also, alone is effective preclinical vivo patient-derived xenograft model, which development personalized therapies. adult may also closely resemble oncogenesis, evidenced by laying only animal model spontaneous form ovarian cancer. Avian create interesting alternative compared mammalian models, enabling creation relatively cost-effective easy-to-maintain platform address key questions biology.

Язык: Английский

Процитировано

1
Dengue virus NS1 hits hard at the barrier integrity of human cerebral microvascular endothelial cells via cellular microRNA dysregulations DOI

Apoorva,

Atul Kumar, Sunit K. Singh

и другие.

Tissue Barriers, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 7, 2024

Dengue virus (DENV) infections are commonly reported in the tropical and subtropical regions of world. DENV is to exploit various strategies cross blood-brain barrier. The NS1 protein plays an important role viral neuropathogenesis, resulting endothelial hyperpermeability cytokine-induced vascular leak. miRNAs short non-coding RNAs that play post-transcriptional gene regulations. However, no comprehensive information about involvement DENV-NS1-mediated neuropathogenesis has been explored date. We observed DENV-NS1 significantly alters cellular miRNome human cerebral microvascular cells a bystander fashion. Subsequent target prediction pathway enrichment analysis indicated these microRNAs their corresponding genes involved pathways associated with barrier dysfunction such as "Adherens junction" "Tight junction". Additionally, several miRNA-mRNA pairs were also found be signaling related cytokine production, for instance, "Jak-STAT pathway", "Chemokine "IL-17 "NF-κB "Viral interaction receptor". dysregulated production inflammatory cytokines compromise BBB permeability. This study first report demonstrate miRNA perturbations crucial compromising integrity. It offers insights into potential therapeutic targets mitigate DENV-NS1-induced permeability inflammation.

Язык: Английский

Процитировано

1