Frontiers in Cellular and Infection Microbiology,
Год журнала:
2022,
Номер
11
Опубликована: Фев. 8, 2022
The
diabetic
autonomic
neuropathy
is
one
of
the
most
common
complications
in
type
2
diabetes
mellitus
(T2DM),
especially
gastrointestinal
(GAN),
which
occurs
up
to
75%
patients.
study
aimed
investigate
gut
microbiota
composition,
structure,
and
function
T2DM
patients
with
GAN
(T2DM_GAN)
set
a
link
between
clinical
characteristics
patients.DNA
was
extracted
from
fecal
samples
three
groups
using
kit
method:
healthy
volunteers
(n
=
19),
76),
T2DM_GAN
27).
Sequencing
16S
ribosomal
DNA
performed
MiSeq
platform.According
data,
higher
age,
lower
triglyceride,
body
mass
index
were
main
features
T2DM_GAN.
analysis
showed
that
Bacteroidetes,
Firmicutes,
Proteobacteria
constituted
dominant
phyla
individuals.
In
addition,
structure
clearly
different
characterized
by
Fusobacteria,
Fusobacteriia,
Fusobacteriales,
Fusobacteriaceae,
Fusobacterium,
Lachnoclostridium,
Fusobacterium_mortiferum.
Those
may
be
involved
carotenoid
flavonoid
biosyntheses.
Relatively,
Gammaproteobacteria,
Enterobacteriales,
Enterobacteriaceae,
Escherichia-Shigella,
Megasphaera,
Escherichia_coli,
Megasphaera_elsdenii
characteristic
bacterial
invasion
epithelial
cells
pathogenic
Escherichia
coli
infection.GAN
exacerbated
dysbiosis
adult
T2DM.
findings
indicated
Fusobacteria
class
Gammaproteobacteria
closely
related
occurrence
Especially
latter
promote
Biomedicines,
Год журнала:
2021,
Номер
9(8), С. 870 - 870
Опубликована: Июль 23, 2021
Gastric
cancer
is
considered
one
of
the
most
common
causes
cancer-related
death
worldwide
and,
thus,
a
major
health
problem.
A
variety
environmental
factors
including
physical
and
chemical
noxae,
as
well
pathogen
infections
could
contribute
to
development
gastric
cancer.
The
transcription
factor
nuclear
kappa
B
(NF-κB)
its
dysregulation
has
impact
on
carcinogenesis
due
regulation
cytokines/chemokines,
growth
factors,
anti-apoptotic
cell
cycle
regulators,
metalloproteinases.
Changes
in
NF-κB
signaling
are
directed
by
genetic
alterations
themselves,
but
also
molecules.
actively
participates
crosstalk
cells
tumor
micromilieu
with
divergent
effects
heterogeneous
immune
populations.
Thus,
benefits/consequences
therapeutic
targeting
have
be
carefully
evaluated.
In
this
review,
we
address
recent
knowledge
about
mechanisms
consequences
therapy.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2022,
Номер
11
Опубликована: Фев. 8, 2022
The
diabetic
autonomic
neuropathy
is
one
of
the
most
common
complications
in
type
2
diabetes
mellitus
(T2DM),
especially
gastrointestinal
(GAN),
which
occurs
up
to
75%
patients.
study
aimed
investigate
gut
microbiota
composition,
structure,
and
function
T2DM
patients
with
GAN
(T2DM_GAN)
set
a
link
between
clinical
characteristics
patients.DNA
was
extracted
from
fecal
samples
three
groups
using
kit
method:
healthy
volunteers
(n
=
19),
76),
T2DM_GAN
27).
Sequencing
16S
ribosomal
DNA
performed
MiSeq
platform.According
data,
higher
age,
lower
triglyceride,
body
mass
index
were
main
features
T2DM_GAN.
analysis
showed
that
Bacteroidetes,
Firmicutes,
Proteobacteria
constituted
dominant
phyla
individuals.
In
addition,
structure
clearly
different
characterized
by
Fusobacteria,
Fusobacteriia,
Fusobacteriales,
Fusobacteriaceae,
Fusobacterium,
Lachnoclostridium,
Fusobacterium_mortiferum.
Those
may
be
involved
carotenoid
flavonoid
biosyntheses.
Relatively,
Gammaproteobacteria,
Enterobacteriales,
Enterobacteriaceae,
Escherichia-Shigella,
Megasphaera,
Escherichia_coli,
Megasphaera_elsdenii
characteristic
bacterial
invasion
epithelial
cells
pathogenic
Escherichia
coli
infection.GAN
exacerbated
dysbiosis
adult
T2DM.
findings
indicated
Fusobacteria
class
Gammaproteobacteria
closely
related
occurrence
Especially
latter
promote
