Cells,
Год журнала:
2022,
Номер
11(13), С. 2040 - 2040
Опубликована: Июнь 27, 2022
Ferroptosis,
which
has
been
widely
associated
with
many
diseases,
is
an
iron-dependent
regulated
cell
death
characterized
by
intracellular
lipid
peroxide
accumulation.
It
exhibits
morphological,
biochemical,
and
genetic
characteristics
that
are
unique
in
comparison
to
other
types
of
death.
The
course
ferroptosis
can
be
accurately
the
metabolism
iron,
lipids,
amino
acids,
various
signal
pathways.
In
this
review,
we
summarize
basic
ferroptosis,
its
regulation,
as
well
relationship
between
chronic
diseases
such
cancer,
nervous
system
metabolic
inflammatory
bowel
diseases.
Finally,
describe
regulatory
effects
food-borne
active
ingredients
on
ferroptosis.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Март 4, 2024
Abstract
Arterial
occlusion-induced
ischemic
stroke
(IS)
is
a
highly
frequent
subtype.
Nuclear
factor
erythroid
2-related
2
(NRF2)
transcription
that
modulates
antioxidant
genes.
Its
role
in
IS
still
unelucidated.
The
current
study
focused
on
constructing
transient
middle
cerebral
artery
occlusion
(tMCAO)
model
for
investigating
the
NRF2-related
mechanism
underlying
ischemia/reperfusion
(I/R)
injury.
Each
male
C57BL/6
mouse
was
injected
with/with
no
specific
NRF2
activator
post-tMCAO.
Changes
blood–brain
barrier
(BBB)-associated
molecule
levels
were
analyzed
using
western-blotting,
PCR,
immunohistochemistry,
and
immunofluorescence
analysis.
within
I/R
decreased
at
24-h
post-ischemia.
activation
improved
brain
edema,
infarct
volume,
neurological
deficits
after
MCAO/R.
Similarly,
sulforaphane
(SFN)
prevented
down-regulated
tight
junction
proteins
occludin
zonula
occludens
1
(ZO-1)
reduced
up-regulated
aquaporin
4
(AQP4)
matrix
metalloproteinase
9
(MMP9)
tMCAO.
Collectively,
exerted
critical
effect
preserving
BBB
integrity
modulating
ferroptosis
inflammation.
Because
related
to
injury
regulation
following
I/R,
this
provides
potential
therapeutic
target
throws
light
clinically
treating
IS.
Frontiers in Cell and Developmental Biology,
Год журнала:
2021,
Номер
9
Опубликована: Авг. 10, 2021
Ischemia-reperfusion
(I/R)
injury
is
a
major
cause
of
cell
death
and
organ
damage
in
numerous
pathologies,
including
myocardial
infarction,
stroke,
acute
kidney
injury.
Current
treatment
methods
for
I/R
are
limited.
Ferroptosis,
which
newly
uncovered
type
regulated
characterized
by
iron
overload
lipid
peroxidation
accumulation,
has
been
investigated
various
diseases.
There
increasing
evidence
close
association
between
ferroptosis
injury,
with
frequently
identified
as
new
therapeutic
target
the
management
This
review
summarizes
current
status
discusses
its
relationship
well
potential
strategies
targeting
it.
Food & Function,
Год журнала:
2021,
Номер
12(20), С. 9583 - 9606
Опубликована: Янв. 1, 2021
Ferroptosis
is
a
recently
defined
type
of
regulated
cell
death
caused
by
an
excess
iron-dependent
accumulation
lipid
peroxides
and
morphologically
biochemically
distinct
from
other
types
death.
Notably,
Nrf2
identified
to
exquisitely
modulate
ferroptosis
due
its
ability
target
host
cascade
genes,
which
places
in
the
pivotal
position
ferroptosis.
This
paper
reviews
regulation
effect
on
ferroptosis,
different
activation
mechanisms
as
well
relevance
Nrf2-ferroptosis
axis
diseases,
finally
summarizes
foods
with
beneficial
effects
via
pathway
aims
serve
reference
for
follow-up
studies
food
functions
related
Nrf2,
human
health.
Cells,
Год журнала:
2022,
Номер
11(13), С. 2040 - 2040
Опубликована: Июнь 27, 2022
Ferroptosis,
which
has
been
widely
associated
with
many
diseases,
is
an
iron-dependent
regulated
cell
death
characterized
by
intracellular
lipid
peroxide
accumulation.
It
exhibits
morphological,
biochemical,
and
genetic
characteristics
that
are
unique
in
comparison
to
other
types
of
death.
The
course
ferroptosis
can
be
accurately
the
metabolism
iron,
lipids,
amino
acids,
various
signal
pathways.
In
this
review,
we
summarize
basic
ferroptosis,
its
regulation,
as
well
relationship
between
chronic
diseases
such
cancer,
nervous
system
metabolic
inflammatory
bowel
diseases.
Finally,
describe
regulatory
effects
food-borne
active
ingredients
on
ferroptosis.
