International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(21), С. 16009 - 16009
Опубликована: Ноя. 6, 2023
Globins
have
been
studied
as
model
proteins
to
elucidate
the
principles
of
protein
evolution.
This
was
achieved
by
understanding
relationship
between
amino
acid
sequence,
three-dimensional
structure,
physicochemical
properties,
and
physiological
function.
Previous
molecular
phylogenies
chordate
globin
genes
revealed
monophyletic
evolution
urochordate
globins
suggested
convergent
However,
provide
evidence
evolution,
it
is
necessary
determine
functional
similarities
vertebrates
globins.
In
this
study,
we
determined
expression
patterns
Ciona
using
real-time
RT-PCR.
Two
(Gb-1
Gb-2)
were
predominantly
expressed
in
branchial
sac,
heart,
hemocytes
induced
under
hypoxia.
Combined
with
sequence
analysis,
our
findings
suggest
that
Gb-1/-2
correspond
vertebrate
hemoglobin-α/-β.
did
not
find
a
robust
similarity
Gb-3,
Gb-4,
These
results
that,
even
though
obtained
their
unique
functions
differently
from
globins,
two
them
shared
some
features
functions.
Our
offer
good
example
for
mechanisms
underlying
gene
co-option
convergence,
which
could
lead
evolutionary
innovations.
Medical Gas Research,
Год журнала:
2024,
Номер
15(1), С. 58 - 72
Опубликована: Апрель 21, 2024
Fibromyalgia,
characterized
as
a
complex
chronic
pain
syndrome,
presents
with
symptoms
of
pervasive
musculoskeletal
pain,
significant
fatigue,
and
pronounced
sensitivity
at
specific
anatomical
sites.
Despite
extensive
research
efforts,
the
origins
fibromyalgia
remain
enigmatic.
This
narrative
review
explores
intricate
relationship
between
muscle
oxygen
saturation
fibromyalgia,
positing
that
disruptions
in
oxygenation
processes
within
tissues
markedly
influence
symptom
profile
this
disorder.
Muscle
saturation,
crucial
for
function,
has
been
meticulously
investigated
patients
through
non-invasive
techniques
such
near-infrared
spectroscopy
magnetic
resonance
imaging.
The
body
evidence
consistently
indicates
substantial
alterations
utilization
fibers,
manifesting
reduced
efficiency
uptake
during
both
rest
physical
activity.
These
anomalies
play
role
fibromyalgia’s
symptomatology,
especially
terms
severe
potentially
creating
conditions
heighten
accumulate
metabolic
byproducts.
Hypothesized
mechanisms
these
findings
encompass
dysfunctions
microcirculation,
mitochondrial
irregularities,
autonomic
nervous
system
disturbances,
all
meriting
further
research.
Understanding
dynamics
is
paramount
clinical
importance,
offering
potential
tailored
therapeutic
approaches
to
alleviate
improve
quality
life
sufferers.
investigation
not
only
opens
new
avenues
innovative
but
also
fosters
hope
more
effective
treatment
strategies
improved
outcomes
individuals
fibromyalgia.
Biochemical Pharmacology,
Год журнала:
2024,
Номер
227, С. 116407 - 116407
Опубликована: Июль 3, 2024
Healthy
aging
results
in
cardiac
structural
and
electrical
remodeling
that
increase
susceptibility
to
cardiovascular
diseases.
Relaxin
has
shown
broad
cardioprotective
effects
including
anti-fibrotic,
anti-arrhythmic
anti-inflammatory
outcomes
multiple
models.
This
paper
focuses
on
the
of
a
rat
model
aging.
Sustained
atrial
or
ventricular
fibrillation
are
readily
induced
hearts
aged
but
not
young
control
animals.
Treatment
with
suppressed
this
arrhythmogenic
response
by
increasing
conduction
velocity,
decreasing
fibrosis
promoting
substantial
remodeling.
treatment
resulted
significant
levels
of:
Nav1.5,
Cx43,
βcatenin
Wnt1
hearts.
In
isolated
cardiomyocytes,
increased
Nav1.5
expression.
These
were
mimicked
CHIR
99021,
pharmacological
activator
canonical
Wnt
signaling,
blocked
inhibitor
Dickkopf1.
prevented
TGF-β-dependent
differentiation
fibroblasts
into
myofibroblasts
while
expression
Wnt1;
fibroblast
RNASeq
studies
demonstrated
reduced
pro-inflammatory
cytokines
an
α-
β-globin
Relaxin-treated
males.
reduces
arrhythmogenicity
rats
reduction
velocity.
changes
accompanied
tissue
appear
be
mediated
signaling.
also
exerts
anti-oxidant
rodents.
The
mechanisms
which
increases
ligands,
promotes
signaling
reprograms
gene
remain
determined.
Thrombosis Journal,
Год журнала:
2024,
Номер
22(1)
Опубликована: Сен. 3, 2024
Increased
hemoglobin
concentrations
may
increase
the
risk
of
varicose
veins.
However,
underlying
relationship
between
them
was
not
yet
understood.
Mendelian
randomization
(MR)
analysis
performed
to
investigate
causal
effect
mean
corpuscular
concentration
(MCHC,
exposure
factor)
and
veins
(outcome).
Afterward,
sensitivity
used
ensure
reliability
MR
results.
Then
Gene
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
enrichment
analyses
SNPs
were
performed.
A
search
tool
for
recurring
instances
neighbouring
genes
(STRING)
database
construct
a
protein-protein
interaction
(PPI)
network.
Therefore,
inverse-variance
weighted
(IVW)
results
showed
there
existed
MCHC
(p
=
0.0026),
with
serving
as
significant
factor.
(odd
ratio
[OR]
1.2321).
In
addition,
validity
forward
verified
by
analysis.
Further,
PPI
network
92
single-nucleotide
polymorphisms
(SNPs)
which
related
constructed.
And
they
found
be
closely
associated
peroxisome
proliferator-activated
receptor
(PPAR)
signalling
pathway
cellular
response
external
stimulus
we
clarified
that
on
minimal
reverse
analysis,
suggesting
disturbed
This
study
MCHC,
provided
strong
evidence
veins,
new
thought
diagnosis
prevention
in
future.
Srpski medicinski casopis Lekarske komore,
Год журнала:
2024,
Номер
5(2), С. 215 - 227
Опубликована: Янв. 1, 2024
Exercise
significantly
increases
blood
flow
and
perfusion
in
active
muscles
to
enhance
oxygen
nutrient
delivery.
These
enhanced
demands
affect
rheology
red
cell
(RBC)
characteristics,
leading
specific
adaptations.
adaptations
are
influenced
by
exercise
type,
intensity,
frequency,
duration,
individual
characteristics
of
subject
population
(gender,
age,
nutritional
status
etc.).
This
review
aims
comprehensively
summarize
the
different
erythrocytes
short-term
long-term
exercise,
as
well
mechanisms
their
occurrence,
considering
influence
various
factors.
The
results
from
previous
research
indicate
that
regular
enhances
metabolic,
structural,
functional
capabilities
RBCs.
include
improved
energy
balance,
increased
turnover
rate,
membrane
stability,
better
antioxidative
defense.
Despite
potential
risks
such
"sports
anemia",
also
affects
dynamics
hemoglobin
iron
concentrations,
appearance
extracellular
hemoglobin.
Overall
,
literature
highlights
critical
role
maintaining
optimal
erythrocyte
function,
improving
circulation,
overall
health,
offering
therapeutic
benefits.
Through
a
data
on
functions
erythrocytes,
this
paper
can
be
useful
guideline
for
interpretation
clinically
significant
physically
individuals
.
Molecular Genetics & Genomic Medicine,
Год журнала:
2024,
Номер
12(9)
Опубликована: Сен. 1, 2024
ABSTRACT
Background
Haemoglobinopathy
refers
to
a
group
of
common
monogenic
inherited
conditions
associated
with
variations
in
the
haemoglobin
molecule;
however,
there
is
relatively
limited
reporting
on
abnormal
haemoglobinopathy
Chinese
population,
especially
rare
(Hb).
The
aim
this
study
was
explore
clinical
characteristics
supplement
data
for
epidemiological
investigation
Hb
variants
Guangdong
province
China.
Methods
Peripheral
blood
collected
from
five
patients
(including
family)
Complete
count,
electrophoresis,
High‐performance
liquid
chromatography
analysis
and
degenerative
globin
body
testing.
were
further
analysed
by
PCR
DNA
sequencing.
Results
research
subjects
diagnosed
different
types
Hb.
routine
Fukuyama
(HBB:c.232C>T)
individual
showed
microcytic
hypochromic
anaemia,
lower
level
(64
g/L),
mean
corpuscular
volume
(MCV)
71.5
fL
(MCH)
21.5
pg.
Individuals
Port
Phillip
(HBA2:c.275T>C)
exhibit
MCH
that
slightly
below
average,
at
26.4
Saint
Etienne
(HBB:c.279C>G)
macrocytic
proband
had
low
(116
MCV
102.2
29.4
Conclusion
We
confirmed
presence
China
first
time.
Three
phenotype
one
patient
included.
Our
enriches
gene
mutation
map
improves
detection
system
population
prevention
eugenics.
Biomolecules,
Год журнала:
2023,
Номер
13(3), С. 433 - 433
Опубликована: Фев. 24, 2023
The
seahorse
is
a
marine
teleost
fish
member
of
the
Syngnathidae
family
that
displays
complex
variety
morphological
and
reproductive
behavior
innovations
has
been
recognized
for
its
medicinal
importance.
In
Brazilian
ichthyofauna,
Hippocampus
reidi
among
three
species
most
used
by
population
in
traditional
medicine.
this
study,
protocol
was
performed
based
on
fast
heat
inactivation
proteases
plus
liquid
chromatography
coupled
to
mass
spectrometry
identify
native
peptides
gills
H.
reidi.
MS/MS
spectra
obtained
from
allowed
identification
1080
peptides,
which
1013
were
present
all
samples
67
peptide
sequences
identified
an
additional
LC-MS/MS
run
alkylated
reduced
pool
samples.
majority
fragments
internal
region
amino
acid
sequence
precursor
proteins
(67%),
N-
C-terminal
represented
18%
15%,
respectively.
Many
presented
ribosomal
proteins,
histones
hemoglobin
as
proteins.
addition,
moronecidin-like
protein,
described
with
antimicrobial
activity,
found
gill
may
reveal
new
bioactive
peptides.
BIO Web of Conferences,
Год журнала:
2023,
Номер
59, С. 02018 - 02018
Опубликована: Янв. 1, 2023
More
than
60%
of
the
world’s
countries
do
not
have
enough
blood.
According
to
analysis
report
blood
donors
recorded
in
2021
annual
Taiwan
Blood
Service
Foundation.
Taiwan’s
also
hemoglobin
disqualification
issues,
with
5.5%
them
failing
physical
examinations
before
donation.
The
research
method
is
a
systematic
review
and
comprehensive
literature.
Meta-search
has
shown
that
long-term
are
faced
iron
deficiency.
Moderate
intake
by
longterm
can
improve
impact
on
ferritin.
Significantly
delayed
donation
phenomenon
donors.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(21), С. 16009 - 16009
Опубликована: Ноя. 6, 2023
Globins
have
been
studied
as
model
proteins
to
elucidate
the
principles
of
protein
evolution.
This
was
achieved
by
understanding
relationship
between
amino
acid
sequence,
three-dimensional
structure,
physicochemical
properties,
and
physiological
function.
Previous
molecular
phylogenies
chordate
globin
genes
revealed
monophyletic
evolution
urochordate
globins
suggested
convergent
However,
provide
evidence
evolution,
it
is
necessary
determine
functional
similarities
vertebrates
globins.
In
this
study,
we
determined
expression
patterns
Ciona
using
real-time
RT-PCR.
Two
(Gb-1
Gb-2)
were
predominantly
expressed
in
branchial
sac,
heart,
hemocytes
induced
under
hypoxia.
Combined
with
sequence
analysis,
our
findings
suggest
that
Gb-1/-2
correspond
vertebrate
hemoglobin-α/-β.
did
not
find
a
robust
similarity
Gb-3,
Gb-4,
These
results
that,
even
though
obtained
their
unique
functions
differently
from
globins,
two
them
shared
some
features
functions.
Our
offer
good
example
for
mechanisms
underlying
gene
co-option
convergence,
which
could
lead
evolutionary
innovations.
