Trained innate immunity as a potential link between preeclampsia and future cardiovascular disease DOI Creative Commons
Ivo Carrasco‐Wong, J. Sánchez, Jaime Gutiérrez

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Дек. 16, 2024

Preeclampsia (PE) is a complex pregnancy syndrome characterized by hypertension with or without proteinuria, affecting 2–6% of pregnancies globally. PE excessive release damage-associated molecular patterns (DAMPs) into the maternal circulation. This DAMP-rich milieu acts on innate immune cells, inducing proinflammatory state elevated cytokines such as IL-1β and IL-18. in mother placenta results endothelial dysfunction strongly associated cardiovascular disorders. While immediate fetal risks are well-documented, accumulating evidence indicates that also confers long-term to mother, including hypertension, coronary heart disease, stroke, failure. The underlying mechanisms connecting these chronic conditions remain unclear. article explores potential role trained immunity (TRIM) mechanistic link between increased risk. We propose persistent exposure DAMPs during may epigenetically reprogram cells their progenitors, leading TRIM. reprogramming enhances inflammatory response subsequent stimuli, potentially contributing inflammation predispose women diseases later life. Understanding TRIM could provide novel insights pathophysiology PE-related complications identify targets for therapeutic intervention. Further research warranted investigate epigenetic metabolic alterations induced determine how changes influence health.

Язык: Английский

Oxidative Stress, Lipid Peroxidation and Ferroptosis Are Major Pathophysiological Signatures in the Placental Tissue of Women with Late-Onset Preeclampsia DOI Creative Commons
Miguel Á. Ortega,

Luis M. García-Puente,

Oscar Fraile‐Martínez

и другие.

Antioxidants, Год журнала: 2024, Номер 13(5), С. 591 - 591

Опубликована: Май 11, 2024

Preeclampsia, a serious and potentially life-threatening medical complication occurring during pregnancy, is characterized by hypertension often accompanied proteinuria multiorgan dysfunction. It classified into two subtypes based on the timing of diagnosis: early-onset (EO-PE) late-onset preeclampsia (LO-PE). Despite being less severe exhibiting distinct pathophysiological characteristics, LO-PE more prevalent than EO-PE, although both conditions have significant impact placental health. Previous research indicates that different events within placenta may contribute to development across multiple pathways. In our experimental study, we investigated markers oxidative stress, ferroptosis, lipid peroxidation pathways in tissue samples obtained from women with (n = 68) compared healthy control pregnant (HC, n 43). Through comprehensive analysis, observed an upregulation specific molecules associated these pathways, including NADPH oxidase 1 (NOX-1), 2 (NOX-2), transferrin receptor protein (TFRC), arachidonate 5-lipoxygenase (ALOX-5), acyl-CoA synthetase long-chain family member 4 (ACSL-4), glutathione peroxidase (GPX4) malondialdehyde (MDA) LO-PE. Furthermore, increased ferric deposition (Fe3+) was stained Perls’ Prussian blue. The assessment involved gene expression analyses conducted through RT-qPCR experiments immunohistochemistry assays. Our findings underscore heightened activation inflammatory HC, highlighting pathological mechanisms underlying this pregnancy disorder.

Язык: Английский

Процитировано

9
Metformin inhibits activation of NLRP3 inflammasome and inflammatory response in preeclamptic rats DOI Creative Commons

Ran Jia,

Huijing Ma,

Huiniu Hao

и другие.

Gene, Год журнала: 2024, Номер 919, С. 148509 - 148509

Опубликована: Апрель 25, 2024

It is widely acknowledged that Metformin (MET), an established medication for managing type 2 diabetes, possesses diverse pharmacological effects. This study aims to investigate the protective effects of MET against Nω-Nitro-L-arginine methyl ester (L-NAME)-induced preeclampsia (PE).

Язык: Английский

Процитировано

4
Revealing the dance of NLRP3: spatiotemporal patterns in inflammasome activation DOI Open Access
Lee Spector, Naeha Subramanian

Immunometabolism, Год журнала: 2025, Номер 7(1), С. e00053 - e00053

Опубликована: Янв. 1, 2025

The nucleotide-binding domain, leucine-rich repeat, and pyrin domain containing-protein 3 (NLRP3) inflammasome is a multiprotein complex that plays critical role in the innate immune response to both infections sterile stressors. Dysregulated NLRP3 activation has been implicated variety of autoimmune inflammatory diseases, including cryopyrin-associated periodic fever syndromes, diabetes, atherosclerosis, Alzheimer’s disease, bowel cancer. Consequently, fine-tuning activity holds significant therapeutic potential. Studies have several organelles, mitochondria, lysosomes, endoplasmic reticulum (ER), Golgi apparatus, endosomes, centrosome, localization assembly. However, reports conflict many factors regulating interactions between subcellular organelles remain unknown. This review synthesizes current understanding spatiotemporal dynamics, focusing on recent literature elucidates roles organelle stress signaling its crosstalk with other pathways converging at these organelles.

Язык: Английский

Процитировано

0
Exploring the Importance of Differential Expression of Autophagy Markers in Term Placentas from Late-Onset Preeclamptic Pregnancies DOI Open Access

Luis M. García-Puente,

Cielo García‐Montero, Oscar Fraile‐Martínez

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2029 - 2029

Опубликована: Фев. 7, 2024

Preeclampsia (PE) is a serious hypertensive disorder affecting 4-5% of pregnancies globally, leading to maternal and perinatal morbidity mortality reducing life expectancy in surviving women post-gestation. Late-onset PE (LO-PE) clinical type diagnosed after 34 weeks gestation, being less severe than the early-onset (EO-PE) variant, although both entities have notable impact on placenta. Despite fact that most studies focused EO-PE, LO-PE does not deserve attention since its prevalence much higher little known about role placenta this pathology. Via RT-qPCR immunohistochemistry methods, we measured gene protein expressions several macroautophagy markers chorionic villi placentas from who underwent (

Язык: Английский

Процитировано

2
Exacerbated Activation of the NLRP3 Inflammasome in the Placentas from Women Who Developed Chronic Venous Disease during Pregnancy DOI Open Access

María Asunción Sánchez-Gil,

Oscar Fraile‐Martínez, Cielo García‐Montero

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(10), С. 5528 - 5528

Опубликована: Май 18, 2024

Chronic venous disease (CVD) comprises a spectrum of morphofunctional disorders affecting the system, approximately 1 in 3 women during gestation. Emerging evidence highlights diverse maternofetal implications stemming from CVD, particularly impacting placenta. While systemic inflammation has been associated with pregnancy-related preliminary findings suggest potential link between this condition and exacerbated placental tissue. Inflammasomes are major orchestrators immune responses different organs systems. Notwithstanding relevance inflammasomes, specifically NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3)- which demonstrated placentas obstetric complications, precise involvement component CVD remains to be explored. This study employs immunohistochemistry real-time PCR (RT-qPCR) examine gene protein expression key components both canonical non-canonical pathways inflammasome (NLRP3, ASC-apoptosis-associated speck-like containing C-terminal caspase recruitment domain-caspase 1, 5, 8, interleukin 1β) within tissue affected by CVD. Our reveal substantial upregulation these CVD-affected placentas, indicating pathophysiological role development condition. Subsequent investigations should focus on assessing translational interventions addressing dysregulation patient populations.

Язык: Английский

Процитировано

2
Elevated serum uric acid to creatinine ratio is associated with adverse pregnancy outcomes: a prospective birth cohort study DOI Creative Commons
Enjie Zhang,

Shaofei Su,

Shen Gao

и другие.

International Journal of Medical Sciences, Год журнала: 2024, Номер 21(9), С. 1612 - 1621

Опубликована: Янв. 1, 2024

This study evaluated the association between maternal serum uric acid-to-creatinine ratio (SUA/SCr) in first trimester and adverse neonatal outcomes.

Язык: Английский

Процитировано

2
Placental Tissue Calcification and Its Molecular Pathways in Female Patients with Late-Onset Preeclampsia DOI Creative Commons
Miguel Á. Ortega,

Tatiana Pekarek,

Diego De León-Oliva

и другие.

Biomolecules, Год журнала: 2024, Номер 14(10), С. 1237 - 1237

Опубликована: Сен. 30, 2024

Preeclampsia (PE) is a complex multisystem disease characterized by hypertension of sudden onset (>20 weeks' gestation) coupled with the presence at least one additional complication, such as proteinuria, maternal organ dysfunction, or uteroplacental dysfunction. Hypertensive states during pregnancy carry life-threatening risks for both mother and baby. The pathogenesis PE develops due to dysfunctional placenta aberrant architecture that releases factors contributing endothelial an antiangiogenic state, increased oxidative stress, inflammatory responses. Previous studies have shown correlation between grade 3 placental calcifications elevated risk developing term. However, little known about molecular pathways leading calcification. In this work, we studied gene protein expression c-Jun N-terminal kinase (JNK), Runt-related transcription factor 2 (RUNX2), osteocalcin (OSC), osteopontin (OSP), pigment epithelium-derived (PEDF), MSX-2/HOX8, SOX-9, WNT-1, β-catenin in tissue from women late-onset (LO-PE). addition, employed von Kossa staining detect mineral deposits tissues. Our results show significant increase all these components placentas LO-PE. Therefore, our study suggests LO-PE may be associated activation These could starting point future research describe mechanisms promote calcification development therapeutic strategies directed against it.

Язык: Английский

Процитировано

2
1,25-Dihydroxyvitamin D3 protects against placental inflammation by suppressing NLRP3-mediated IL-1β production via Nrf2 signaling pathway in preeclampsia DOI
Xueqing Liu, Xinyu Zhang, Linlin Ma

и другие.

Metabolism, Год журнала: 2024, Номер 162, С. 156058 - 156058

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

0
Trained innate immunity as a potential link between preeclampsia and future cardiovascular disease DOI Creative Commons
Ivo Carrasco‐Wong, J. Sánchez, Jaime Gutiérrez

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Дек. 16, 2024

Preeclampsia (PE) is a complex pregnancy syndrome characterized by hypertension with or without proteinuria, affecting 2–6% of pregnancies globally. PE excessive release damage-associated molecular patterns (DAMPs) into the maternal circulation. This DAMP-rich milieu acts on innate immune cells, inducing proinflammatory state elevated cytokines such as IL-1β and IL-18. in mother placenta results endothelial dysfunction strongly associated cardiovascular disorders. While immediate fetal risks are well-documented, accumulating evidence indicates that also confers long-term to mother, including hypertension, coronary heart disease, stroke, failure. The underlying mechanisms connecting these chronic conditions remain unclear. article explores potential role trained immunity (TRIM) mechanistic link between increased risk. We propose persistent exposure DAMPs during may epigenetically reprogram cells their progenitors, leading TRIM. reprogramming enhances inflammatory response subsequent stimuli, potentially contributing inflammation predispose women diseases later life. Understanding TRIM could provide novel insights pathophysiology PE-related complications identify targets for therapeutic intervention. Further research warranted investigate epigenetic metabolic alterations induced determine how changes influence health.

Язык: Английский

Процитировано

0