The interplay of exercise and green tea: a new road in cancer therapy
Cancer Cell International,
Год журнала:
2025,
Номер
25(1)
Опубликована: Янв. 7, 2025
Exercise
is
one
of
the
most
important
activities
for
every
individual
due
to
its
proven
health
beneficials.
Several
investigations
have
highlighted
advantageous
impacts
aerobic
exercise,
largely
attributed
capacity
enhance
body's
capability
defend
against
threats
oxidative
stress.
The
information
currently
accessible
suggests
that
adding
regular
exercise
a
daily
routine
greatly
decreases
chances
developing
serious
cancer
and
passing
away.
An
unevenness
in
levels
free
radicals
antioxidant
defenses,
made
up
enzyme
non-enzyme
antioxidants,
results
pressure.
Generally,
an
imbalance
stress
triggers
creation
harmful
reactive
oxygen
or
nitrogen
compounds,
causing
development
progression
numerous
ailments,
including
cancer.
equilibrium
between
pro-oxidant
substances
direct
indicator
this
imbalance.
Green
tea
derivatives
are
rich
sources
bioactive
such
as
flavonoids
polyphenols
which
possess
abilities.
Moreover,
modulation
epigenetic
targets
well
inflammatory
pathways
ERK1/2
NF-κB
other
proposed
mechanisms
activity.
Recent
studies
demonstrate
promise
green
antioxidant,
showing
ability
decrease
likelihood
by
impacting
actions
like
cell
growth,
blood
vessel
formation,
spread
cells.
This
summary
will
concentrate
on
complex
network
different
related
physical
activity
consumption
tea.
In
particular,
focus
research
be
examining
how
contributes
investigating
potential
properties
tea,
interconnected
relationship
treatment
Elucidation
these
would
help
scientists
better
therapeutic
further
increase
current
anticancer
agents
efficiency.
Язык: Английский
Correction: Hao et al. Enhanced Chemoprevention of Prostate Cancer by Combining Arctigenin with Green Tea and Quercetin in Prostate-Specific Phosphatase and Tensin Homolog Knockout Mice. Biomolecules 2024, 14, 105
Biomolecules,
Год журнала:
2025,
Номер
15(2), С. 160 - 160
Опубликована: Янв. 21, 2025
The
authors
would
like
to
replace
Figure
3B
of
the
following
published
paper
[...]
Язык: Английский
Phytochemical Insights into Flavonoids in Cancer: Mechanisms, Therapeutic Potential, and the Case of Quercetin
Piero Alex Silva-Pinto,
Janaína Teixeira Costa de Pontes,
Brigitte Aguilar-Morón
и другие.
Heliyon,
Год журнала:
2025,
Номер
11(4), С. e42682 - e42682
Опубликована: Фев. 1, 2025
Язык: Английский
Quercetin in Oncology: A Phytochemical with Immense Therapeutic Potential
Current Drug Targets,
Год журнала:
2024,
Номер
25(11), С. 740 - 751
Опубликована: Июль 11, 2024
Quercetin
is
a
natural
flavonoid
with
various
pharmacological
actions
such
as
anti-inflammatory,
antioxidant,
antimicrobial,
anticancer,
antiviral,
antidiabetic,
cardioprotective,
neuroprotective,
and
antiviral
activities.
Looking
at
these
enormous
potentials,
researchers
have
explored
how
they
can
be
used
to
manage
numerous
cancers.
It's
been
studied
for
cancer
management
due
its
anti-angiogenesis,
anti-metastatic,
antiproliferative
mechanisms.
Despite
having
proven
activities,
the
clinical
use
of
quercetin
limited
first--
pass
metabolism,
poor
solubility,
bioavailability.
To
address
shortcomings,
fabricated
nanocarriers-based
formulations
fight
cancer.
The
present
review
overshadows
potential,
mechanisms,
application
nanoformulations
against
different
Teaser:
Explore
potential
Quercetin,
diverse
in
managing
Язык: Английский
Exploring the Flavonoid Biosynthesis Pathway of Two Ecotypes of Leymus chinensis Using Transcriptomic and Metabolomic Analysis
Agronomy,
Год журнала:
2024,
Номер
14(8), С. 1839 - 1839
Опубликована: Авг. 20, 2024
This
research
investigates
the
flavonoid
biosynthesis
pathways
of
two
ecotypes
Leymus
chinensis,
distinguished
by
their
gray-green
(GG)
and
yellow-green
(YG)
leaf
colors,
to
uncover
molecular
bases
adaptability
different
environmental
conditions.
By
integrating
comprehensive
transcriptomic
metabolomic
analyses,
we
identified
338
metabolites,
with
161
showing
differential
expression—124
upregulated
37
downregulated.
The
data
revealed
substantial
variation,
50,065
genes
differentially
expressed
between
ecotypes,
suggesting
complex
genetic
regulation
involving
20
enzyme-coding
genes.
KEGG
pathway
enrichment
analysis
further
highlighted
involvement
26
in
synthesis
four
distinct
types
indicating
sophisticated
modulation
these
pathways.
Our
results
demonstrate
that
GG
YG
chinensis
exhibit
profiles
gene
expression
patterns,
ecotype
a
higher
accumulation
quercetin
kaempferol
(increased
25%
33%,
respectively,
compared
YG),
enhanced
antioxidant
capacity.
Conversely,
displayed
broader
spectrum
possibly
an
adaptive
strategy
favoring
diverse
ecological
interactions.
show
divergent
strategies
stress.
study
highlights
crucial
role
metabolites
plant
adaptation
strategies,
enhancing
our
understanding
resilience
adaptability.
metabolic
observed
suggest
may
be
better
equipped
handle
oxidative
stress,
while
could
predisposed
emphasizes
value
applying
machine
learning
predicting
adaptability,
providing
new
perspective
for
future
exploration
how
plants
adapt
challenges.
Meanwhile,
information
gleaned
from
this
nuanced
offers
foundation
investigations
into
factors
involved
adaptation.
Язык: Английский
YTHDF1 gene inhibits epilepsy progression by epigenetic activation of PTEN gene
Heliyon,
Год журнала:
2024,
Номер
10(20), С. e39481 - e39481
Опубликована: Окт. 1, 2024
Язык: Английский
Molecular Signaling Pathways of Quercetin in Alzheimer’s Disease: A Promising Arena
Cellular and Molecular Neurobiology,
Год журнала:
2024,
Номер
45(1)
Опубликована: Дек. 24, 2024
Abstract
Alzheimer’s
disease
(AD)
is
a
neurodegenerative
characterized
by
cognitive
impairment
and
memory
deficit.
Even
with
extensive
research
studies,
presently,
there
no
effective
treatment
for
the
management
of
AD.
Besides,
most
drugs
used
in
AD
did
not
avert
neuropathology,
still
progressive
status.
For
example,
acetyl
cholinesterase
inhibitors
are
associated
many
adverse
effects,
such
as
insomnia
nightmares.
As
well,
acetylcholinesterase
augment
cholinergic
neurotransmission
leading
to
development
effects
related
high
acetylcholine
level,
salivation,
rhinorrhea,
vomiting,
loss
appetite,
seizure.
Furthermore,
tacrine
has
poor
bioavailability
causes
hepatotoxicity.
These
commonly
do
manage
original
those
reasons,
natural
products
were
repurposed
diseases.
It
been
shown
that
phytochemicals
produce
neuroprotective
against
progression
diseases
different
mechanisms,
including
antioxidant
anti-inflammatory
effects.
Quercetin
(QCN)
reported
exert
an
effect
other
lessening
oxidative
stress.
In
this
review,
electronic
databases
PubMed,
Scopus,
Web
Science
searched
possible
relevant
studies
article
linking
QCN
on
Findings
from
review
highlighted
mechanistic
signaling
pathways
regarding
Nevertheless,
precise
molecular
mechanism
was
completely
clarified.
Consequently,
aims
discuss
Язык: Английский