Impact of myosteatosis on prognosis in multiple myeloma patients: A subgroup analysis of 182 cases and development of a nomogram

Journal of bone oncology, Год журнала: 2025, Номер 51, С. 100670 - 100670

Опубликована: Март 11, 2025

This study aims to explore the prognostic value of myosteatosis in multiple myeloma (MM) and analyze factors influencing myosteatosis. A retrospective analysis was conducted on 182 patients treated for MM at our institution from 2009 2020 who underwent MRI examinations. The fatty infiltration rate (FIR) erector spinae multifidus muscles L3 level measured assess degree Patients were grouped based fracture presence median FIR, group differences compared, with P < 0.05 considered statistically significant. Survival fractures used as indicators, regression performed determine impact FIR these outcomes patients. analyzed, relationship between prognosis further analyzed within its sensitive subgroups. Finally, a nomogram established validated. Significant observed non-fracture groups lactate dehydrogenase, serum phosphorus, visual analogue scale, oswestry disability index (P 0.05). When (28.89 %), there significant age, sex, body mass (BMI), red blood cell (RBC) count, hemoglobin, hematocrit, albumin, index, incidence Univariate COX indicated that had no survival (HR = 0.999, 0.852), log-rank test 0.11 when by cut-off 33.67 %. Multivariate logistic is an independent predictor (OR 1.054, 0.000). linear revealed RBC BMI are not grouped, FIR's prediction showed interaction or > In subgroups ≥ 25 kg/m2 count 3.68 × 10^12/L, lost predictive significance fractures. model C-index 0.777, calibration curve, decision curve analysis, clinical all validated effectiveness. Myosteatosis characterized reliable but effective predicting closely related back pain functional impairment. significantly associated BMI.

Язык: Английский

A novel defined risk signature of ferroptosis-related lncRNAs for predicting prognosis, immune infiltration, and chemotherapy response in multiple myeloma

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 11, 2025

Язык: Английский

RNA methylation: A new perspective in osteoarthritis research

Gene, Год журнала: 2025, Номер unknown, С. 149518 - 149518

Опубликована: Апрель 1, 2025

Язык: Английский