Hydrogen Sulfide Promotes Functional Endometrium Recovery via Regulating Pyroptosis in Severe Endometrial Injury: A Prospective Laboratory Based Randomized Control Trial

Clinical and Experimental Obstetrics & Gynecology, Год журнала: 2025, Номер 52(1)

Опубликована: Янв. 16, 2025

Background: Severe endometrial injury constitutes a significant risk to female fertility, often leading the development of intrauterine adhesions. Pyroptosis, form programmed cell death associated with inflammation, is initiated by cleavage gasdermin family proteins caspase, which has been implicated in injury. In recent years, hydrogen sulfide (H2S), gaseous signaling molecule, exerts regulatory effects on pyroptosis diverse pathological processes. The aim this study elucidate role H2S facilitating functional recovery endometrium following murine model. Methods: A prospective laboratory based randomized control trial was performed evaluate protective Ethanol-induced mouse models were established and donor sodium hydrosulfide (NaHS) randomly administered injured mice. Western blot analysis conducted assess changes expression endogenous metabolism pyroptosis-related markers histological (Hematoxylin & Eosin Masson staining) employed examine alterations morphology. Finally, fertility test restoration uterine function. Results: Following injury, key enzymes-cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), 3-mercaptopyruvate sulfurtransferase (MST)-is significantly reduced, while levels are elevated (p < 0.05). However, treatment resulted an increase enzymes decrease pyroptosis-associated compared Model group Moreover, morphology embryo count showed most pronounced improvement Conclusions: This confirms therapeutic efficacy revealed its potential mechanism, offering promising avenue for patients severe

Язык: Английский

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A Narrative Review of the Expression and Role of Nitric Oxide in Endometriosis

Antioxidants, Год журнала: 2025, Номер 14(3), С. 247 - 247

Опубликована: Фев. 20, 2025

Nitric oxide (NO) is a key signaling molecule involved in cellular communication and plays critical role various biological processes. Given its dual the pathogenesis of endometriosis, we conducted systematic literature review to explore mechanisms further. Numerous studies have investigated expression NO diseases, including those field gynecology. However, endometriosis remain topic ongoing debate. Therefore, comprehensive using Cochrane Library, EMBASE, Google Scholar, PubMed, SCOPUS databases evaluate induction endometriosis. Of 27 papers ultimately reviewed, 22 (81.4%) reported that contributes 3 (11.1%) suggested acts as protective mechanism against 2 (7.4%) found no association between The levels were associated with pregnancy, infertility, menstruation, pelvic pain. Research on rats mice demonstrated NO, nNOS, eNOS, iNOS play significant roles development Most increased are

Язык: Английский

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Hydrogen Sulfide-Responsive MRI Probe for Imaging Colon Cancer in Mice

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

Hydrogen sulfide (H2S), a significant gaseous signaling molecule, is highly expressed in colon cancer. However, realizing sensitive and specific imaging of H2S deep cancer tissues remains an important challenge. In order to overcome this limitation, we have developed H2S-responsive magnetic probe (HRMP) with high sensitivity specificity. HRMP synthesized using superparamagnetic iron oxide Mn-porphyrin, coated hydrogen sulfide-responsive polymer. Upon reaction H2S, the released nanoparticles aggregate, producing enhanced transverse relaxivity (r2) through dipolar effect. Incorporation ortho azide group ensures that specifically responds reacting swiftly within 2 h induce change T2 relaxation time. Additionally, by precisely tuning feeding ratio Mn-porphyrin oxide, was endowed sensitivity, achieving detection limit as low 8.7 μM. studies HCT116 cancer, where overexpressed, generated distinct negative contrast at tumor site. shows potential for vivo offering promise early diagnosis tumors.

Язык: Английский

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Reconnecting the roots of hydrogen sulfide (H2S) with medicinal chemistry: Lessons accomplished and challenges so far

Bioorganic Chemistry, Год журнала: 2025, Номер 161, С. 108569 - 108569

Опубликована: Май 8, 2025

Язык: Английский

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Hydrogen sulfide and its donors for the treatment of traumatic brain injury: A comprehensive review

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125792 - 125792

Опубликована: Май 1, 2025

Язык: Английский

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