Phytomedicine, Год журнала: 2024, Номер 136, С. 156343 - 156343
Опубликована: Дек. 21, 2024
Язык: Английский
Biomedical Reports, Год журнала: 2025, Номер 22(3)
Опубликована: Янв. 8, 2025
The advent of personalized and precision medicine has revolutionized oncology treatment gynecological cancer. These innovative approaches tailor treatments to individual patient profiles beyond genetic markers considering environmental lifestyle factors, thereby optimizing therapeutic efficacy minimizing adverse effects. Precision uses advanced genomic technologies such as next‑generation sequencing perform comprehensive tumor profiling. This allows identification distinct mutations, expression patterns signaling pathway alterations, revealing the complex molecular landscape cancer ovarian, cervical uterine A major challenge in treating these cancers is their inherent heterogeneity, which can influence behavior, therapy response prognosis. aims overcome this by identifying biomarkers drivers for targeted selection. For example, breast (BRCA) gene mutations ovarian guided use poly (ADP‑ribose) polymerase inhibitors, leading more effective with fewer side Similar therapies immunotherapies have also been developed cancer, marking progress toward care. Future directions emphasize importance profiling development therapies. By understanding unique features each patient, clinicians select most strategies improve outcomes quality life.
Язык: Английский
Процитировано
1
Cancers, Год журнала: 2025, Номер 17(2), С. 269 - 269
Опубликована: Янв. 15, 2025
Background: The phosphoinositide 3-kinase (PI3K) pathway is activated in multiple cancers. However, the significance of PIK3R1 encoding PI3K regulatory subunit, an inhibitor catalytic subunit encoded by PIK3CA, ovarian cancer development largely unknown. Methods: Here, we investigated genomic alterations and gene expression direct sequencing qPCR methods 197 results were correlated with clinicopathological molecular variables patient outcomes. Results: In addition to mutations (3.5%) allelic losses (28.4%), observed a very high frequency decreased mRNA levels carcinomas (95.8%). Tumors mostly represented low-stage cancers endometrioid clear-cell type. deletion underexpression shared similar phenotypes high-grade (p = 0.003 p 0.025, respectively). Allelic loss was also associated advanced stages 0.003) serous histotypes 0.004). copy number 0.009). coexisted PTEN 0.041), whereas linked PIK3CA amplification 0.038 0.033, Low diminished probability complete response (OR 0.07, 0.03) patients treated platinum-based regimens. Conclusions: may contribute different malignant potential changes. aberrations suggests their importance deregulation, they potentially serve as alternative markers for therapy these inhibitors.
Язык: Английский
Процитировано
0
Pathogens, Год журнала: 2025, Номер 14(2), С. 140 - 140
Опубликована: Фев. 3, 2025
Ovarian cancer (OC) remains the most lethal gynecologic malignancy with limited effective treatment options. Oncolytic viruses (OVs) have emerged as a promising therapeutic approach for treatment, capable of selectively infecting and lysing cells while stimulating anti-tumor immune responses. Preclinical studies demonstrated significant tumor regression prolonged survival in OC models using various OVs, such herpes simplex. Early-phase clinical trials shown favorable safety profile, though impact on patient has been modest. Current research focuses combining OVs other treatments like checkpoint inhibitors to enhance their efficacy. We provide comprehensive overview current understanding future directions utilizing management OC.
Язык: Английский
Процитировано
0
European journal of medical research, Год журнала: 2025, Номер 30(1)
Опубликована: Март 4, 2025
As one member of the Forkhead Box transcription factor, J2 (FOXJ2) is involved in diverse cancers. At present, specific role and mechanism FOXJ2 ovarian cancer (OC) have not been fully addressed, which allows us to fill blank. Accordingly, expression OC cells epithelial was quantified via real-time qPCR. Following transfection, cell counting kit-8, Transwell, wound healing flow cytometry assays were performed measure proliferation, metastasis, apoptosis cycle A2780 HEY. Further, qPCR Western blotting both employed for quantification on levels as well phosphoinositide 3-kinase (PI3K) protein kinase B (AKT) (in unphosphorylated phosphorylated forms). Based results, highly-expressed (P < 0.05). Silencing resulted attenuated reduced numbers migrating invading cells, decreased apoptotic capacity, arrest G1/S phase In addition, knockdown caused downward trend phosphorylation level PI3K AKT The silencing could repress growth metastasis potentials cause vitro, possibly achieved targeting PI3K/AKT pathway.
Язык: Английский
Процитировано
0
Current Research in Toxicology, Год журнала: 2025, Номер unknown, С. 100230 - 100230
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 11927 - 11927
Опубликована: Ноя. 6, 2024
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy worldwide. Due to its nonspecific symptoms and unreliable screening tools, EOC not diagnosed at an early stage in cases. Unfortunately, despite achieving initial remission after debulking surgery platinum-based chemotherapy, patients experience recurrence of disease. The limited therapy approaches have encouraged scientists search for new detection therapeutic strategies. In this review, we discuss role folate receptor alpha (FRα) development potential application as a biomarker molecular target designing treatment methods. We summarize mechanisms action various strategies based on FRα, including MABs (monoclonal antibodies), ADCs (antibody-drug conjugates), FDCs (folate-drug SMDCs (small molecule-drug vaccines, CAR-T (chimeric antigen T) cells, present significant clinical trials some FRα-based drugs. Furthermore, pros cons different FR-based therapies, highlighting mirvetuximab soravtansine (MIRV) currently promising EOC-targeting drug.
Язык: Английский
Процитировано
1
Translational Oncology, Год журнала: 2024, Номер 51, С. 102226 - 102226
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
1
Biomedical Engineering and Computational Biology, Год журнала: 2024, Номер 15
Опубликована: Янв. 1, 2024
Cancer-associated fibroblasts (CAFs) play critical roles in the metastasis and therapeutic response of high-grade serous ovarian cancer (HGSC). Our study intended to select HGSC patients with unfavorable prognoses responses based on CAF-enriched prognostic genes. The bulk RNA single-cell sequencing (scRNA-seq) data tumor tissues were collected from TCGA GEO databases. infiltrated levels immune stromal cells estimated by multiple deconvolution algorithms verified through immunohistochemical analysis. univariate Cox regression analyses used identify Gene Set Enrichment Analysis (GSEA) was conducted annotate enriched gene sets. Genomics Drug Sensitivity Cancer (GDSC) database explore potential alternative drugs. We found infiltered CAFs remarkedly elevated advanced metastatic identified hundreds genes specifically CAFs. Then we selected 6 which reclassified into 2 subclusters discrepancy prognoses. Further analysis revealed that cluster-2 tended undergo poor traditional chemotherapy immunotherapy. Subsequently, 24 novel drugs for patients. Moreover, discovered a positive correlation between monocytes/macrophages tissues. Collectively, our successfully different subgroups have current methods.
Язык: Английский
Процитировано
0
Phytomedicine, Год журнала: 2024, Номер 136, С. 156343 - 156343
Опубликована: Дек. 21, 2024
Язык: Английский
Процитировано
0