Regenerative medicine and congenital heart diseases: Current approaches and future directions DOI

Buse Sanli,

Mohammadreza Dastourı

Опубликована: Окт. 1, 2024

Congenital heart disease (CHD) is one of the most common disorders in newborns. The may be present as many 0.013% Even with vast development medical field and surgical interventions, fact remains that serious CHDs are leading cause death disability for children who have to endure long-term problems such failure other systemic issues. About 80% infants toddlers potential reach adulthood. Hence, cost effectiveness care patients become complex. Advances regenerative medicine, specifically stem cell therapies, significantly progressed treating CHD. Different cells were used together corresponding findings, success, separate preclinical works. These methods planned treat problems, thus reducing complications improving heart’s overall function. However, drawbacks like immune rejection, scalability, safety hinder application these approaches clinical practice. This paper comprehensively explores existing CHD management techniques including tissue engineering, gene therapy, biomaterials development. Furthermore, issues 3D bioprinting, CRISPR editing, use organoids modeling also discussed. Steady progress has been realized diseases using cells. ethical considerations legislation on cells, general, should a part study review process already safe fair patient access. key curing will overcome challenges bring successes life clinic. By enhancing our knowledge about formation refinement treatments, we would more success stories help them obtain better quality brighter future.

Язык: Английский

From injury to repair: the therapeutic potential of induced pluripotent stem cells in heart failure DOI Creative Commons
Tadahisa Sugiura, Sheeza Nawaz, Dhienda C. Shahannaz

и другие.

Regenerative medicine reports ., Год журнала: 2025, Номер 2(1), С. 22 - 30

Опубликована: Март 1, 2025

Heart failure is a complex clinical syndrome characterized by the heart’s inability to pump sufficient blood meet body’s metabolic demands, resulting in symptoms such as dyspnea, fatigue, and fluid retention. Despite significant advances pharmacological treatments device therapies, prognosis for patients with advanced heart remains poor. This underscores urgent need innovative regenerative therapies aimed at restoring cardiac function improving quality of life suffering from this debilitating condition. article provides comprehensive overview pathophysiologic mechanisms underlying end-stage failure, which include myocardial systolic diastolic dysfunction, neuroendocrine activation, inflammation, oxidative stress. Collectively, these lead progressive deterioration structure function, culminating failure. The also examines differences between ischemic non-ischemic cardiomyopathies their implications treatment strategies prognosis. Furthermore, review explores application medicine focusing on its potential repair functional recovery. In field medicine, induced pluripotent stem cells derived cardiomyocytes are considered cutting-edge technologies repair. Induced can differentiate into cardiomyocytes, thereby offering new hope regeneration. However, current research faces several challenges, including maturity integration immunogenicity concerns, difficulties scaling up production applications. Additionally, ethical issues related cell technology, sourcing tumorigenic risks, must be carefully addressed. highlights technology treating while emphasizing complexities involved transitioning laboratory practice.

Язык: Английский

Процитировано

0
Bioengineering Approaches to In Vitro Modeling of Genetic and Acquired Cardiac Diseases DOI Creative Commons

Linqi Jin,

Boeun Hwang,

Sarah Rezapourdamanab

и другие.

Current Cardiology Reports, Год журнала: 2025, Номер 27(1)

Опубликована: Март 20, 2025

Abstract Purpose of Review This review aims to explore recent advancements in bioengineering approaches used developing and testing vitro cardiac disease models. It seeks find out how these tools can address the limitations traditional models be applied improve our understanding mechanisms, facilitate preclinical drug screening, equip development personalized therapeutics. Recent Findings Human induced pluripotent stem cells have enabled generation diverse cell types patient-specific Techniques like 3D tissue engineering, heart-on-a-chip platforms, biomechanical conditioning, CRISPR-based gene editing faithful recreation complex microenvironments conditions. These advanced study both genetic acquired disorders. Summary Bioengineered are transforming basic science clinical research cardiovascular by improving biomimicry complexity analogues, increasing throughput reproducibility screening as well offering patient specificity. Despite challenges scalability functional maturity, integrating multiple techniques with analytical modeling platforms holds promise for future precision medicine therapeutic innovations.

Язык: Английский

Процитировано

0
Engineering considerations in the design of tissue specific bioink for 3D Bioprinting applications DOI

Shivi Tripathi,

Madhusmita Dash,

Ruchira Chakraborty

и другие.

Biomaterials Science, Год журнала: 2024, Номер unknown

Опубликована: Окт. 23, 2024

Designing tissue-specific bioinks to replicate actual tissue environments and desired biomechanical properties.

Язык: Английский

Процитировано

3
Current Status of Bioprinting Using Polymer Hydrogels for the Production of Vascular Grafts DOI Creative Commons
Jana Matějková, Denisa Kaňoková, Roman Matějka

и другие.

Gels, Год журнала: 2024, Номер 11(1), С. 4 - 4

Опубликована: Дек. 26, 2024

Cardiovascular disease is one of the leading causes death and serious illness in Europe worldwide. Conventional treatment-replacing damaged blood vessel with an autologous graft-is not always affordable for patient, so alternative approaches are being sought. One such approach patient-specific tissue bioprinting, which allows precise distribution cells, material, biochemical signals. With further developmental support, a functional replacement or can be created. This review provides overview current state bioprinting vascular graft manufacturing summarizes hydrogels used as bioinks, material carriers, methods fabrication used, especially vessels smaller than 6 mm, most challenging cardiovascular replacements. The divided into several sections-self-supporting grafts based on simple 3D bioinks scaffolds made decellularized nanofibrous material.

Язык: Английский

Процитировано

0
Regenerative medicine and congenital heart diseases: Current approaches and future directions DOI

Buse Sanli,

Mohammadreza Dastourı

Опубликована: Окт. 1, 2024

Congenital heart disease (CHD) is one of the most common disorders in newborns. The may be present as many 0.013% Even with vast development medical field and surgical interventions, fact remains that serious CHDs are leading cause death disability for children who have to endure long-term problems such failure other systemic issues. About 80% infants toddlers potential reach adulthood. Hence, cost effectiveness care patients become complex. Advances regenerative medicine, specifically stem cell therapies, significantly progressed treating CHD. Different cells were used together corresponding findings, success, separate preclinical works. These methods planned treat problems, thus reducing complications improving heart’s overall function. However, drawbacks like immune rejection, scalability, safety hinder application these approaches clinical practice. This paper comprehensively explores existing CHD management techniques including tissue engineering, gene therapy, biomaterials development. Furthermore, issues 3D bioprinting, CRISPR editing, use organoids modeling also discussed. Steady progress has been realized diseases using cells. ethical considerations legislation on cells, general, should a part study review process already safe fair patient access. key curing will overcome challenges bring successes life clinic. By enhancing our knowledge about formation refinement treatments, we would more success stories help them obtain better quality brighter future.

Язык: Английский

Процитировано

0