International Journal of Molecular Medicine, Год журнала: 2024, Номер 54(5)

Опубликована: Сен. 17, 2024

Diabetic kidney disease (DKD) is the leading cause of chronic and end‑stage renal disease, characterized by persistent proteinuria decreased glomerular filtration rate. Despite extensive efforts, increasing incidence highlights urgent need for more effective treatments. Histone methylation a crucial epigenetic modification, its alteration can destabilize chromatin structure, thereby regulating transcriptional activity specific genes. serves substantial role in onset progression various diseases. In patients with DKD, changes histone are pivotal mediating interactions between genetic environmental factors. Targeting these modifications shows promise ameliorating histological manifestations, tissue fibrosis proteinuria, represents novel therapeutic frontier potential to halt DKD progression. The present review focuses on alterations during development systematically summarizes impact parenchymal cells underscores targeted improving outcomes.

Язык: Английский