GIP/GLP-1 DUAL AGONIST TIRZEPATIDE AMELIORATES RENAL ISCHEMIA/REPERFUSION DAMAGE IN RATS
International Journal of Applied Pharmaceutics,
Год журнала:
2025,
Номер
unknown, С. 165 - 173
Опубликована: Март 7, 2025
Objective:
Renal
Ischemia/Reperfusion
Injury
(RIRI)
initiates
a
cascade
of
deleterious
events
resulting
in
acute
kidney
injury
with
high
mortality
rates.
Tirzepatide
has
anti-inflammatory,
anti-apoptotic
and
antioxidant
as
well
activation
both
autophagy
Protein
Kinase
B
(PKB
or
Akt)
signaling
pathway.
This
study
examines
the
potential
nephroprotective
effect
tirzepatide
against
RIRI
rats.
Methods:
Twenty-eight
male
rats
(Sprague
Dawley)
were
split
into
four
groups:
sham,
(IRI),
Distilled
Water
(D.
W)
tirzepatide.
The
Sham
group
underwent
identical
procedures
without
bilateral
renal
pedicle
clamping,
whereas
IRI
was
exposed
to
30
min
ischemia
followed
by
24
h
reperfusion.
vehicle
received
distilled
water
intraperitoneally
2
before
ischemia,
3
mg/kg
ischemia.
Study
parameters
including
urea,
creatinine,
Kidney
Molecule-1
(KIM-1),
interleukin-6
(IL-6),
caspase-3,
Akt,
autophagic
protein
microtubule-associated
1
light
chain
3-B
(LC3-B)
glutathione
(GSH),
histopathological
changes
examined.
Results:
resulted
significant
elevation
serum
creatinine
levels
KIM-1,
IL-6,
LC3-B
while
concurrently
reduction
GSH
level.
treatment
diminished
severity
damage
alleviating
inflammatory
apoptotic
markers,
augmenting
activity
improving
consequences.
Conclusion:
elucidates
effects
RIRI,
via
its
antioxidant,
antiapoptotic
properties
Akt
Язык: Английский
SID/SIEDP expert consensus on optimizing clinical strategies for early detection and management of wolfram syndrome
Journal of Endocrinological Investigation,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
Wolfram
Syndrome
(WFS)
is
a
rare,
multisystemic,
degenerative
disease
leading
to
premature
death.
Clinical
and
genetic
heterogeneity
makes
WFS
diagnosis
management
challenging.
The
Italian
Society
of
Diabetes
(SID)
the
for
Pediatric
Endocrinology
Diabetology
(SIEDP)
convened
an
expert
panel
professional
healthcare
practitioners
provide
up-to-date
knowledge
about
pathophysiology,
clinical
presentation
treatment
WFS,
recommendations
earlydetection
optimal
management.
consensus
recommends
revision
diagnostic
protocols
include
testing
comprehensive
multidisciplinary
evaluations
ensure
accurate
advocates
personalized
plans
tailored
unique
needs
each
patient,
with
emphasis
on
exploring
new
potential
drug
therapies.
A
holistic
care
model
that
addresses
medical,
psychological,
social
challenges
faced
by
patients
their
families
strongly
endorsed.
opinion
underscores
importance
educating
professionals
enhance
early
intervention,
aiming
improve
outcomes
through
practical
evidence-based
strategies.
Язык: Английский