Biomolecules, Год журнала: 2024, Номер 15(1), С. 10 - 10

Опубликована: Дек. 25, 2024

Schizophrenia is a complex heterogenous disorder thought to be caused by interactions between genetic and environmental factors. The theories developed explain the etiology of schizophrenia have focused largely on dysfunction neurotransmitters such as dopamine, serotonin glutamate with their receptors, although research in past several decades has indicated strongly that other factors are also involved role neuroglial cells psychotic disorders including should given more attention. Although glia were originally present brain only support neurons physical, metabolic nutritional capacity, it become apparent these variety important physiological roles abnormalities function may make significant contributions symptoms schizophrenia. In paper, we review microglia, astrocytes oligodendroglia aspects transmitter dysregulation, neuro-inflammation, oxidative stress, synaptic function, gut microbiome, myelination blood-brain barrier appear affect cause, development treatment We crosstalk oligodendrocytes effects antipsychotics neuroglia. Problems associated studies specific biomarkers for discussed.

Язык: Английский