Technological Innovations in Tropical Diseases Treatment and Therapeutics
Health information science,
Год журнала:
2025,
Номер
unknown, С. 287 - 308
Опубликована: Янв. 1, 2025
Язык: Английский
Revolutionizing immunization: a comprehensive review of mRNA vaccine technology and applications
Virology Journal,
Год журнала:
2025,
Номер
22(1)
Опубликована: Март 12, 2025
Messenger
RNA
(mRNA)
vaccines
have
emerged
as
a
transformative
platform
in
modern
vaccinology.
mRNA
vaccine
is
powerful
alternative
to
traditional
due
their
high
potency,
safety,
and
efficacy,
coupled
with
the
ability
for
rapid
clinical
development,
scalability
cost-effectiveness
manufacturing.
Initially
conceptualized
1970s,
first
study
about
effectiveness
of
against
influenza
was
conducted
1993.
Since
then,
development
has
rapidly
gained
significance,
especially
combating
COVID-19
pandemic.
Their
unprecedented
success
during
pandemic,
demonstrated
by
Pfizer-BioNTech
Moderna
vaccines,
highlighted
potential.
This
review
provides
comprehensive
analysis
technology,
detailing
structure
its
mechanism
action
inducing
immunity.
Advancements
nanotechnology,
particularly
lipid
nanoparticles
(LNPs)
delivery
vehicles,
revolutionized
field.
The
manufacturing
processes,
including
upstream
production,
downstream
purification,
formulation
are
also
reviewed.
progress
targeting
viruses
causing
infectious
diseases
discussed,
emphasizing
versatility
therapeutic
Despite
success,
faces
several
challenges,
improved
stability
reduce
dependence
on
cold
chain
logistics
transport,
enhanced
mechanisms
target
specific
tissues
or
cells,
addressing
risk
rare
adverse
events.
High
costs
associated
encapsulation
LNPs
potential
unequal
global
access
further
complicate
widespread
adoption.
As
world
continues
confront
emerging
viral
threats,
overcoming
these
challenges
will
be
essential
fully
harness
vaccines.
It
anticipated
that
play
major
role
defining
shaping
future
health.
Язык: Английский
Nanoparticle-mediated enhancement of DNA Vaccines: Revolutionizing immunization strategies
Pegah Yaraghi,
Abbas Kheyri,
Narges Mikaeili
и другие.
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
302, С. 140558 - 140558
Опубликована: Фев. 1, 2025
Язык: Английский
Personalized precision: Revolutionizing cancer treatment with mRNA-based vaccines in melanoma therapy
Advances in immunology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Mycoplasma bovis : A review of vaccination and diagnostic initiatives
CABI Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Abstract
Mycoplasma
bovis
infections
in
cattle
constitute
a
worldwide
problem
with
significant
detrimental
economic
impacts
on
industry.
Mastitis,
pneumonia,
arthritis,
keratoconjunctivitis,
otitis
media
and
genital
disorders
are
its
clinical
manifestations.
Presently,
no
vaccines
commercially
available;
antimicrobial
resistance
is
increasing;
diagnostic
sensitivity
testing
needs
to
be
improved;
new
rapid
diagnosis
kits
eminent
for
implementation
of
treatment
antimicrobials.
We
conducted
systematic
search
databases
such
as
PubMed,
Scopus,
Web
Science,
Google
Scholar,
AGRIS
African
Journals
Online
(AJOL),
from
1995
2024.
Searched
keywords,
as,
bovis,
M
:
vaccine
development,
techniques
strain
variability
using
the
predefined
criteria
were
used
address
review
objectives.
Although
they
have
preventative
function,
–
killed,
live
attenuated,
subunit
types
face
difficulties
because
M.
strains
vary
widely.
Every
approach
has
own
set
benefits
drawbacks,
those
that
been
studies
include
conventional
culture
identification,
serological
testing,
immunohistochemical
demonstration
tissues,
sophisticated
molecular
like
PCR,
qPCR,
next-generation
sequencing.
For
early
detection,
successful
treatment,
vaccination
efficacy
monitoring,
accurate
crucial.
Future
directions
managing
-associated
diseases
improving
accessibility
creating
broad-spectrum
vaccinations.
By
incorporating
these
developments,
it
may
possible
enhance
health
cattle,
promote
sustainability
livestock
production,
increase
food
security.
This
points
urgent
need
further
research
innovation
advancement
support
Язык: Английский