Metabolic and Mitochondrial Dysregulations in Diabetic Cardiac Complications
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 3016 - 3016
Опубликована: Март 26, 2025
The
growing
prevalence
of
diabetes
highlights
the
urgent
need
to
study
diabetic
cardiovascular
complications,
specifically
cardiomyopathy,
which
is
a
diabetes-induced
myocardial
dysfunction
independent
hypertension
or
coronary
artery
disease.
This
review
examines
role
mitochondrial
in
promoting
cardiac
and
metabolic
mechanisms
such
as
hyperglycaemia-induced
oxidative
stress.
Chronic
hyperglycaemia
insulin
resistance
can
activate
harmful
pathways,
including
advanced
glycation
end-products
(AGEs),
protein
kinase
C
(PKC)
hexosamine
signalling,
uncontrolled
reactive
oxygen
species
(ROS)
production
mishandling
Ca2+
transient.
These
processes
lead
cardiomyocyte
apoptosis,
fibrosis
contractile
dysfunction.
Moreover,
endoplasmic
reticulum
(ER)
stress
dysregulated
RNA-binding
proteins
(RBPs)
extracellular
vesicles
(EVs)
contribute
tissue
damage,
drives
function
towards
heart
failure
(HF).
Advanced
patient-derived
induced
pluripotent
stem
cell
(iPSC)
organoids
(iPS-COs)
are
transformative
tools
for
modelling
cardiomyopathy
capturing
human
disease's
genetic,
epigenetic
hallmarks.
iPS-COs
may
facilitate
precise
examination
molecular
pathways
therapeutic
interventions.
Future
research
directions
encourage
integration
models
with
mechanistic
techniques
promote
novel
strategies.
Язык: Английский
Congenital Heart Diseases and Neurodevelopmental Disorders
JACC Basic to Translational Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Congenital
heart
disease
(CHD)
is
the
primary
cause
of
birth
defects,
affecting
9
per
1,000
live
births.
Up
to
50%
them
will
develop
neurodevelopmental
disorders,
two-thirds
which
being
unexplained
by
postnatal
risk
factors.
Recent
advances
suggest
a
triangular
relationship
between
placenta
and
fetal
brain
in
CHD,
consistent
with
Developmental
Origins
Health
Disease
hypothesis,
ie,
utero
programming
early
later-in-life
noncommunicable
cardiometabolic
mental
diseases.
The
current
review
provides
comprehensive
evidence
placental,
cardiac,
cerebral
tissues
interactions,
details
how
placental
dysregulation
may
affect
vasculogenesis,
angiogenesis
neural
tube
closure,
hemodynamics,
energy
supply,
endocrine
function,
epigenetic
regulation
developing
brain.
Future
studies
should
include
research,
since
identifying
biomarkers
would
allow
identification
CHD
infants
at
higher
for
leading
targeted
preventive
personalized
interventions.
Язык: Английский