Bacterial cellulose in transdermal drug delivery systems: Expanding horizons in multi-scale therapeutics and patient-centric approach
International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
unknown, С. 125254 - 125254
Опубликована: Янв. 1, 2025
Язык: Английский
Optimization of Gelatin and Crosslinker Concentrations in a Gelatin/Alginate-Based Bioink with Potential Applications in a Simplified Skin Model
Molecules,
Год журнала:
2025,
Номер
30(3), С. 649 - 649
Опубликована: Фев. 1, 2025
Three-dimensional
bioprinting
allows
for
the
fabrication
of
structures
mimicking
tissue
architecture.
This
study
aimed
to
develop
a
gelatin-based
bioink
bioprinted
simplified
skin
model.
The
printability
and
chemical-physical
properties
were
evaluated
by
varying
concentrations
gelatin
(10,
15,
20%)
in
semi-crosslinked
alginate-based
calcium
chloride
(100,
150,
200
mM)
post-printing
crosslinking.
For
increasing
concentration,
formulations
have
shear
thinning
behavior
with
viscosity,
filament
bending
angle
increases,
spreading
ratio
value
approaches
1,
shape
fidelity
printing
resolution
improve.
However,
formulation
containing
20%
was
not
homogeneous,
resulting
also
poor
properties.
morphology
pores,
degradation,
swelling
depend
on
CaCl2
concentrations,
but
significant
way.
samples
15%
crosslinked
150
mM
been
selected
bilayer
model
human
fibroblasts
keratinocytes.
showed
homogeneous
distribution
viable
proliferating
cells
over
up
14
days
vitro
culture.
allowed
3D
model,
potential
applications
bioactivity
pro-reparative
molecules
drug
evaluation.
Язык: Английский
Establishing an Evidence-Based System for Cosmetic Safety and Efficacy Evaluation
IntechOpen eBooks,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
In
the
era
of
booming
cosmetics
industry,
safety
and
efficacy
evaluation
have
become
crucial
aspects
in
ensuring
product
quality
meeting
consumer
demands.
The
Chinese
market
has
witnessed
rapid
development.
With
an
increasing
emphasis
on
cosmetics,
a
relatively
comprehensive
system
been
gradually
established.
As
pioneers
Europe
United
States
also
possess
mature
advanced
experience
this
regard.
Based
years
work
fields
related
to
evaluation,
author
chapter
summarized
characteristics
China,
Europe,
area.
For
entry
points
include
raw
materials,
packaging
chemistry
microbiology,
as
well
human
testing.
it
is
classified
into
categories
such
for
freckle—removing
whitening,
anti-hair
loss,
sun
protection,
anti-aging,
acne—treatment,
repair,
soothing,
those
suitable
sensitive
skin.
By
integrating
application
new
AI
technologies,
presents
scientific
evidence-based
boost
high-quality
development
industry.
Язык: Английский
The landscape of biofilm models for phage therapy: mimicking biofilms in diabetic foot ulcers using 3D models
Frontiers in Microbiology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 24, 2025
Diabetic
foot
ulcers
(DFU)
affect
up
to
15-25%
of
patients
suffering
from
diabetes
and
are
considered
a
global
health
concern.
These
may
result
in
delayed
wound
healing
chronic
infections,
with
the
potential
lead
amputations.
It
has
been
estimated
that
85%
diabetes-related
amputations
preceded
by
diagnosis
DFU.
A
critical
factor
persistence
this
disease
is
presence
polymicrobial
biofilms,
which
generally
include
Staphylococcus
aureus,
Pseudomonas
aeruginosa,
Escherichia
coli.
The
involvement
diabetic
comorbidities
such
as
ischemia,
hyperglycemia,
immune-compromised
status
creates
perfect
niche
for
these
bacteria
evade
body's
immune
response
persist
biofilms.
Bacteriophage
therapy
can
target
lyse
specific
emerging
an
effective
treatment
biofilm-related
infections.
While
shows
promise
addressing
wounds,
our
current
models,
including
animal
static
systems,
fail
capture
full
complexity
Innovative
approaches
3D
bioengineered
skin
organoid
hydrogel-based
systems
being
developed
simulate
DFU
microenvironments
more
accurately
without
using
ex
vivo
or
tissues.
advanced
models
evaluating
bacteriophage
efficacy
biofilm-associated
DFU,
aiming
enhance
preclinical
assessments
improve
therapeutic
outcomes
patients.
Язык: Английский
Biological Effects of a <i>Bacillus sp</i>. Ferment Extract through the Protection of Key Features Associated with Aging in Human Skin Biopsies
Mauricio Valerio-Santiago,
María C. Lidón-Moya,
J. Gálvez
и другие.
Journal of Cosmetics Dermatological Sciences and Applications,
Год журнала:
2025,
Номер
15(01), С. 62 - 78
Опубликована: Янв. 1, 2025
Язык: Английский
Topical Administration of Vitamin D2 Combined with Colloidal Silver Nanoparticles Promotes Wound Repair and Protection Against Skin Irritation and UVB Irradiation in 3D Reconstructed Human Skin Models
Pharmaceutics,
Год журнала:
2025,
Номер
17(4), С. 472 - 472
Опубликована: Апрель 4, 2025
Background/Objectives:
There
is
a
great
demand
for
novel,
multipurpose,
natural
skin-care
products
in
the
global
skin
repair
and
sun
protection
markets.
Within
this
framework,
potential
benefits
of
topical
Vitamin
D2
(VD2)
administration
combination
with
silver
nanoparticles
(AgNPs)
were
examined.
Methods:
Evaluating
efficacy
VD2+AgNP
cream
wound
healing,
irritation
UVB
irradiation
necessitated
preclinical
testing
using
reconstructed
human
equivalent
models
(prepared
from
foreskins)
containing
both
fully
stratified
epidermal
layer
underlying
dermis.
Results:
Application
significantly
improved
healing
by
stimulating
keratinocyte
re-epithelialization
dermal
fibroblast
migration
subjected
to
full-thickness
(scratch
biopsy
punch)
wounds,
compared
untreated
models.
The
cream,
administered
prior
induction
5%
sodium
dodecyl
sulfate
(SDS)
afforded
ameliorating
cell
viability
thickness
interleukin-1alpha
levels.
exposure
(50
mJ/cm2)
reduced
(associated
increased
breakage),
as
well
basal
Ki67
supra-basal
involucrin
expression,
CTRL
sham-irradiated
(protective
capacity)
showed
greater
minimizing
damage.
This
was
reflected
higher
lower
breakage,
where
applied
following
(curative
capacity).
Conclusions:
shows
multipurpose
protection.
molecular
mechanisms
remain
be
investigated.
Язык: Английский
Efficacy of an Innovative Poly-Component Formulation in Counteracting Human Dermal Fibroblast Aging by Influencing Oxidative and Inflammatory Pathways
Biomedicines,
Год журнала:
2024,
Номер
12(9), С. 2030 - 2030
Опубликована: Сен. 5, 2024
Skin
aging
is
characterized
by
reactive
oxygen
species
(ROS)
accumulation,
principal
players
in
triggering
events
associated
with
aging.
Our
recent
data
on
the
ability
of
an
innovative
poly-component
formulation
(KARISMA
Rh
Collagen
Язык: Английский
The ability of the Lab4 probiotic consortium to impact upon the functionality of serum deprived human keratinocytes in vitro
Frontiers in Microbiomes,
Год журнала:
2024,
Номер
3
Опубликована: Ноя. 19, 2024
Introduction
Dysfunction
of
keratinocytes
contributes
to
a
weakened
skin
barrier
and
impaired
wound
healing
capability.
Evidence
suggests
that
probiotic
supplementation
can
lead
improved
function
in
vitro
vivo.
The
Lab4
consortium
comprises
two
strains
Lactobacillus
species
Bifidobacterium
species.
Methods
Using
serum
deprived
conditions
impair
the
functionality
immortalized
human
HaCaT
keratinocytes,
this
study
aimed
assess
impact
metabolites
derived
from
on
keratinocyte
function.
Results
A
significant
improvement
metabolic
activity
lower
apoptotic
was
observed
tandem
with
reduction
Caspase-3
gene
expression
Bax/Bcl2
ratio
following
addition
Lab4.
also
supported
integrity
which
better
maintained
increase
Filaggrin
expression.
In
damaged
enhanced
rates
re-epithelialization,
were
associated
significantly
increased
MMP-1
secretion
IL-6
IL-8.
Discussion
These
results
suggest
may
have
ability
benefit
skin.
Язык: Английский