Pre-injection of exosomes can significantly suppress ovarian cancer growth by activating the immune system in mice

Cancer Immunology Immunotherapy, Год журнала: 2025, Номер 74(3)

Опубликована: Фев. 4, 2025

As a type of "cold tumor" with limited immune cell infiltration, ovarian cancer has historically shown efficacy in immunotherapy. In this study, we report that exosomes from can specifically target omentum which is the predilection site for to metastasize and combat subsequently implanted tumor. Furthermore, found substantial increase proportion CD3 + T cells, particularly CD8 within omental tissue where homed. This was accompanied by significant enhancement granzyme B levels cells. Additionally, there notable elevation concentration interferon-gamma (IFN-γ) peripheral blood. vitro results indicated could be internalized dendritic cells (DCs), promote DC differentiation, induce production IFN-γ Surprisingly, also observed high expression programmed death ligand 1 (PD-L1) omentum. Therefore, discovered whether combining PD-L1 blockade led further tumor regression. However, although combination group showed complete regression, difference did not reach statistical significance. But general, emphasize case pre-injection, have great potential famous tumor", cancer, via targeting activating anti-tumor immunity, offering novel avenue overcoming cancer.

Язык: Английский

Exosome-based approaches in cancer along with unlocking new insights into regeneration of cancer-prone tissues

Regenerative Therapy, Год журнала: 2025, Номер 29, С. 202 - 216

Опубликована: Март 28, 2025

Язык: Английский