Biomolecules, Год журнала: 2025, Номер 15(3), С. 369 - 369
Опубликована: Март 4, 2025
Identifying reliable biomarkers in peripheral blood is critical for advancing the diagnosis and management of multiple sclerosis (MS), particularly given invasive nature cerebrospinal fluid (CSF) sampling. This review explores role B cells immunoglobulins (Igs), IgG IgM, as MS. cell oligoclonal bands (OCBs) CSF are well-established diagnostic tools, yet remain underdeveloped. Emerging evidence highlights structural functional variations immunoglobulin that may correlate with disease activity progression. A recent novel discovery aggregates MS patients fail to bind Protein reveals promising potential confirms previous findings unique features G link between superantigen These aggregates, enriched IgG1 IgG3 subclasses, exhibit properties, including mutations framework region 3 (FR3) IGHV3 genes, associated complement-dependent neuronal apoptosis. Data based on ELISA have demonstrated plasma can distinguish from healthy controls other central nervous system (CNS) disorders high accuracy differentiate subtypes. suggests a non-invasive monitoring.
Язык: Английский