Molecular Signaling Pathways of Quercetin in Alzheimer’s Disease: A Promising Arena DOI Creative Commons
Mansour Alsaleem, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

и другие.

Cellular and Molecular Neurobiology, Год журнала: 2024, Номер 45(1)

Опубликована: Дек. 24, 2024

Abstract Alzheimer’s disease (AD) is a neurodegenerative characterized by cognitive impairment and memory deficit. Even with extensive research studies, presently, there no effective treatment for the management of AD. Besides, most drugs used in AD did not avert neuropathology, still progressive status. For example, acetyl cholinesterase inhibitors are associated many adverse effects, such as insomnia nightmares. As well, acetylcholinesterase augment cholinergic neurotransmission leading to development effects related high acetylcholine level, salivation, rhinorrhea, vomiting, loss appetite, seizure. Furthermore, tacrine has poor bioavailability causes hepatotoxicity. These commonly do manage original those reasons, natural products were repurposed diseases. It been shown that phytochemicals produce neuroprotective against progression diseases different mechanisms, including antioxidant anti-inflammatory effects. Quercetin (QCN) reported exert an effect other lessening oxidative stress. In this review, electronic databases PubMed, Scopus, Web Science searched possible relevant studies article linking QCN on Findings from review highlighted mechanistic signaling pathways regarding Nevertheless, precise molecular mechanism was completely clarified. Consequently, aims discuss

Язык: Английский

Multifaceted roles of IL-17 in bone and tendon health DOI
Jianlin Shen, Yihuang Chen,

Y.H. Zhang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 294, С. 139498 - 139498

Опубликована: Янв. 5, 2025

Язык: Английский

Процитировано

1
Molecular Signaling Pathways of Quercetin in Alzheimer’s Disease: A Promising Arena DOI Creative Commons
Mansour Alsaleem, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

и другие.

Cellular and Molecular Neurobiology, Год журнала: 2024, Номер 45(1)

Опубликована: Дек. 24, 2024

Abstract Alzheimer’s disease (AD) is a neurodegenerative characterized by cognitive impairment and memory deficit. Even with extensive research studies, presently, there no effective treatment for the management of AD. Besides, most drugs used in AD did not avert neuropathology, still progressive status. For example, acetyl cholinesterase inhibitors are associated many adverse effects, such as insomnia nightmares. As well, acetylcholinesterase augment cholinergic neurotransmission leading to development effects related high acetylcholine level, salivation, rhinorrhea, vomiting, loss appetite, seizure. Furthermore, tacrine has poor bioavailability causes hepatotoxicity. These commonly do manage original those reasons, natural products were repurposed diseases. It been shown that phytochemicals produce neuroprotective against progression diseases different mechanisms, including antioxidant anti-inflammatory effects. Quercetin (QCN) reported exert an effect other lessening oxidative stress. In this review, electronic databases PubMed, Scopus, Web Science searched possible relevant studies article linking QCN on Findings from review highlighted mechanistic signaling pathways regarding Nevertheless, precise molecular mechanism was completely clarified. Consequently, aims discuss

Язык: Английский

Процитировано

0