Targeting Atherosclerosis via NEDD4L Signaling—A Review of the Current Literature

Biology, Год журнала: 2025, Номер 14(3), С. 220 - 220

Опубликована: Фев. 20, 2025

Cardiovascular diseases are the primary cause of mortality worldwide. In this scenario, atherosclerotic cardiovascular outcomes dominate since their incidence increases as populations grow and age. Atherosclerosis is a chronic inflammatory disease that affects arteries. Although its pathophysiology heterogeneous, some genes indissociably associated with occurrence, understanding effects on disease’s occurrence could undoubtedly define effective screening treatment strategies. One such gene NEDD4L. The NEDD4L related to ubiquitin ligase enzyme activities. It essential regulate vascular inflammation, atherosclerosis plaque stability, endothelial smooth cell function, lipid metabolism, particularly in controlling cholesterol levels. However, evidence dubious, no review has yet synthesized targeting atherosclerosis. Therefore, our aims fill gap by analyzing literature concerning occurrence. To achieve goal, we performed systematic search reputable databases, including PubMed, Google Scholar, Web Science, Scopus, Embase. inclusion criteria comprised peer-reviewed original studies using vitro animal models due unavailability relevant clinical studies. Systematic reviews, meta-analyses, articles did not focus relationship between those unrelated health condition were excluded. Studies written English language also strategy included from January 2000 2025 final analysis capture recent advancements. Following screening, five included. Most underscored NEDD4L’s role increasing formation, but other indicated stimulating may positively counter formation. future research endeavors must address several limitations, which have been tentatively highlighted throughout manuscript, for more informative based preclinical successfully translate findings into trials.

Язык: Английский

The role of programmed cell death in diabetes mellitus-induced erectile dysfunction: from mechanisms to targeted therapy

Reproductive Biology and Endocrinology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 3, 2025

Язык: Английский