Stability Dynamics of Plant-Based Extracellular Vesicles Drug Delivery DOI Creative Commons
Saurabh Rawat, Sanchit Arora,

Madhukiran R. Dhondale

и другие.

Journal of Xenobiotics, Год журнала: 2025, Номер 15(2), С. 55 - 55

Опубликована: Апрель 13, 2025

Plant-based extracellular vesicles (PBEVs) have been recognized for their wide range of applications in drug delivery however, the extent medicinal applicability depends on how well they are preserved and stored. Assessing physicochemical properties, such as size, particle concentration, shape, activity cargo, forms foundation determining stability during storage. Moreover, evaluation PBEVs is essential to ensure both safety efficacy, which critical advancing clinical development. Maintaining biological EVs storage a challenging task, similar preservation cells other cell-derived products like proteins. However, despite limited studies, it expected that storing drug-loaded may present fewer challenges compared cell-based therapies, although some limitations inevitable. This article provides comprehensive overview current knowledge methods, particularly focusing role carriers. hold promise potential candidates oral administration due effective intestinal absorption ability withstand basic acidic environments. maintaining critical. this review centers isolation, characterization, PBEVs, exploring advantages offer. Furthermore, highlights key areas require further research overcome existing enhance development methods therapeutic EVs.

Язык: Английский

Stability Dynamics of Plant-Based Extracellular Vesicles Drug Delivery DOI Creative Commons
Saurabh Rawat, Sanchit Arora,

Madhukiran R. Dhondale

и другие.

Journal of Xenobiotics, Год журнала: 2025, Номер 15(2), С. 55 - 55

Опубликована: Апрель 13, 2025

Plant-based extracellular vesicles (PBEVs) have been recognized for their wide range of applications in drug delivery however, the extent medicinal applicability depends on how well they are preserved and stored. Assessing physicochemical properties, such as size, particle concentration, shape, activity cargo, forms foundation determining stability during storage. Moreover, evaluation PBEVs is essential to ensure both safety efficacy, which critical advancing clinical development. Maintaining biological EVs storage a challenging task, similar preservation cells other cell-derived products like proteins. However, despite limited studies, it expected that storing drug-loaded may present fewer challenges compared cell-based therapies, although some limitations inevitable. This article provides comprehensive overview current knowledge methods, particularly focusing role carriers. hold promise potential candidates oral administration due effective intestinal absorption ability withstand basic acidic environments. maintaining critical. this review centers isolation, characterization, PBEVs, exploring advantages offer. Furthermore, highlights key areas require further research overcome existing enhance development methods therapeutic EVs.

Язык: Английский

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