Association between obstructive sleep apnea and visceral adiposity index and lipid accumulation product: NHANES 2015–2018

Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)

Опубликована: Апрель 10, 2024

Obesity refers to a significant contributor the development of obstructive sleep apnea (OSA). Early prediction OSA usually leads better treatment outcomes, and this study aims employ novel metabolic markers, visceral adiposity index (VAI), lipid accumulation product (LAP) evaluate relationship OSA.

Язык: Английский

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Investigating the Relationship between Obstructive Sleep Apnoea, Inflammation and Cardio-Metabolic Diseases

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(7), С. 6807 - 6807

Опубликована: Апрель 6, 2023

Obstructive sleep apnoea (OSA) is a prevalent underdiagnosed disorder whose incidence increases with age and weight. Uniquely characterised by frequent breathing interruptions during sleep-known as intermittent hypoxia (IH)-OSA disrupts the circadian rhythm. Patients OSA have repeated episodes of reoxygenation, leading to systemic consequences. consequences range from apparent symptoms like excessive daytime sleepiness, neurocognitive deterioration decreased quality life pathological complications elevated biomarkers linked endocrine-metabolic cardiovascular changes. well-recognized risk factor for cerebrovascular diseases. Furthermore, other conditions that worsen outcomes, such obesity. The relationship between obesity complex reciprocal, involving interaction biological lifestyle factors. pathogenesis both involve oxidative stress, inflammation metabolic dysregulation. current medical practice uses continuous positive airway pressure (CPAP) gold standard tool manage OSA. It has been shown improve cardiac function, reduce normalise biomarkers. Nonetheless, full understanding factors involved in deleterious effects best methods eliminate their occurrence are still poorly understood. In this review, we present evidence linking increased conditions.

Язык: Английский

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Metabolic Crossroads: Unveiling the Complex Interactions between Obstructive Sleep Apnoea and Metabolic Syndrome

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(6), С. 3243 - 3243

Опубликована: Март 13, 2024

Obstructive sleep apnoea (OSA) and components of metabolic syndrome (MetS) are inextricably connected. Considering the increasing burden MetS OSA, in present review, we aimed to collate summarise potential pathophysiological mechanisms linking these pathologies. In short, obesity appears promote OSA development via multiple pathways, some which not directly related mass but rather complications obesity. Simultaneously, promotes weight gain through central mechanisms. On other hand, diabetes mellitus contributes pathophysiology mainly effects on peripheral nerves carotid body desensitization, while intermittent hypoxia fragmentation principal culprits OSA-mediated diabetes. Apart from a bidirectional relationship, together additively increase cardiovascular risk patients. Additionally, emergence new drugs targeting unequivocal results available studies underscore need for further exploration all with aim improving outcomes

Язык: Английский

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Association between triglyceride glucose-body mass index and obstructive sleep apnea: a study from NHANES 2015–2018

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Авг. 16, 2024

Background The association between TyG-BMI index and the risk of obstructive sleep apnea (OSA), a recently identified biomarker indicating insulin resistance, has yet to be elucidated. Therefore, this study aimed investigate OSA using NHANES database. Methods Analyses were performed on data conducted 2015 2018. Logistic regression, stratified analyses, curve-fitting threshold effects analyses utilized assess OSA. Results included 4,588 participants. Multifactorial logistic regression found significant increased [OR: 1.54 (CI:1.39–1.70)]. In age interacted with association, being associated only in subgroup subjects younger than 60 years [1.31 (1.14–1.50)], but gender, smoking status, alcohol use, did not influence association. presence diabetes, hypertension, cardiovascular diseases also modified number such conditions was significantly lower, therefore significance associations observed those subgroups. Additionally, non-linearly associated, inflection point at 12.09, after which lower slope observed. Conclusion This demonstrates that elevated levels are correlated for OSA, underscoring these findings facilitating early prevention or timely intervention

Язык: Английский

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Therapeutic Potential of Glucagon-like Peptide-1 Receptor Agonists in Obstructive Sleep Apnea Syndrome Management: A Narrative Review

Diseases, Год журнала: 2024, Номер 12(9), С. 224 - 224

Опубликована: Сен. 23, 2024

Obstructive Sleep Apnea (OSA) is a prevalent disorder characterized by repetitive upper airway obstructions during sleep, leading to intermittent hypoxia and sleep fragmentation. Current treatments, particularly Continuous Positive Airway Pressure (CPAP), face adherence challenges, necessitating novel therapeutic approaches.

Язык: Английский

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The Role of the Circadian Rhythm in Dyslipidaemia and Vascular Inflammation Leading to Atherosclerosis

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(18), С. 14145 - 14145

Опубликована: Сен. 15, 2023

Cardiovascular diseases (CVD) are among the leading causes of death worldwide. Many lines evidence suggest that disturbances in circadian rhythm responsible for development CVDs; however, misalignment is not yet a treatable trait clinical practice. The controlled by central clock located suprachiasmatic nucleus and genes (molecular clock) all cells. Dyslipidaemia vascular inflammation two hallmarks atherosclerosis numerous experimental studies conclude they under direct influence both molecular clocks. This review will summarise results on lipid metabolism, rhythm, translate them into pathophysiology cardiovascular disease. We discuss effect time-respected administration medications medicine. bright light melatonin health, metabolism inflammation. Finally, we an agenda future research recommend

Язык: Английский

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Biological sex‐related differences in the postprandial triglyceride response to intermittent hypoxaemia in young adults: a randomized crossover trial

The Journal of Physiology, Год журнала: 2024, Номер unknown

Опубликована: Янв. 29, 2024

Abstract Obstructive sleep apnoea is characterized by chronic intermittent hypoxaemia and independently associated with an increased risk of metabolic comorbidities (e.g. type II diabetes ischaemic heart disease). These could be attributable to hypoxaemia‐induced alterations in blood lipid profiles. However, it remains unclear whether alters triglyceridaemia differently between biological sexes. Therefore, we used a randomized crossover design examine 6 h moderate (15 hypoxaemic cycles/h, 85% oxyhaemoglobin saturation) plasma triglyceride levels men women after high‐fat meal. Relative men, displayed lower total triglycerides, addition denser triglyceride‐rich lipoprotein triglycerides (TRL‐TG; mainly very low‐density chylomicron remnant triglycerides) buoyant TRL‐TG (mainly during normoxia (ambient air) (sex × time: all P ≤ 0.008). Intermittent led higher (condition: 0.016); however, this effect was observed only condition: 0.002). Compared normoxia, glucose were < 0.001). The different postprandial responses sexes occurred despite similar reductions mean saturation elevations insulin levels, non‐esterified fatty acid rate ≥ 0.185). results support growing evidence showing that impacts differently, they might help explain sex‐related discrepancies the certain hypoxaemia. image Key points key characteristic obstructive metabolism multiple tissues, resulting circulating important factor for cardiometabolic diseases. Circulating are regulated sexes, typically displaying much fasting than partly explaining why ages experience mortality rates from In study, healthy young consumed meal then exposed or ambient air. We show significantly compared leads only. us understand better living diseases disease) apnoea.

Язык: Английский

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Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and sleep disorders in US adults: NHANES 2005 to 2016

Medicine, Год журнала: 2024, Номер 103(26), С. e38748 - e38748

Опубликована: Июнь 28, 2024

NHHR (non-high-density lipoprotein cholesterol to high-density ratio) is a novel lipid parameter. However, the association between and sleep disorders remains unknown.; A cross-sectional analysis was conducted using data from National Health Nutrition Examination Survey (NHANES) 2005 2016. The explored weighted multivariate logistic regression generalized summation models. Subgroup analyses were employed verify robustness of this association. prevalence 25.83% in total 22,221 participants. Compared lowest quartile NHHR, participants top had 14% higher odds fully adjusted model (OR: 1.14, 95% CI: 1.06–1.23). After subgroup interaction tests, sex, race, marital status, education level, body mass index (BMI), person income ratio (PIR), alcohol consumption, smoking hypertension, diabetes mellitus not significantly associated with positive (P for > 0.05). positively US adults. management monitoring may have potential role improving disorders.

Язык: Английский

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Radiofrequency Coblation Inferior Turbinoplasty with Modified UPPP for the Treatment of Obstructive Sleep Apnea-Hypopnea Syndrome

Ear Nose & Throat Journal, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Objective: To compare the efficacy of surgical treatment in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) involving a standalone modified uvulopalatopharyngoplasty (mUPPP) and radiofrequency coblation inferior turbinoplasty mUPPP. Methods: In this study, retrospective analysis 79 OSAHS turbinate hypertrophy oropharyngeal obstruction undergoing was performed. According to different methods, were divided into 2 groups (Group A Group B). included 36 treated B 43 mUPPP bilateral turbinoplasty. Polysomnography (PSG), active anterior rhinomanometry, success rate, complication used assess groups. The successful result defined as 50% or greater decrease index (AHI) postoperative PSG. Results: Before surgery, there no significant differences age, gender, neck circumference, body mass index, Friedman tongue position grade, tonsil size Epworth sleepiness scale score, total nasal resistance (TNR), AHI lowest O saturation (LSaO ) between After 6 months follow-up visits, AHI, LSaO , TNR showed improvement compared A. rate 76.74% 52.78% ( P = .025). There difference (13.89% vs 23.26%, .290). Conclusion: For obstruction, appears be more effective method than alone.

Язык: Английский

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Exploring the therapeutic potential of GLP-1 receptor agonists in the management of obstructive sleep apnea: a comprehensive review

Journal of Basic and Clinical Physiology and Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Obstructive Sleep Apnea (OSA) is a prevalent sleep disorder marked by repeated episodes of partial or complete upper airway obstruction during sleep, which leads to intermittent hypoxia and fragmented sleep. These disruptions negatively impact cardiovascular health, metabolic function, overall quality life. Obesity major modifiable risk factor for OSA, as it contributes both anatomical physiological mechanisms that increase the likelihood collapse While continuous positive pressure (CPAP) therapy remains gold standard OSA treatment, its limitations - particularly issues with patient adherence underscore need alternative adjunct therapeutic options. One such option use glucagon-like peptide-1 receptor agonists (GLP-1 RAs), are widely recognized their ability reduce body weight improve health. Emerging evidence suggests GLP-1 RAs may offer benefits in managing addressing obesity, key contributor condition. This narrative review seeks explore role treatment evaluating efficacy reducing severity discussing broader clinical implications future research practice.

Язык: Английский

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