Targeting metabolic reprogramming in glioblastoma as a new strategy to overcome therapy resistance DOI Creative Commons
Simona D’Aprile, Simona Denaro,

Anna Gervasi

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Фев. 26, 2025

Glioblastoma (GBM) is one of the deadliest tumors due to its high aggressiveness and resistance standard therapies, resulting in a dismal prognosis. This lethal tumor carries out metabolic reprogramming order modulate specific pathways, providing metabolites that promote GBM cells proliferation limit efficacy treatments. Indeed, remodels glucose metabolism undergoes Warburg effect, fuelling glycolysis even when oxygen available. Moreover, recent evidence revealed rewiring nucleotide, lipid iron metabolism, not only an increased growth, but also radio- chemo-resistance. Thus, while on hand advantage for GBM, other it may represent exploitable target hamper progression. Lately, number studies focused drugs targeting uncover their effects therapy resistance, demonstrating some these are effective, combination with conventional treatments, sensitizing radiotherapy chemotherapy. However, heterogeneity could lead plethora alterations among subtypes, hence treatment might be effective proneural mesenchymal ones, which more aggressive resistant approaches. review explores key mechanisms involvement highlighting how acts as double-edged sword taking into account pathways seem offer promising options GBM.

Язык: Английский

Advancing glioblastoma treatment by targeting metabolism DOI Creative Commons
Jinyi Zhao,

Xue-Mei Ma,

Peixian Gao

и другие.

Neoplasia, Год журнала: 2024, Номер 51, С. 100985 - 100985

Опубликована: Март 12, 2024

Alterations in cellular metabolism are important hallmarks of glioblastoma(GBM). Metabolic reprogramming is a critical feature as it meets the higher nutritional demand tumor cells, including proliferation, growth, and survival. Many genes, proteins, metabolites associated with GBM have been found to be aberrantly expressed, which may provide potential targets for cancer treatment. Therefore, becoming increasingly explore role internal external factors metabolic regulation order identify more precise therapeutic diagnostic markers GBM. In this review, we define characteristics GBM, investigate specificities such targetable vulnerabilities resistance, well present current efforts target improve standard care.

Язык: Английский

Процитировано

16
Glioblastoma multiforme: insights into pathogenesis, key signaling pathways, and therapeutic strategies DOI Creative Commons

Ashkan Pouyan,

Masoud Ghorbanlo,

Masoud Eslami

и другие.

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 26, 2025

Glioblastoma multiforme (GBM) is the most prevalent and aggressive primary brain tumor in adults, characterized by a poor prognosis significant resistance to existing treatments. Despite progress therapeutic strategies, median overall survival remains approximately 15 months. A hallmark of GBM its intricate molecular profile, driven disruptions multiple signaling pathways, including PI3K/AKT/mTOR, Wnt, NF-κB, TGF-β, critical growth, invasion, treatment resistance. This review examines epidemiology, mechanisms, prospects targeting these pathways GBM, highlighting recent insights into pathway interactions discovering new targets improve patient outcomes.

Язык: Английский

Процитировано

1
Targeting metabolic reprogramming in glioblastoma as a new strategy to overcome therapy resistance DOI Creative Commons
Simona D’Aprile, Simona Denaro,

Anna Gervasi

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Фев. 26, 2025

Glioblastoma (GBM) is one of the deadliest tumors due to its high aggressiveness and resistance standard therapies, resulting in a dismal prognosis. This lethal tumor carries out metabolic reprogramming order modulate specific pathways, providing metabolites that promote GBM cells proliferation limit efficacy treatments. Indeed, remodels glucose metabolism undergoes Warburg effect, fuelling glycolysis even when oxygen available. Moreover, recent evidence revealed rewiring nucleotide, lipid iron metabolism, not only an increased growth, but also radio- chemo-resistance. Thus, while on hand advantage for GBM, other it may represent exploitable target hamper progression. Lately, number studies focused drugs targeting uncover their effects therapy resistance, demonstrating some these are effective, combination with conventional treatments, sensitizing radiotherapy chemotherapy. However, heterogeneity could lead plethora alterations among subtypes, hence treatment might be effective proneural mesenchymal ones, which more aggressive resistant approaches. review explores key mechanisms involvement highlighting how acts as double-edged sword taking into account pathways seem offer promising options GBM.

Язык: Английский

Процитировано

0