Olovnikov, Telomeres, and Telomerase. Is It Possible to Prolong a Healthy Life?

Biochemistry (Moscow), Год журнала: 2023, Номер 88(11), С. 1704 - 1718

Опубликована: Ноя. 1, 2023

The science of telomeres and telomerase has made tremendous progress in recent decades. In this review, we consider it first a historical context (the Carrel-Hayflick-Olovnikov-Blackburn chain discoveries) then review current knowledge on the telomere structure dynamics norm pathology. Central to are consequences shortening, including position effects, DNA damage signaling, increased genetic instability. Cell senescence role length its development discussed separately. Therapeutic aspects risks lengthening methods use other approaches also discussed.

Язык: Английский

Olovnikov, telomeres and telomerase. is it possible to prolong a healthy life?

Биохимия, Год журнала: 2023, Номер 88(11), С. 2066 - 2083

Опубликована: Дек. 15, 2023

The science of telomeres and telomerase has made tremendous progress in recent decades. In this review, we consider it first a historical context (the Carrel-Hayflick-Olovnikov-Blackburn chain discoveries) then review current knowledge telomere structure dynamics norm pathology. Central to the are consequences shortening, including position effects, DNA damage signaling, increased genetic instability. Cell senescence role length its development discussed separately. Therapeutic aspects risks other lengthening methods also discussed.

Язык: Английский