The Extrapulmonary Clinical Manifestations among Patients with Different Grades of COVID-19 Severity DOI Open Access

Marwan N Mohamed Emad

International Journal of Science and Research (IJSR), Год журнала: 2023, Номер 12(8), С. 752 - 757

Опубликована: Авг. 5, 2023

Background: Several epidemiological studies show that COVID-19 has a multisystem disease presentation, as well respiratory condition. The correlation between the extrapulmonary manifestations and severity of addressed in few retrospective did not involve multiple systems. This study aims to identify clinical SARS-CoV-2 cases different grades severity. Methods: It is prospective observational been conducted at Assiut University hospitals. included 445 participants were diagnosed positive with based on PCR test (208 females 237 males). They categorized into four groups according illness; mild group (n=255), moderate (n=60), severe (n= 58), critical (n=29). Results: highest COVID infection rates found age 70 80 years (19.6%). Most observed range 89 (48.3%). Moreover, higher was seen males (53.3%). Smokers (32.8%) patients, had smoking (65.5% 60.3%, respectively). most encountered comorbid conditions among patients diabetes (23.8%), followed by hypertension (14.4%), ischemic heart (12.8%). common this studywere failure (14.8%), headache (57.3), smell impairment (41.3%), impaired consciousness (17.8), abdominal pain (31.3 %), nausea/vomiting (9.5%), hematuria (18.7%), albuminuria (15.7%), acute kidney injury (increase creatinine) (8.5%), leukocytosis (26.7%), thrombocytopenia (17.3%), lymphocytosis (25.7 raised C-Reactive Protein (53.9%), anemia (36%), lymphopenia ketoacidosis (8.8%) thyrotoxicosis (2.7%).Conclusion: incidence showed statistically significant difference

Язык: Английский

Thyroid dysfunction in COVID-19 DOI
David Tak Wai Lui, Chi‐Ho Lee,

Yu Cho Woo

и другие.

Nature Reviews Endocrinology, Год журнала: 2024, Номер 20(6), С. 336 - 348

Опубликована: Фев. 12, 2024

Язык: Английский

Процитировано

20

Advances in Subacute Thyroiditis: Pathogenesis, Diagnosis, and Therapies DOI
Yu‐Chuan Li, Yue Hu, Yi Zhang

и другие.

The FASEB Journal, Год журнала: 2025, Номер 39(7)

Опубликована: Апрель 9, 2025

ABSTRACT Subacute thyroiditis (SAT) is an inflammatory thyroid disease that often associated with viral infections. In particular, SARS‐COV‐2 and its vaccine were found to cause SAT during the recent COVID‐19 pandemic. However, pathogenesis, clinical features, processes still need further profiling. Recently, there are new findings understanding about pathogenic mechanisms of SAT. Some HLA genes have been shown increase risk development, cytokine storms could promote progression diagnostic criteria for proposed facilitate clinicians' diagnosis when facing atypical symptoms in a manner rapidity accuracy. Plus, treatments herbal medicines recently as addition conventional steroidal drugs NSAIDs. This review will provide summary these progresses on diagnosis, therapies emphasis role variety virus pathogens, including virus.

Язык: Английский

Процитировано

0

Comparative analysis of clinical profile, laboratory profile and outcome in COVID-19 patients with and without hypothyroidism DOI Creative Commons

Bindu Malini,

Yoganathan Chidambaram,

Christopher Paul Clement Jenil Dhas

и другие.

Ghana Medical Journal, Год журнала: 2024, Номер 58(3), С. 192 - 197

Опубликована: Сен. 30, 2024

Objectives: Previous studies suggest that patients’ thyroid status might directly impact the course of Coronavirus disease 2019 (COVID-19). The objective study was to determine clinical profile COVID-19 patients with hypothyroidism and compare it without hypothyroidism.Design: Retrospective observational studySetting: conducted in a tertiary healthcare centre Tamil Nadu between May June 2021.Participants: included 117 admitted as well age Gender matched hypothyroidism.Main outcome measures: Data regarding demography, comorbidities, presenting symptoms, method diagnosis COVID-19, computed tomography (CT) severity score, Interleukin 6 (IL-6), D-dimer, oxygen requirement, number days hospital were collected for both groups. analysis conducted, p<0.05 considered statistically significant.Results: comprised 234 over two months, from 2021. Distribution symptoms showed group presented higher incidence fever (66.67%), loose stool (18.80%) myalgia (7.69%). Results show RTPCR+, O2 Requirement, death, IL-6, CT-severity did not any significant differences (p>0.05) outcomes also groups reported four mortalities.Conclusions: results help conclude patient is associated deranged laboratory values mortality.

Язык: Английский

Процитировано

0

SARS-CoV-2 infection and thyroid dysfunction in children DOI Creative Commons
Kateryna Kozak, Halyna Pavlyshyn, Iryna Avramenko

и другие.

The Ukrainian Biochemical Journal, Год журнала: 2023, Номер 95(3), С. 12 - 21

Опубликована: Июль 10, 2023

The problem of thyroid dysfunction related to SARS-CoV-2 infection remains unclear in children. Therefore, the study aimed reveal interrelationship between and COVID-19 severity­ as well determine optimal cut-off values for screening disorders A total number 90 children aged from 1 month 17 years were involved study. Patients with known disease not recruited research. panel was assessed all participants that included: free triiodothyronine (FT3), thyroxine (FT4), thyroid-stimulating hormone (TSH) anti-thyroid peroxidase (ATPO) antibodies. Statistical analysis done using computer software Statistica 13.0. Research has revealed euthyroid sick syndrome (ESS) 14.10% infected more often among patients severe multisystem inflammatory (33.33%) compared mild course (6.67%) moderate severity (8.89%) (P < 0.05). Significant correlation relationships next – FT3 erythrocyte sedimentation rate (ESR) (rs = -0.22; P 0.05); C-reactive protein (CRP) -0.33; procalcitonin -0.43; ESS determination revealed: ESR 18.5 mm/h (AUC 0.803); CRP 11.5 mg/l 0.763); ferritin 84.8 ng/ml 0.733). Results suggest pediatricians should pay attention endocrine disruptions by Keywords: COVID-19, children, markers

Язык: Английский

Процитировано

1

Antithyroid antibody profile and viral markers in autoimmune thyroiditis in Chennai population DOI Creative Commons

V. Nagarajan,

Sarah Andrea Wilson,

Kaveri Krishansamy

и другие.

IP International Journal of Medical Microbiology and Tropical Diseases, Год журнала: 2024, Номер 9(4), С. 241 - 245

Опубликована: Янв. 15, 2024

Autoimmune thyroid disease (AITD) is the result of a complex interaction between genetic and environmental factors, which leads to failure one or more mechanisms responsible for controlling thyroid-reactive T B cells. The most frequently occurring clinical forms autoimmune thyroiditis include Hashimoto’s Grave’s disease. Viruses have been implicated in onset disorders. This study aims investigate association by assessing virologic immunologic parameters cases with indication AITD. Anti-thyroid peroxidase (TPO) Anti-thyroglobulin (TG) antibodies were evaluated using ELISA. presence Hepatitis C virus (HCV) IgG IgM RNA was investigated RT-PCR. A total sixty subjects involved this study. Sixteen male patients (26.66%) forty-four female (68.33%) positive Anti-TPO antibodies. Four (6.66%) twenty-five (41.66%) Anti-TG twenty-two (36.66%) both One patient tested HCV ELISA 3 (5%) 13 (21.66%) female. None samples RNA. We conclude that viral infection may be triggering mechanisms. Further studies larger population are necessary establish an HCV, pathogenesis

Язык: Английский

Процитировано

0

CT semi-quantitative score used as risk factor for hyponatremia in patients with COVID-19: a cross-sectional study DOI Creative Commons

Baofeng Wu,

Ru Li,

Jinxuan Hao

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Июнь 14, 2024

Purpose Chest computed tomography (CT) is used to determine the severity of COVID-19 pneumonia, and pneumonia associated with hyponatremia. This study aims explore predictive value semi-quantitative CT visual score for hyponatremia in patients provide a reference clinical practice. Methods In this cross-sectional study, 343 RT-PCR confirmed COVID-19, all underwent CT, lung lesions was scored by radiologists using score. The risk factors were analyzed combined laboratory tests. thyroid function changes caused SARS-CoV-2 infection their interaction also analyzed. Results infection, total (TSS) higher [M(range), 3.5(2.5–5.5) vs 3.0(2.0–4.5) scores, P =0.001], implying that had more severe lesions. multivariate regression model included age, vomiting, neutrophils, platelet, impacted function, showed lower free triiodothyronine (3.1 ± 0.9 3.7 0.9, =0.001) stimulating hormone level [1.4(0.8–2.4) 2.2(1.2–3.4), =0.038]. Conclusion Semi-quantitative can be as factor COVID-19. There weak positive correlation between serum sodium infection.

Язык: Английский

Процитировано

0

SARS-CoV-2 Associated Impact on Reproductive Health: A Global Perspective DOI

P.S. Kalsi,

Navita Aggarwal,

Kamla Kant Shukla

и другие.

Indian Journal of Clinical Biochemistry, Год журнала: 2024, Номер unknown

Опубликована: Июнь 21, 2024

Язык: Английский

Процитировано

0

Homoeopathic Approach in Thyroid Issues Induced by COVID 19 DOI Open Access
Tridibesh Tripathy, Shankar Das,

Anjali Tripathy

и другие.

Saudi Journal of Medicine, Год журнала: 2023, Номер 8(04), С. 178 - 181

Опубликована: Апрель 15, 2023

[3, 17]: On April 10th 2023, the 180th world homoeopathy day is to be celebrated honor birth anniversary of Dr. Samuel Hahnemann (10.4.1755- 2.7.1843), father homoeopathy. The current article a tribute his immense contribution medical science and celebrates in 2023. When patient visits doctor for any chronic physical or mental problem, invariably gets status thyroid gland patient. As evident, COVID 19 impacted as well which continues manifest problems affected patients. Cases naturally non-resolving long term hypothyroidism are rising post cases rising, it implies that modern system medicine finding its challenging deal with here Homoeopathy can play an active role. explores what offer masses while being cost effective clinically well. suggests one treatment protocol applied at state national level public sector private sector. It looks aligning Essential Drug List domain AYUSH ministry government India.

Язык: Английский

Процитировано

0

The Extrapulmonary Clinical Manifestations among Patients with Different Grades of COVID-19 Severity DOI Open Access

Marwan N Mohamed Emad

International Journal of Science and Research (IJSR), Год журнала: 2023, Номер 12(8), С. 752 - 757

Опубликована: Авг. 5, 2023

Background: Several epidemiological studies show that COVID-19 has a multisystem disease presentation, as well respiratory condition. The correlation between the extrapulmonary manifestations and severity of addressed in few retrospective did not involve multiple systems. This study aims to identify clinical SARS-CoV-2 cases different grades severity. Methods: It is prospective observational been conducted at Assiut University hospitals. included 445 participants were diagnosed positive with based on PCR test (208 females 237 males). They categorized into four groups according illness; mild group (n=255), moderate (n=60), severe (n= 58), critical (n=29). Results: highest COVID infection rates found age 70 80 years (19.6%). Most observed range 89 (48.3%). Moreover, higher was seen males (53.3%). Smokers (32.8%) patients, had smoking (65.5% 60.3%, respectively). most encountered comorbid conditions among patients diabetes (23.8%), followed by hypertension (14.4%), ischemic heart (12.8%). common this studywere failure (14.8%), headache (57.3), smell impairment (41.3%), impaired consciousness (17.8), abdominal pain (31.3 %), nausea/vomiting (9.5%), hematuria (18.7%), albuminuria (15.7%), acute kidney injury (increase creatinine) (8.5%), leukocytosis (26.7%), thrombocytopenia (17.3%), lymphocytosis (25.7 raised C-Reactive Protein (53.9%), anemia (36%), lymphopenia ketoacidosis (8.8%) thyrotoxicosis (2.7%).Conclusion: incidence showed statistically significant difference

Язык: Английский

Процитировано

0