Advances in Clinical Medicine, Год журнала: 2023, Номер 13(11), С. 17713 - 17719
Опубликована: Янв. 1, 2023
Язык: Английский
The Journal of Infection in Developing Countries, Год журнала: 2024, Номер 18(04), С. 600 - 608
Опубликована: Апрель 30, 2024
Introduction: Human Mpox (formerly monkeypox) infection is an emerging zoonotic disease caused by the virus (MPXV). We describe complete genome annotation, phylogeny, and mutational profile of a novel, sustained Clade I outbreak in city Kamituga Eastern Democratic Republic Congo (DRC). Methodology: A cross-sectional, observational, cohort study was performed among patients all ages admitted to Hospital with symptoms between late September 2023 January 2024. DNA isolated from swabbed lesions sequenced followed phylogenetic analysis, profiling. Results: ongoing Kamituga, South Kivu Province, Congo. Whole-genome sequencing viral RNA samples revealed, on average, 201.5 snps, 28 insertions, 81 deletions, 2 indels, 312.5 total variants, 158.3 amino acid changes, 81.66 intergenic 72.16 synonymous mutations, 106 missense 41.16 frameshift 3.33 inframe deletions across six samples. By assigning mutations at proteome level for MPXV sequences, we observed that seven proteins, namely, C9L (OPG047), I4L (OPG080), L6R (OPG105), A17L (OPG143), A25R (OPG151), A28L (OPG153), B21R (OPG210) have emerged as hot spot based consensuses acids substitutions. Based outcome found deletion D14L (OPG032) gene Following analysis whole assembly, determined this cluster infections genetically distinct previously reported outbreaks, thus propose represents novel subgroup (subgroup VI) MPXV. Conclusions: Here report first time. This presents oubtreaks, suggesting (we term VI). These findings underscore need vigilance continued threats endemic regions.
Язык: Английский
Процитировано
17
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Май 5, 2023
Mpox (earlier known as monkeypox) virus infection is a recognized public health emergency. There has been little research on the treatment options. This article reviews specific drugs used to treat mpox and vaccines here. Instead of focusing mechanistic basis, this review narrates practical, real-life experiences individual patients disease being administered these medicines. We conducted bibliometric analysis using data from several databases like PubMed, Scopus, Embase. The topic grown tremendously recently but it highly concentrated in few countries. Cidofovir most studied drug. because indicated also off-label for conditions. include tecovirimat, cidofovir, brincidofovir, vaccinia immune globulin, trifluridine. Tecovirimat frequently. It promising option progressive terms both efficacy safety. Brincidofovir associated with discontinuation due elevated hepatic enzymes. not preferred drug, often unavailability tecovirimat. Trifluridine topically an add-on agent along tecovirimat ocular manifestations disease. No study reports patient globulin. Though no vaccine currently approved infection, ACAM 2000 JYNNEOS are mainly considered. capable replicating may cause severe adverse reactions. when contraindicated. Several under development have discussed alongside pragmatic aspects prevention. Further studies can provide more insight into safety actively progressing
Язык: Английский
Процитировано
15
Journal of Structural Chemistry, Год журнала: 2024, Номер 65(4), С. 776 - 785
Опубликована: Апрель 1, 2024
Язык: Английский
Процитировано
4
Health Science Reports, Год журнала: 2024, Номер 7(3)
Опубликована: Март 1, 2024
Abstract Background and Aim Until the May 2022 Monkeypox (MPXV) outbreak, which spread rapidly to many non‐endemic countries, virus was considered a viral zoonosis limited some African countries. The Andalusian circuit of genomic surveillance applied characterize MPXV outbreak in South Spain. Methods Whole genome sequencing used obtain profiles samples collected across south Spain, representative all provinces Andalusia. Phylogenetic analysis study relationship isolates available sequences outbreak. Results total 160 viruses from different that reported cases were obtained. Interestingly, we report obtained two patients who died. While one bore no noteworthy mutations explain potential heightened virulence, another patient second consecutive sequence, performed after administration tecovirimat, uncovered mutation within A0A7H0DN30 gene, known be prime target for tecovirimat its Vaccinia counterpart. In general, low number observed reported, very similar reference (OX044336), as expected DNA virus. likely correspond several introductions circulating last sequenced died presented gene bears connections drug resistance. This absent initial before treatment.
Язык: Английский
Процитировано
2
Journal for Research in Applied Sciences and Biotechnology, Год журнала: 2023, Номер 2(3), С. 134 - 146
Опубликована: Июнь 21, 2023
Some issues regarding the potential spread of monkeypox have arisen just as international world is beginning to recover from initial alarm that was caused by probable coronavirus disease 2019 (COVID-19). Despite fact parts Africa traditionally been more susceptible than other regions world, majority new cases linked outbreak began in 2022 reported countries located Europe and western hemisphere. a great number organisations are working on contact-tracing activities at moment, origin this still unknown time. The virus belongs family viruses known Poxviridae genus Orthopoxvirus. Following eradication smallpox across globe 1970s, news widespread worry globe. Through vaccination with virus, individuals were able develop cross-immunity against monkeypox. After distribution vaccine discontinued, outbreaks rose. epidemic occurred United States 2003 first time gained extensive notice media. In spite its name, not transmitted monkeys. Although different kinds rodents small mammals suggested primal hosts virus's true lineage mystery. causes identified macaque monkeys, which where seen. When does transfer one person another, it often so through person's mucocutaneous lesions or respiratory droplets they expel. However, only happens very infrequently. supporting therapy can be given reduce symptoms, medications such tecovirimat may administered really severe cases. At time, there no specific treatment for patients who infected virus; however, supportive treatments given. It debatable whether these successful reducing symptoms because concrete guidelines follow regard.
Язык: Английский
Процитировано
5
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Фев. 12, 2024
Abstract Monkeypox is one of the infectious viruses which caused morbidity and mortality problems in these years. Despite its danger to public health, there no approved drug stand handle Monkeypox. On other hand, repurposing a promising screening method for low-cost introduction drugs emerging diseases utilizes computational methods. Therefore, approach suggesting monkeypox virus. This paper proposes framework antiviral prediction. To do this, we have geenrated new virus-antiviral dataset. Moreover, applied several machine learning deep The suggested by methods been investigated using docking studies. best our knowledge, this work first study prediction antivirals. results confirm that Tilorone, Valacyclovir, Ribavirin, Favipiravir, Baloxavir marboxil are effective treatment.
Язык: Английский
Процитировано
1
PLoS ONE, Год журнала: 2024, Номер 19(9), С. e0299342 - e0299342
Опубликована: Сен. 12, 2024
Monkeypox (MPXV) is one of the infectious viruses which caused morbidity and mortality problems in these years. Despite its danger to public health, there no approved drug stand handle MPXV. On other hand, repurposing a promising screening method for low-cost introduction drugs emerging diseases utilizes computational methods. Therefore, approach suggesting This paper proposes framework MPXV antiviral prediction. To do this, we have generated new virus-antiviral dataset. Moreover, applied several machine learning deep The suggested by methods been investigated using docking studies. target protein structure modeled homology modeling and, then, refined validated. best our knowledge, this work first study prediction antivirals. results confirm that Tilorone, Valacyclovir, Ribavirin, Favipiravir, Baloxavir marboxil are effective treatment.
Язык: Английский
Процитировано
1
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Дек. 19, 2024
Monkeypox, a zoonotic virus in the
Язык: Английский
Процитировано
1
CMI Communications, Год журнала: 2024, Номер unknown, С. 105042 - 105042
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
0
Reviews in Medical Microbiology, Год журнала: 2024, Номер unknown
Опубликована: Янв. 15, 2024
Human monkeypox disease (mpox) has resurfaced recently as a public health emergency of international concern in the wake coronavirus 2019 (COVID-19) pandemic, spreading endemic and nonendemic regions across globe. The purpose this concise review is to provide an overview background, cause, epidemiology, diagnosis, treatment, prevention mpox. virus (MPXV) enveloped double-stranded deoxyribonucleic acid (DNA) that belongs Orthopoxvirus genus Poxviridae family. In past, mpox been primarily zoonotic affected rural, forested areas some African countries. There no doubt changing many ways since 2022 global outbreak, particularly human-to-human transmission through sexual contact new clinical presentations. spite fact severity prevalence vary by age sex, common symptoms are present all patients. Many patients experience fever, muscle pain headache, swollen lymph nodes, skin rashes. A sign can be followed laboratory diagnostic tests such conventional PCR or real-time PCR. Although there specific treatment for mpox, it effectively managed with help antivirals, smallpox vaccine, vaccinia immune globulin.
Язык: Английский
Процитировано
0