Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Авг. 28, 2023
Introduction
The
mesial
temporal
lobe
plays
a
distinct
role
in
epileptogenesis,
and
tumors
this
part
of
the
brain
potentially
have
specific
clinical
radiological
features.
Differentiating
high-grade
from
lower-grade
or
non-neoplastic
lesions
can
be
challenging,
preventing
decision
for
early
resection
that
critical
tumors.
Methods
A
tumor
database
was
analyzed
retrospectively
to
identify
patients
with
temporomesial
We
determined
features
(age,
sex,
symptoms
leading
presentation)
as
well
neuroradiological
(tumor
location
presence
contrast
enhancement
on
initial
magnetic
resonance
imaging
(MRI))
neuropathological
findings.
Results
identified
324
39
involved
lobe.
77%
occured
males,
presented
seizures,
regardless
type
grade.
In
50
years
older,
90%
were
male
80%
had
glioblastoma
(GBM);
there
no
GBM
younger
than
years.
50%
GBMs
lacked
enhancement.
Male
sex
significantly
associated
GBM.
both
contrast-enhancing
non-enhancing
tumors,
age
older
also
Conclusion
middle-aged
tumor,
is
most
likely
diagnosis
even
when
MRI
Prolonged
diagnostic
workup
surveillance
strategies
should
avoided
may
justified
these
patients.
International Journal of Reliable and Quality E-Healthcare,
Год журнала:
2024,
Номер
13(1), С. 1 - 19
Опубликована: Июль 17, 2024
The
research
emphasizes
the
effectiveness
of
Bayesian
classification
algorithms
in
predicting
patient
visits
healthcare
settings.
examine
past
data
to
detect
intricate
patterns
admission
dynamics,
including
demographic,
clinical,
and
temporal
factors.
Through
use
principles,
prediction
models
are
able
estimate
probability
certain
demographics
occurring
at
intervals,
therefore
assisting
allocation
resources
management
operations.
Probabilities
that
have
been
estimated
used
make
choices
on
staffing,
resource
allocation,
operational
strategy.
variation
estimates
across
different
observations
improves
predictive
usefulness,
hence
strengthening
planning.
Journal of Neuropathology & Experimental Neurology,
Год журнала:
2024,
Номер
83(12), С. 1020 - 1029
Опубликована: Авг. 27, 2024
Abstract
Glioblastomas
(GBM),
the
most
common
primary
brain
tumor,
lack
accurate
prognostic
markers
and
have
a
poor
prognosis.
Our
study
was
designed
to
identify
effective
biomarkers
for
GBM
prognosis
analysis
development
of
precise
treatments.
Differentially
expressed
genes
(DEGs)
between
patients
controls
were
analyzed
from
Xena
database
GEPIA.
Based
on
screened
DEGs,
univariate
COX
LASSO
regression
performed
relevant
associated
with
Genes
highly
in
selected
construct
receiver
operating
characteristic
enrichment
constructed
groups
high
low
expression
adipocyte
enhancer-binding
protein
1
(AEBP1).
CIBERSORT,
ssGSEA
ESTIMATE
used
perform
immune
infiltration
analysis.
About
3297
DEGs
identified
using
data
database;
8
identified.
AEBP1,
which
plays
role
neuronal
differentiation
development,
positively
correlated
GBMs
infiltration;
its
cancer
is
short
overall
survival
advanced
tumor
staging.
This
suggests
that
AEBP1
could
serve
as
marker
may
better
response
immunotherapy.
Radiation Oncology Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 19, 2024
No
guidelines
exist
to
delineate
radiation
therapy
(RT)
targets
for
the
treatment
of
multiple
glioblastoma
(mGBM).
This
study
analyzes
margins
around
gross
tumor
volume
(GTV)
create
a
clinical
target
(CTV),
comparing
response
parameters
and
modalities
recurrence.
One-hundred
three
mGBM
patients
with
CTV
margin
2
cm
(GTV
+
2.0
cm)
or
1
1.0
were
retrospectively
analyzed.
All
received
total
dose
59.4-60
Gy
in
1.8-2.0
daily
fractions,
delivered
from
4
8
weeks
after
surgery,
concomitantly
temozolomide
(75
mg/m2).
Overall
survival
(OS)
progression-free
(PFS)
calculated
date
surgery
until
diagnosis
disease
progression
performed
by
magnetic
resonance
imaging
classified
as
marginal,
in-field,
distant,
site
distribution
RT
plan.
OS
CTV1
group
was
11.2
months
(95%
confidence
interval
[CI],
10.3-12.1),
9.2
CTV2
CI,
9.0-11.3).
PFS
occurred
within
8.3
7.3-9.3),
7.3
6.4-8.1).
difference
observed
between
two
groups
terms
time
distribution.
Adjusted
multivariate
Cox
risk
model,
epidermal
growth
factor
receptor
amplification
resulted
negative
prognostic
both
PFS.
In
mGBM,
use
expansion
seems
feasible
it
does
not
significantly
affect
oncological
outcomes
outcome.
Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Авг. 28, 2023
Introduction
The
mesial
temporal
lobe
plays
a
distinct
role
in
epileptogenesis,
and
tumors
this
part
of
the
brain
potentially
have
specific
clinical
radiological
features.
Differentiating
high-grade
from
lower-grade
or
non-neoplastic
lesions
can
be
challenging,
preventing
decision
for
early
resection
that
critical
tumors.
Methods
A
tumor
database
was
analyzed
retrospectively
to
identify
patients
with
temporomesial
We
determined
features
(age,
sex,
symptoms
leading
presentation)
as
well
neuroradiological
(tumor
location
presence
contrast
enhancement
on
initial
magnetic
resonance
imaging
(MRI))
neuropathological
findings.
Results
identified
324
39
involved
lobe.
77%
occured
males,
presented
seizures,
regardless
type
grade.
In
50
years
older,
90%
were
male
80%
had
glioblastoma
(GBM);
there
no
GBM
younger
than
years.
50%
GBMs
lacked
enhancement.
Male
sex
significantly
associated
GBM.
both
contrast-enhancing
non-enhancing
tumors,
age
older
also
Conclusion
middle-aged
tumor,
is
most
likely
diagnosis
even
when
MRI
Prolonged
diagnostic
workup
surveillance
strategies
should
avoided
may
justified
these
patients.
