Authorea (Authorea), Год журнала: 2023, Номер unknown
Опубликована: Окт. 9, 2023
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 722 - 722
Опубликована: Янв. 16, 2025
The COVID-19 pandemic has accelerated advances in molecular biology and virology, enabling the identification of key biomarkers to differentiate between severe mild cases. Furthermore, use artificial intelligence (AI) machine learning (ML) analyze large datasets been crucial for rapidly identifying relevant disease prognosis, including COVID-19. This approach enhances diagnostics emergency settings, allowing more accurate efficient patient management. study demonstrates how algorithms departments can identify vital prognosis an emerging using as example by analyzing clinical, epidemiological, analytical, radiological data. All consecutively admitted patients were included, than 89 variables processed Random Forest (RF) algorithm. RF model achieved highest balanced accuracy at 92.61%. most predictive mortality included procalcitonin (PCT), lactate dehydrogenase (LDH), C-reactive protein (CRP). Additionally, system highlighted significance interstitial infiltrates chest X-rays D-dimer levels. Our results demonstrate that is critical diseases, accelerating data analysis, optimizing personalized treatment, emphasizing importance PCT LDH high-risk patients.
Язык: Английский
Процитировано
0
Patient-Oriented Medicine and Pharmacy, Год журнала: 2025, Номер 3(1), С. 64 - 76
Опубликована: Март 26, 2025
Relevance . The Coronavirus 2019 (COVID-19) pandemic has affected all countries of the world and renewed attention to timely prevention viral infections through specific immunization general population. However, some issues related safety vaccine administration production autoantibodies after remain unclear. Objective. To evaluate dynamics formation a immune response SARS-CoV-2 virus, autoantibody interrelationships between them during vaccination with Gam-COVID-Vac (Sputnik V) in healthy young adults. Material methods retrospective study included 45 practically students who were fully vaccinated two components at university medical center made 3 follow-up visits center. There 32 females (71.0%) 13 males (29.0%) aged 19 28 years, median age 23.00 [22.00;24.00] years. All trainees analyzed for IgG IgM antibodies serum by enzyme-linked immunosorbent assay (ELISA) using SARS-CoV-2-IgG-IgG-IFA-BEST SARS-CoV-2-IgM-IFA-BEST test systems, as well double-helix deoxyribonucleic acid (anti-dsDNA) kits (Vecto-dsDNA-IgG) Vector-Best JSC (Russia). concentration cardiolipin (IgM aCL, aCL) ELISA method (kits ORGenTec Diagnostika, Germany) was investigated three times 29 patients. Statistical processing results performed generally accepted parametric nonparametric analysis. Results. In examined individuals before Gam-COVID-Vac, levels low within reference values. After first component vaccine, level increased significantly compared period (KP: 0.28 [0.17;1.25] u.u. 0.07 [0.04;0.09] u.u., respectively, p <0.001). It remained high, baseline, stage 2 0.13 [0.07;0.37] <0.001), but underwent significant decrease second component, data 1 (p <0.01). vaccination, KP exceeded values 1.1 cfu 14 (31.11%) individuals, decreased 11.11% stage. baseline period, there dramatic increase both (KP:10.24 [6.78;12.44] 0.06 [0.05;0.11] <0.001) occurrence their high detection rate greater than u.u.) 91.11%, it reached 100.0%. higher found men women (KP 12.44 [10.24;15.78] 9.75 [4.50;11.95] women, aCL (1.41 [1.02;1.62] GPL U/mL 1.00 [0.87;1.32] U/mL, <0.05) trend toward anti-dsDNA concentrations >0.05) those opposite sex. not different >0.05). step, almost differences initial one (p=0.05). increased, reaching second-stage (1.37 [1.02;1.51] [0.81;1.40] <0.05). Only detected titer or drug. any case. Conclusions. age, antiviral is effectively formed when Gam-COVID Vac. more pronounced especially associated certain types characteristic immunoinflammatory rheumatic diseases. cases induction synthesis, transient.
Язык: Английский
Процитировано
0
Journal of Medical Virology, Год журнала: 2024, Номер 96(4)
Опубликована: Апрель 1, 2024
Язык: Английский
Процитировано
1
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Окт. 18, 2024
While Coronavirus disease 2019 (COVID-19) vaccines have proven to be both effective and generally safe, rare but severe adverse events following immunization (AEFIs) are described. Autoantibodies platelet factor-4 associated with catastrophic thrombotic AEFIs, comprehensive investigations of other autoantibodies lacking. We aimed detect describe targeting coagulation-related proteins in a population-wide cohort (SWEDEGENE) including AEFIs attributed COVID-19 Sweden. Subjects were recruited from December 2020 October 2022 stratified based on diagnosis exposure. Screening was carried out two phases, multiplex bead-based assay the first subset (until September 2021) targeted assays for second 2022). Positivity defined absolute, relative, biological/technical thresholds. Patients older Vaxzevria vaccine overrepresented this group. Two cases had antiphospholipid antibodies none PF4 antibodies. identified six positives protein S autoantibodies. Protein concentrations negatively correlated autoantibody response patients immunoreactivity functional analysis revealed low activity three subjects. Our reveals against which possibly underlie coagulopathic AEFIs.
Язык: Английский
Процитировано
1
Autoimmunity Reviews, Год журнала: 2024, Номер unknown, С. 103698 - 103698
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
1
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Ноя. 22, 2023
Abstract Adverse hematologic events have been reported after COVID-19 vaccination. The objective of this study was to investigate whether abnormalities develop Retrospective cohort analyses data from the Korean National Health Insurance Service (KNHIS) database were conducted July 2022 August 2023. We randomly selected half those living in Seoul City as January 1, 2021 with their diagnostic records up December 31, 2021. included participants vaccinated and nonvaccinated persons aged 20 years or older (n= 4,203,887). Hematologic vaccination identified nutritional anemia, hemolytic aplastic coagulation defects, neutropenia using International Classification Diseases, Tenth Revision codes index date. Incidence rates group 3 months significantly higher than group: 14.79 vs. 9.59 (P<.001) for 7.83 5.00 4.85 1.85 defects. mRNA vaccine associated development anemia (odds ratio [OR], 1.230 [95% CI, 1.129-1.339], P<.001) (OR, 1.242 1.110-1.390], viral vector vaccine. risk defects increased 1.986 1.523-2.589], vaccination, there no difference between 1.075 0.936-1.233], P=.306). In conclusions, abnormalities. When administering vaccine, careful observation will be necessary
Язык: Английский
Процитировано
2
Authorea (Authorea), Год журнала: 2023, Номер unknown
Опубликована: Окт. 9, 2023
Язык: Английский
Процитировано
0