Dedifferentiated Leiomyosarcoma of the Uterine Corpus with Heterologous Component: Clinicopathological Analysis of Five Consecutive Cases from a Single Institution and Comprehensive Literature Review

Diagnostics, Год журнала: 2024, Номер 14(2), С. 160 - 160

Опубликована: Янв. 10, 2024

Dedifferentiation is a very rare phenomenon in uterine leiomyosarcoma (LMS). The aim of this study was to comprehensively analyze the clinicopathological characteristics dedifferentiated LMS (DDLMS). We reviewed electronic medical records and pathology slides from five patients with DDLMS performed immunostaining. mean age 56 years. Two presented abdominal discomfort, while three cases tumors were detected on routine examination. size 17.0 cm. Four underwent hysterectomy. initial stages distributed as IB (2/5), IIIC IVC (1/5). Post-operative concurrent chemoradiation therapy, radiation chemotherapy administered one, two patients, respectively. Despite post-operative treatment, developed metastatic recurrences pelvic organs. Recurrence-free survival time ranged between 4 30 months. Histologically, differentiated areas demonstrated classic morphology malignant smooth muscle differentiation, whereas resembled undifferentiated pleomorphic sarcoma characterized by large tumor cells admixed haphazardly arranged atypical marked nuclear pleomorphism. All also exhibited heterologous components, including chondrosarcoma (CSA; 3/5) rhabdomyosarcoma (2/5). In cases, components initially primary tumors. did not exhibit any or components. Instead, more than half recurrent consisted Three showed sharp demarcation CSA area imperceptibly merged component. Immunostaining revealed that lack desmin immunoreactivity four examined cases. A subset represents various amounts types dedifferentiation both Routine recognition distinction its mimickers are required for accurate diagnosis further characterization these

Язык: Английский

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Ovarian Metastasis from Human Papillomavirus-associated Usual-type Endocervical Adenocarcinoma: Clinicopathological Characteristics for Distinguishing from Primary Ovarian Mucinous or Endometrioid Tumor

In Vivo, Год журнала: 2024, Номер 38(4), С. 1973 - 1983

Опубликована: Янв. 1, 2024

Background/Aim: Distinguishing ovarian metastasis of usual-type endocervical adenocarcinoma (UEA) from primary tumors is often challenging because several overlapping features. This study aimed to investigate the clinicopathological characteristics and outcomes patients with metastatic UEA. Patients Methods: Clinicopathological information was collected eight Immunostaining also performed. Results: Most presented adnexal masses that were suspected be tumors. All examined cases showed block p16 positivity in paired Five who completed post-operative chemotherapy or concurrent chemoradiotherapy (CCRT) did not experience recurrence. In contrast, one patient refused further treatment after first CCRT cycle experienced peritoneal metastases. One isolated left untreated developed during follow-up. Conclusion: UEA received proper management for metastases favorable outcomes. Given can mimic borderline tumor carcinoma mucinous endometrioid type, pathologists should aware this unusual but distinctive morphology avoid misdiagnosis inappropriate treatment.

Язык: Английский

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Endocervical Adenocarcinoma Showing Microcystic, Elongated, and Fragmented (MELF) Pattern of Stromal Invasion: A Single-Institutional Analysis of 10 Cases with Comprehensive Clinicopathological Analyses and Ki-67 Immunostaining

Biomedicines, Год журнала: 2023, Номер 11(11), С. 3026 - 3026

Опубликована: Ноя. 11, 2023

Microcystic, elongated, and fragmented (MELF) pattern of invasion has seldom been documented in endocervical adenocarcinoma (EAC). The aim this study was to analyze the clinicopathological characteristics EAC showing MELF pattern. We collected information 10 cases with conducted polymer-based immunostaining for Ki-67 (dilution 1:200, clone MIB-1) on these cases. expression assessed using average estimation within hotspot method. All tumors were human papillomavirus-associated Silva C. except one tumor exceeded 3 cm size. Five involved entire thickness cervical stroma, four extended into parametrium. Lymphovascular space identified six Two patients developed metastatic recurrences para-aortic lymph nodes lungs, respectively. area showed significantly lower labelling index than that a conventional area. confirmed our previous observation displayed proliferative activity EAC. also demonstrated had several adverse reflecting aggressive behavior. On other hand, since frequencies post-operative recurrence disease-related mortality occurred during follow-up period relatively low, further investigations are warranted clarify prognostic value patients.

Язык: Английский

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Lymphangioleiomyomatosis of the Pelvic Lymph Nodes Detected Incidentally During Surgical Staging of Gynecological Malignancies: Comprehensive Clinicopathological Analysis of 17 Consecutive Cases from a Single Institution

In Vivo, Год журнала: 2024, Номер 39(1), С. 325 - 334

Опубликована: Дек. 31, 2024

Background/Aim: Lymphangioleiomyomatosis (LAM) belongs to the perivascular epithelioid cell tumor (PEComa) family. The relationship between LAM and tuberous sclerosis complex (TSC) is of particular concern in a subset women with clinically occult involving pelvic lymph nodes. This study aimed investigate clinicopathological features incidental nodal detected during surgical staging gynecological tumors. Patients Methods: During period 10 years, we identified 17 patients that was incidentally surgery for neoplastic lesions. We conducted immunostaining assess diagnostic utility panel PEComa markers. Results: Two (11.8%) were diagnosed TSC before without any pulmonary symptoms. follow-up, both developed extrapulmonary LAMs. All affected nodes multiple unilateral region. mean size 5.4 mm, proportion area involved 34.1%. In two TSC, largest node measured 19.3 mm 7.6 respectively, replaced by 99% 90%, respectively. most frequently expressed markers human melanoma black 45 cathepsin K, which showed 100% positivity all examined cases. Conclusion: While small LAMs discovered have insignificant prognostic value, larger occupying parenchyma at reproductive age should raise awareness as well TSC.

Язык: Английский

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Clinicopathological Significance of Claudin-6 Immunoreactivity in Low-grade, Early-stage Endometrioid Endometrial Carcinoma

In Vivo, Год журнала: 2024, Номер 39(1), С. 367 - 374

Опубликована: Дек. 31, 2024

Dysregulation of claudin 6 (CLDN6) expression has been widely documented in various malignancies. CLDN6 is aberrantly expressed many types human carcinomas; however, its clinical significance endometrial carcinoma seldom investigated. This study aimed to examine the immunohistochemical status low-grade, early-stage endometrioid (LGES-EEC) and assess clinicopathological significance.

Язык: Английский

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