Опубликована: Янв. 1, 2024
Язык: Английский
Cancers, Год журнала: 2025, Номер 17(3), С. 406 - 406
Опубликована: Янв. 26, 2025
Invariant Natural Killer T (iNKT) cells are a unique subset of that bridge innate and adaptive immunity, displaying potent anti-tumor properties through cytokine secretion, direct cytotoxicity, recruitment immune effector such as CD8+ NK cells. Despite their therapeutic potential, the immunosuppressive tumor microenvironment (TME), characterized by regulatory cells, myeloid-derived suppressor (MDSCs), tumor-associated macrophages (TAMs), limits iNKT cell efficacy. Patient-derived organoid (PDO) platforms provide an innovative model for dissecting these complex interactions evaluating strategies to reinvigorate functionality within TME. PDOs closely mimic genetic, phenotypic, structural characteristics primary tumors, enabling study tumor–immune dynamics. Integrating into offers robust platform investigating CD1d-mediated interactions, Th1-biased responses driven glycolipid analogs like α-GalCer, combination therapies checkpoint inhibitors. Additionally, PDO systems can assess effects metabolic modulation, including reducing lactic acid accumulation or targeting glutamine pathways, on enhancing activity. Emerging innovations, organoid-on-a-chip systems, CRISPR-Cas9 gene editing, multi-omics approaches, further expand potential PDO–iNKT personalized immunotherapy research. Although application in is still undeveloped, hold immense promise bridging preclinical studies clinical translation. By addressing challenges TME optimizing strategies, offer transformative avenue advancing cancer medicine.
Язык: Английский
Процитировано
0
PLoS Genetics, Год журнала: 2025, Номер 21(3), С. e1011652 - e1011652
Опубликована: Март 31, 2025
Prostate cancer (PC) is the most frequently diagnosed malignancy among men and contributes significantly to cancer-related mortality. While recent advances in vitro PC modeling systems have been made, there remains a lack of robust preclinical models that faithfully recapitulate genetic phenotypic characteristics across various subtypes—from localized (LPC) castration-resistant (CRPC)—along with associated stromal cells. Here, we established human assembloids from LPC CRPC tissue by reconstituting tumor organoids corresponding cancer-associated fibroblasts (CAFs), thereby incorporating aspects microenvironment (TME). Established exhibited high concordance genomic landscape parental tumors, showed higher degree similarity tumors compared without CAFs. displayed increased proliferation reduced sensitivity anti-cancer treatments, indicating are potent tools for understanding biology, investigating interaction between CAFs, identifying personalized therapeutic targets.
Язык: Английский
Процитировано
0
Life, Год журнала: 2024, Номер 14(9), С. 1094 - 1094
Опубликована: Авг. 30, 2024
Prostate cancer (PCa) is the third highest cause of death in men. PCa a very heterogeneous tumor form terms grade, phenotypes, and genetics, often accompanied by complex networks. characterized slow growth that does not compromise patient's quality life, unlike more aggressive forms showing rapid progression. Early diagnosis, even for most forms, increases possibilities cure with less treatments fewer side effects. However, it important to know how decrease exposure modifiable risk factors, including diet, sedentary smoking alcohol, can represent an effective tool reduce incidence PCa. In addition, chronic environmental which act as endocrine disruptors, focus recent studies their potential role promoting onset progression Although molecular therapies clinical trials biomarker identification have been introduced into management PCa, these still lag behind research performed other solid tumors. This review provides overview factors linked lifestyle pollutants, together development new therapeutic targets, improve life patients.
Язык: Английский
Процитировано
2
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0