Investigating the biology of microRNA links to ALDH1A1 reveals candidates for preclinical testing in acute myeloid leukemia DOI Creative Commons
Spiros Vlahopoulos, Lokman Varışlı,

Panagiotis Zoumpourlis

и другие.

International Journal of Oncology, Год журнала: 2024, Номер 65(6)

Опубликована: Окт. 30, 2024

Aldehyde dehydrogenase 1 family member A1 (ALDH1A1) is a of the aldehyde gene subfamily that encode enzymes with ability to oxidize retinaldehyde. It was recently shown high ALDH1A1 RNA abundance correlates poor prognosis in acute myeloid leukemia (AML). AML hematopoietic malignancy associated morbidity and mortality rates. Although there are number agents inhibit ALDH activity, it would be crucial develop methodologies for adjustable genetic interference, which permit interventions on several oncogenic pathways parallel. Intervention multiple theoretically possible microRNAs (miRNAs or miRs), class small non‑coding RNAs have emerged as key regulators expression AML. A miRNAs interfere directly solid tumor cells, these can evaluated model systems. There indications few actually do an association disease course, rendering them promising target intervention cells.

Язык: Английский

Investigating the biology of microRNA links to ALDH1A1 reveals candidates for preclinical testing in acute myeloid leukemia DOI Creative Commons
Spiros Vlahopoulos, Lokman Varışlı,

Panagiotis Zoumpourlis

и другие.

International Journal of Oncology, Год журнала: 2024, Номер 65(6)

Опубликована: Окт. 30, 2024

Aldehyde dehydrogenase 1 family member A1 (ALDH1A1) is a of the aldehyde gene subfamily that encode enzymes with ability to oxidize retinaldehyde. It was recently shown high ALDH1A1 RNA abundance correlates poor prognosis in acute myeloid leukemia (AML). AML hematopoietic malignancy associated morbidity and mortality rates. Although there are number agents inhibit ALDH activity, it would be crucial develop methodologies for adjustable genetic interference, which permit interventions on several oncogenic pathways parallel. Intervention multiple theoretically possible microRNAs (miRNAs or miRs), class small non‑coding RNAs have emerged as key regulators expression AML. A miRNAs interfere directly solid tumor cells, these can evaluated model systems. There indications few actually do an association disease course, rendering them promising target intervention cells.

Язык: Английский

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