Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 453 - 482
Опубликована: Дек. 13, 2024
Gastrointestinal
tract
harbours
a
very
complex
and
dynamic
community
of
microorganisms
known
as
the
'gut
microbiota'.
These
microbes
are
involved
in
various
critical
physiological
processes,
including
digestion
biomolecules,
synthesis
vitamins,
modulation
immune
system,
protection
against
pathogens.
This
chapter
provides
comprehensive
overview
gut
brain
axis.
The
delves
into
role
microbial
metabolites
like
short
chain
fatty
acids,
tryptophan
bile
acids
neuronal
neurotransmitter
functioning.
Cytokine
release
system
activation
can
potentially
change
microbiota
composition.
psychological
stress
reducing
beneficial
bacteria
increasing
pathogenic
composition
has
been
detailed.
Psychological
lead
to
these
consequences
by
altering
permeability
intestinal
cells.
effect
compromised
on
health
through
altered
activity
discussed.
Nutrients,
Год журнала:
2024,
Номер
16(7), С. 1054 - 1054
Опубликована: Апрель 4, 2024
The
microbiota-gut-brain
(MGB)
axis
is
a
complex
communication
network
linking
the
gut,
microbiota,
and
brain,
influencing
various
aspects
of
health
disease.
Dysbiosis,
disturbance
in
gut
microbiome
equilibrium,
can
significantly
impact
MGB
axis,
leading
to
alterations
microbial
composition
function.
Emerging
evidence
highlights
connection
between
microbiota
neurological
psychiatric
disorders,
including
depression.
This
review
explores
potential
psychobiotics
managing
depressive
emphasizing
their
role
restoring
balance
axis.
Psychobiotics
exhibit
positive
effects
on
intestinal
barrier,
immune
response,
cortisol
levels,
hypothalamic-pituitary-adrenal
(HPA)
Studies
suggest
that
probiotics
may
serve
as
an
adjunct
therapy
for
depression,
especially
treatment-resistant
cases.
discusses
key
findings
from
studies
interventions,
gut-brain
mental
health.
increasing
acceptance
expanded
concept
underscores
importance
microorganisms
well-being.
As
our
understanding
microbiome's
disease
grows,
emerge
promising
agents
addressing
issues,
providing
new
avenues
therapeutic
interventions
disorders.
Biomedicines,
Год журнала:
2024,
Номер
12(9), С. 1994 - 1994
Опубликована: Сен. 2, 2024
Depression
affects
several
aspects
of
life,
including
socioeconomic
status,
relationships,
behavior,
emotions,
and
overall
health.
The
etiology
depression
is
complex
influenced
by
various
factors,
with
obesity
emerging
as
a
significant
contributor.
This
narrative
review
aims
to
investigate
the
factors
associated
development
depression,
particular
focus
on
role
obesity.
literature
search
was
conducted
PubMed,
Embase,
PsycINFO
from
May
July
2024.
highlights
impact
environmental
conditions;
lifestyle
choices,
physical
activity
dietary
habits;
stress;
traumatic
experiences;
neurotransmitter
imbalances;
medical
psychological
hormone
fluctuations;
epigenetic
depression.
A
key
emphasis
placed
inflammatory
processes
linked
obesity,
which
may
drive
bidirectional
relationship
between
findings
suggest
that
an
increased
risk
potentially
due
chronic
inflammation,
neurochemical
dysregulation,
emotional
social
challenges
related
weight
stigma
management.
Understanding
these
interconnected
important
for
developing
targeted
interventions
address
both
leading
improved
quality
life
those
affected.
Chronic
inflammation
is
increasingly
recognized
as
a
critical
factor
in
female
reproductive
health;
influencing
natural
conception
and
the
outcomes
of
assisted
technologies
such
vitro
fertilization
(IVF).
An
essential
component
innate
immunity,
NLR
family
pyrin
domain-containing
3
(NLRP3)
inflammasome
one
major
mediators
inflammatory
responses,
its
activation
closely
linked
to
oxidative
stress.
This
interaction
contributes
decline
oocyte
quality,
reduced
potential,
impaired
embryo
development.
In
ovarian
milieu,
stress
NLRP3
interact
intricately,
their
combined
effects
on
competence
are
significant.
The
aims
this
review
examine
these
molecular
mechanisms
explore
therapeutic
strategies
targeting
activity,
with
goal
enhancing
fertility
improving
clinical
health.
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
16
Опубликована: Март 18, 2025
Polycystic
ovary
syndrome
(PCOS)
is
a
common
endocrine
and
metabolic
disorder
affecting
reproductive-age
women,
characterized
primarily
by
hyperandrogenism,
ovulatory
dysfunction,
abnormalities.
In
recent
years,
the
gut
microbiota
has
garnered
widespread
attention
for
its
potential
role
as
key
regulator
of
host
metabolism
in
pathogenesis
PCOS.
Studies
have
shown
that
PCOS
patients
exhibit
dysbiosis
their
microbiota,
reduced
microbial
diversity,
an
imbalance
ratio
Firmicutes
to
Bacteroidetes,
changes
abundance
specific
taxa,
abnormal
levels
products.
These
alterations
may
exacerbate
dysfunction
through
multiple
mechanisms,
including
influencing
energy
metabolism,
disrupting
lipid
bile
acid
inducing
chronic
inflammation.
Addressing
modulation
patients'
microbiomes-such
use
of,
prebiotics,
fecal
transplantation,
optimizing
diet
lifestyle-may
offer
strategies
improving
abnormalities
alleviating
clinical
symptoms
Additionally,
microbiome
promises
marker,
aiding
precise
diagnosis
personalization
Although
our
current
understanding
how
influences
still
limited,
research
needed
explore
causal
relationships
mechanisms
involved,
providing
more
reliable
theoretical
basis
clinical.
This
review
aims
summarize
progress
on
relationship
between
PCOS,
suggest
future
directions
promote
development
prevention
treatment
Cancers,
Год журнала:
2025,
Номер
17(7), С. 1198 - 1198
Опубликована: Март 31, 2025
(1)
Background:
Exploring
real-world
data
(RWD)
regarding
immune-related
adverse
events
(irAEs)
is
crucial
to
better
understand
the
efficacy
and
safety
of
immunotherapy
in
cancer
patient
populations
excluded
from
clinical
trials.
An
analysis
was
conducted
evaluate
presumptive
predictive
causality
between
endocrine
irAEs
immune
check-point
inhibitors
(ICIs)
metastatic
non-small-cell
lung
(mNSCLC)
patients
treated
daily
practice
Romania.
(2)
Methods:
This
a
retrospective
cohort
study
mNSCLC
with
ICIs
tertiary
level
hospital
Romania
for
period
almost
seven
years,
November
2017
till
July
2024.
Endocrine
were
well
defined
as
any
occurring
autoimmune
endocrinopathy
during
related
immunotherapy.
The
endocrinologist
(M.C.C.O)
diagnosed,
treated,
followed
these
multidisciplinary
approach.
We
investigated
multiple
medical
variables
assess
their
impact
on
ICI
effectiveness.
Descriptive
statistical
analyses
performed.
(3)
Results:
Of
487
ICIs,
we
identified
215
who
evaluated
co-medications
therapy.
Forty-seven
(21.8%)
experienced
irAEs,
thyroiditis
being
most
frequent
prevalent
60%
cases.
statistically
significant,
correlated
(p
=
0.002)
survival
analysis.
Steroids
proton-pump
used
co-medication
had
negative
response
(4)
Conclusions:
might
be
considered
biomarkers
successful
patients.
Co-medication
major
influence
effectiveness
cutting-edge
therapies.
RWD
plays
an
important
role
oncology
whenever
trial
evidence
not
available
guide
decision.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 14, 2025
Prostate
cancer
(PCa)
is
the
second
most
common
malignant
tumor
in
men
worldwide,
and
its
metastatic
heterogeneous
nature
makes
it
significantly
more
difficult
to
treat.
Recent
studies
have
revealed
critical
role
of
microbiota
PCa
occurrence,
progression,
treatment.
Accumulating
evidence
from
16S
rRNA
metagenomic
sequencing
suggests
presence
specific
prostate
tissues
macrogenomics
techniques:
cancerous
are
enriched
with
pro-inflammatory
genera
(e.g.,
Fusobacterium
,
Propionibacterium
acnes
),
whereas
commensal
bacteria
Pseudomonas
)
paracancerous
tissues.
The
drive
progression
through
activation
NF-κB/STAT3
pathway
induce
chronic
inflammation,
modulation
immune
microenvironment
Treg/Th17
imbalance
M2-type
macrophage
polarization),
metabolite
LPS,
short-chain
fatty
acids)–mediated
hormonal
epigenetic
regulation.
In
terms
clinical
translation,
urinary
characterization
combined
metabolomics
analysis
may
enhance
diagnostic
specificity,
while
gut
flora
probiotic
interventions
or
fecal
transplants)
improve
resistance
androgen
deprivation
therapy.
Current
challenges
include
accuracy
low-biomass
samples,
limitations
causal
mechanism
validation
models,
large
cohort
heterogeneity.
future,
will
be
necessary
integrate
multi-omics
technologies
explore
bidirectional
regulation
“gut-prostate
axis”
develop
personalized
therapeutic
strategies
targeting
microorganisms.
this
paper,
we
systematically
review
interactions
between
their
potentials
provide
a
theoretical
basis
for
precision
diagnosis
Microorganisms,
Год журнала:
2025,
Номер
13(4), С. 948 - 948
Опубликована: Апрель 20, 2025
Trillions
of
microorganisms
play
a
pivotal
role
in
maintaining
health
and
preventing
disease
humans.
Their
presence
influences
daily
life,
habits,
energy
levels,
pathologies.
The
present
narrative
review
synthesized
recent
studies
microbial
diversity
across
organ
systems.
composition
the
microbiota
regulates
intestinal
barrier,
modulates
immune
response,
metabolism,
produces
essential
compounds
such
as
short-chain
fatty
acids
neurotransmitters.
Dysbiosis
is
associated
with
numerous
pathologies,
including
metabolic,
autoimmune,
neurodegenerative,
cardiovascular
diseases.
key
to
physiological
balance
reducing
risk.
Therapeutic
interventions,
probiotics,
prebiotics,
postbiotics,
microbiome
transplantation,
offer
promising
perspectives
restoring
homeostasis
chronic
Lipids in Health and Disease,
Год журнала:
2024,
Номер
23(1)
Опубликована: Фев. 29, 2024
Abstract
Background
Extensive
evidence
demonstrates
correlations
among
gut
microbiota,
lipid
metabolism
and
cognitive
function.
However,
there
is
still
a
lack
of
researches
in
the
field
late-life
depression
(LLD).
This
research
targeted
at
investigating
relationship
indexes,
such
as
total
free
fatty
acids
(FFAs),
functions
LLD.
Methods
Twenty-nine
LLD
patients
from
Cognitive
Outcome
Cohort
Study
Depression
Elderly
were
included.
estimated
through
Chinese
version
Montreal
Assessment
(MoCA).
Blood
samples
collected
to
evaluate
serum
parameters.
Fecal
evaluated
for
microbiota
determination
via
16S
rRNA
sequencing.
Spearman
correlation,
linear
regression
mediation
analysis
utilized
explore
function
patients.
Results
correlation
revealed
significant
Akkermansia
abundance,
Free
Fatty
Acids
(FFAs)
MoCA
scores
(
P
<
0.05).
Multiple
indicated
FFAs
significantly
predicted
Mediation
demonstrated
that
between
decreased
relative
abundance
decline
was
partially
mediated
by
(Bootstrap
95%CI:
0.023–0.557),
accounting
43.0%
effect.
Conclusion
These
findings
suggested
,
well
FFAs.
Total
functions.
results
contributed
understanding
microbial-host
axis
